Triiodothyronines in Health and Disease

1. Description, History, and Calorigenic Activity of Iodothyronines.- 2. Transport of Iodothyronines.- A. Thyroxine-Binding Globulin.- B. Thyroxine-Binding Prealbumin.- C. Free Thyroid Hormones.- 3. Triiodothyronine: Molecular Structure and Biologic Function.- A. Introduction.- B. Stereochemistry and Molecular Conformation.- C. Conformational Analysis.- D. Role of Iodine in Conformation and Activity.- E. Protein Binding and Biologic Activity.- F. Summary.- 4. Concentration of Triiodothyronines (T3 and Reverse T3) in Serum and Other Body Fluids.- A. Methods of Measurements.- B. Serum T3 Concentration in Health and Disease.- C. Urinary Excretion of T3s.- 5. Kinetics of Peripheral Metabolism and Production Rates of T3s.- A. Methods of Measurement and Normal Values.- B. Alterations in Thyroid Diseases.- C. Alterations in Nonthyroid Diseases and Low-T3 Syndrome.- 6. Sources of T3s: Thyroidal Secretion Versus Extrathyroidal Metabolism of T4.- 7. Nature of the Processes of and Factors Influencing Production of T3s fromT4.- A. Outer-Ring Monodeiodination of T4 to T3.- B. Inner-Ring Monodeiodination of T4 to Reverse T3.- 8. Routes of T3s Metabolism.- A. In Vivo Studies.- B. In Vitro Studies.- 9. Biologic Effects of lodothyronines.- A. Mechanism of Action.- B. Some Other Interesting Effects of Thyroid Hormones.- C. Relative Potency in Various Effects.- References.