Aminoglycoside Antibiotics

1 The Naturally Occurring Aminoglycoside Antibiotics.- A. Introduction.- B. Aminoglycoses and Noncyclitol Aminoglycosides.- C. Aminocyclitol Aminoglycosides Containing Streptamine, 2-Deoxystreptamine, or Their Derivatives.- D. Aminoglycosides with Cyclitol Aglycones Other than Streptamine or 2-Deoxystreptamine.- References.- 2 Total Synthesis and Chemical Modification of the Aminoglycoside Antibiotics.- A. Introduction.- B. Several Reactions and Methods Generally Useful for the Synthesis of Aminoglycoside Antibiotics.- C. Total Synthesis and Modification of Aminoglycoside Antibiotics.- References.- 3 Biosynthesis and Mutasynthesis of Aminoglycoside Antibiotics.- A. Introduction.- B. Biosynthesis of Major Aminoglycosides.- C. Mutational Biosynthesis (Mutasynthesis).- D. Conclusion.- References.- 4 Antibacterial Activity of Aminoglycoside Antibiotics.- A. Introduction.- B. Drug Resistance Plasmids.- C. Resistance Patterns of Bacteria.- D. Bacterial Strains Resistant to Aminoglycoside Antibiotics.- E. Conclusion.- References.- 5 Mechanism of Action of Aminoglycoside Antibiotics.- A. The Effects on Bacterial Cells and Their Components.- B. Effects on Mammalian or Eukaryotic Cells and Their Components.- C. Peptide Antibiotics Showing Similar Mechanisms of Inhibition of Ribosomal Functions.- D. Discussion.- E. Summary.- References.- 6 Mechanisms of Resistance to Aminoglycoside Antibiotics.- A. Introduction.- B. Biochemical Mechanisms of Resistance.- C. Derivatives Active Against Resistant Strains.- D. Conclusion.- References.- 7 Toxicology and Pharmacology of Aminoglycoside Antibiotics.- A. Introduction.- B. Nephrotoxicity of Aminoglycosides.- C. Ototoxicity of Aminoglycosides.- D. Acute Lethal Toxicity of Aminoglycosides.- E. Correlation Between Chemical Structure and LD50 Values of Aminoglycosides.- F. General Pharmacology of Aminoglycosides.- G. Pharmacokinetics.- References.