Conjugation—Deconjugation Reactions in Drug Metabolism and Toxicity
Springer Berlin (Verlag)
978-3-642-78431-6 (ISBN)
Section I: Transferases and Hydrolases Involved in Phase II Conjugation-Deconjugation Reactions, Genetic Polymorphism and Regulation of Expression.- 1 The Uridine Diphosphate Glueuronosyltransferase Multigene Family: Function and Regulation With 7 Figures.- 2 Sulfotransferase Enzymes With 6 Figures.- 3 Regulation of Expression of Rat Liver Glutathione S-Transferases: Xenobiotic and Antioxidant Induction of the Ya Subunit Gene With 6 Figures.- 4 Human N-Acetyltransferases With 3 Figures.- 5 Genetic Regulation of the Subcellular Localization and Expression of Glucuronidase With 5 Figures.- 6 Microsomal Amidases and Carboxylesterases With 5 Figures.- 7 O-, N, and S-Methyltransferases With 2 Figures.- Section II: Regulation of Phase II Conjugation: Deconjugation Reactions in Intact Cells and Tissues.- 8 Cofactor Supply as a Rate-Limiting Determinant of Hepatic Conjugation Reactions With 5 Figures.- 9 Regulation of Drug Conjugate Production by Futile Cycling in Intact Cells With 4 Figures.- 10 Pharmacokinetic Modeling of Drug Conjugates With 22 Figures.- 11 Regulation of Drug Conjugate Processing by Hepatocellular Transport Systems With 1 Figure.- Section III: Pharmacology and Toxicology of Drug Conjugates.- 12 Biologically Active Conjugates of Drugs and Toxic Chemicals With 5 Figures.- 13 Acyl Glucuronides as Chemically Reactive Intermediates With 10 Figures.- 14 Roles of Uridine Diphosphate Glucuronosyltransferases in Chemical Carcinogenesis With 9 Figures.- 15 Sulfonation in Chemical Carcinogenesis With 11 Figures.- 16 Glutathione Conjugate-Mediated Toxicities With 8 Figures.- 17 Challenges and Directions for Future Research.
Erscheint lt. Verlag | 22.11.2011 |
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Reihe/Serie | Handbook of Experimental Pharmacology |
Co-Autor | K.W. Bock, B. Burchell, M. Chiba, D.J. Clarke, C.R. Creveling, C. Fenselau, Frederick C. Kauffman, G.Y. Kwei, S.S. Lau, W. Lilienblum, A.Y.H. Lu, J.A. Miller, T.J. Monks, E.K. Novak, D. Otterness, K.S. Pang, C.B. Pickett, L.A. Reinke, T.H. Rushmore, Y.-J. Surh, R.T. Swank, D.R. Thakker, R.G. Thurman, K.P. Vatsis, M. Vore, C.Y. Wang, W.W. Weber, R. Weinshilboum, J. Zaleski, L. Zhen |
Zusatzinfo | XXIV, 530 p. |
Verlagsort | Berlin |
Sprache | englisch |
Maße | 155 x 235 mm |
Gewicht | 837 g |
Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie |
Medizin / Pharmazie ► Pharmazie | |
Schlagworte | acyl-linked conjugates • conjugate • Drug conjugates • enzymes • Hydrolases • Konjugation • Metabolism • Regulation • Stoffwechsel • Stoffwechsel / Metabolismus • Transferasen • Transferases • Transport |
ISBN-10 | 3-642-78431-3 / 3642784313 |
ISBN-13 | 978-3-642-78431-6 / 9783642784316 |
Zustand | Neuware |
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