Cytotoxic Effector Mechanisms

Granule-Mediated Cytolysis of Target Cells.- Structure and Function of Perforin.- Structure and Function of C8 in the Membrane Attack Sequence of Complement.- Granzymes: a Family of Serine Proteases in Granules of Cytolytic T Lymphocytes.- The Molecular Mechanism of Complement C9 Insertion and Polymerisation in Biological Membranes.- The Isolation and Characterization of Two Cytotoxic T-Lymphocyte-Specific Serine Protease Genes.- A Serine Protease-Encoding Gene That Marks Activated Cytotoxic T Cells In Vivo and In Vitro.- Structure and Function of the Family of Proteoglycans That Reside in the Secretory Granules of Natural Killer Cells and Other Effector Cells of the Immune Response.- The Homologous Species Restriction of the Complement Attack: Structure and Function of the C8 Binding Protein.