Kinetics of Drug Action

General Introduction.- 1 Physicochemical Fundamentals and Thermodynamics of the Membrane Transport of Drugs..- I. Introduction.- II. Systems and Membrane Types.- III. Classification of Membrane Transport.- IV. Kinetics and Thermodynamics of Membrane Transport.- Appendix. Glossary of Symbols.- References.- 2 Pharmacokinetics. Kinetic Aspects of Absorption, Distribution, and Elimination of Drugs..- I. Introduction.- II. Pharmacokinetic Models.- III. Models for Single-Dose Administration.- IV. Multiple Dose Administration.- V. Conclusion.- References.- 3 Pharmacokinetics of Biotransformation..- I. Introduction.- II. Conclusion.- References.- 4 General Theory of Drug-Receptor Interactions. Drug-Receptor Interaction Models. Calculation of Drug Parameters..- I. Introduction.- II. Drugs, Receptors and Effects.- III. Agonistic Interaction.- IV. Competitive Interaction.- V. Metactoid Interaction.- VI. Metaffinoid Interaction.- VII. Functional Interaction.- VIII. Plural Affinities.- IX. Numerical Expressions of Intrinsic Activity and Affinity.- References.- 5 A Critical Survey of Receptor Theories of Drug Action..- I. Introduction.- II. The Mathematics of Drug-Receptor Interactions.- III. Occupation Theories of Drug Action.- IV. The Rate Theory of Drug Action.- V. A General Discussion of the Various Receptor Models.- VI. A General Discussion of the Possible Uses of Receptor Models.- Appendix. Glossary of Symbols.- References.- 6 Drug-Receptor Inactivation: A New Kinetic Model..- I. Introduction.- II. Energetics of Receptor Activity.- III. Models in Which Trigger Energy is Generated.- IV. Models Involving Irreversible Alterations of Agonist or Receptor.- V. A Receptor Inactivation Theory.- VI. Stationary State Behavior with Single Agonists.- VII. Transient State Behavior with Single Agonists.- VIII. Stationary State Behavior with Agonist-Antagonist Mixtures.- IX. Transient State Behavior with Agonist-Antagonist Mixtures.- X. General Discussion.- XI. Summary.- Addendum A.- Addendum B.- Appendices: Glossary-Generalized Rate Equations for the Receptor Inactivation Model-"On" Effect-"Off" Effect-Analysis of Oscillations-Receptor Interactions with Agonist-Antagonist Mixtures.- References.- 7 Kinetics of Drug-Receptor Interaction..- I. Introduction.- II. Diffusion of Drug to Receptor.- III. Intermolecular Forces in Drug-Receptor Reactions.- IV. Kinetics of Drug-Receptor Association and Dissociation.- V. Possibilities for Measuring Rate Constants in Drug-Receptor Interaction.- VI. Conformational Changes in the Drug-Receptor Complex.- VII. Kinetics of Drug-Receptor Interaction, Including Conformational Changes.- VIII. Some Other Notions in Molecular Pharmacology.- IX. Activation Parameters.- References.- Conclusion.- Author Index.