Clinical Pharmacology in Psychiatry

Molecular Pharmacology in Drug Development.- Molecular Modeling in Drug Design.- Synthesis of New Peptides Based on Models of Receptor-Bound Conformation.- Molecular Approach to the Mechanism of Action of Antidepressant Drugs.- Anxiolytics.- Modulation of the Benzodiazepine-GABA Receptor Chloride Ionophore Complex by Multiple Allosteric Sites: Evidence for a Barbiturate "Receptor".- ?-Carbolines: New Insights into the Clinical Pharmacology of Benzodiazepine Receptor Ligands.- Pharmacodynamic Approaches to Benzodiazepine Action in Man.- Correlating Pharmacokinetics and Pharmacodynamics of Benzodiazepines: Problems and Assumptions.- Benzodiazepine-Serotonin Interactions in Man.- Comparative Pharmacodynamics of Benzodiazepines.- Abuse Liability of Triazolam: Experimental Measurements in Animals and Humans.- Clinical Studies of "Specific" Anxiolytics as Therapeutic Agents.- Antidepressants.- Regulation of Beta Adrenergic and Serotonin-S2 Receptors in Brain by Electroconvulsive Shock and Serotonin.- ?2-Adrenoceptor Antagonists as Antidepressants: The Search for Selectivity.- GABA Synapses, Depression, and Antidepressant Drugs.- Antidepressant Monoamine Oxidase Inhibitors Enhance Serotonin but not Norepinephrine Neurotransmission.- Selective Amine Oxidase Inhibitors: Basic to Clinical Studies and Back.- Therapeutic Effect of Selective 5HT Reuptake Inhibitors in Comparison with Tricyclic Antidepressants.- Accidental Antidepressants: Search for Specific Action.- Antidepressants and EEG Sleep: Search for Specificity.- Possible Teratogenic Effects of Imipramine in the Rat.- Pharmacological Specificity Is Not the Same as Clinical Selectivity.- Pharmacokinetic Considerations Relevant to the Pharmacodynamics of Antidepressants.- Receptor Assay Based on 3H-ImipramineBinding.- Neuroleptics.- Pharmacological Validation of the Two-Dopamine-Receptor Hypothesis.- Differential Regulation of Dopamine-D2 and Serotonin-S2 Receptors by Chronic Treatment with the Serotonin-S2 Antagonists, Ritanserin and Setoperone.- Chronic Neuroleptic Effects on Dopamine Neuron Activity: A Model for Predicting Therapeutic Efficacy and Side Effects?.- Effect of Selective D1 and D2 Dopamine Receptor Antagonists and Agonists in Cebus Monkeys: Implications for Acute and Tardive Dyskinesias. A Preliminary Report.- Neuroleptic-lnduced Parkinsonism Increases with Repeated Treatment in Monkeys.- Biochemical Alterations Produced by Neuroleptics in Man: Studies of Plasma Homo vanillic Acid in Schizophrenic Patients.- Effect of Neuroleptics on the Schizophrenic Syndrome.- Pharmacokinetic and Pharmacodynamic Factors Causing Variability in Response to Neuroleptic Drugs.- List of Participants.