Clinical Pharmacology in Psychiatry

Molecular Modeling of Neurotransmitter Receptors.- Structure-Function Analysis of the Three ?-Adrenergic Catecholamine Receptors.- Serotonin Receptor Subtypes.- Developmental Regulation of 5-HT2 and 5-HT1c Receptor Gene Expression in Rat Brain.- Relevance of 5-HT Autoreceptors for Psychotropic Drug Action.- Brain Serotonin Subsystem Complexity and Receptor Heterogeneity: Therapeutic Potential of Selective Serotonin Agonists and Antagonists.- Serotonin Receptors and Antipsychotic Drug Action.- The Third Dopamine Receptor (D3): New Perspectives in Therapeutics.- PET Examination of Central D2 Dopamine Receptor Occupancy in Relation to Extrapyramidal Syndromes in Patients Being Treated with Neuroleptic Drugs.- Dopaminergic and Serotonergic Aspects of Acute Extrapyramidal Syndromes.- Methods to Facilitate Early Exploratory Testing of Novel Psychopharmacologic Agents in Humans.- Neuroleptics and Diagnostic Heterogeneity in Relation to Drug Evaluation.- Residual and Negative Symptoms in Treatment with Neuroleptics.- Clinical Dosing of Neuroleptics.- Diagnostic Heterogeneity in Relation to Drug Evaluation: Antidepressants.- Dose-Effect Relationships for Tricyclic Antidepressants: The Basis for Rational Clinical Testing of New Antidepressants.- Dose-Effect and Concentration-Effect Relationships with New Antidepressants.- Therapeutic Potentials of Recently Introduced Antidepressants.- Role of Genetic Polymorphism in Psychopharmacology - An Update.- Psychotropic Drug Metabolism and Clinical Monitoring.- Disposition of the Neuroleptics Perphenazine, Zuclopenthixol, and Haloperidol Cosegregates with Polymorphic Debrisoquine Hydroxylation.- Phenotypes for Psychotropic Drug Metabolism in the Elderly.- Analysis of 935 Haloperidol Concentration Measurements Obtained During RoutineDrug Monitoring of 134 Patients.- Power Analysis for Correlation of Plasma Level and Clinical Data.