DNA and RNA Cleavers and Chemotherapy of Cancer and Viral Diseases

Preface xi.- List of Contributors xiii.- List of Participants xvii.- DNA cleavage by enediyne molecules.- Enediynes as Probes of Nucleic Acid Structure.- The Intrinsic Flexibility and Drug-Induced Bending of Calicheamicin DNA Targets.- Recent Biophysical and Biological Studies on the Mechanism of Action of Calicheamicin.- Kedarcidin and Maduropeptin, Two Novel Chromoproteins with Potent Antitumor Activities.- Dynemicin A, a Novel Enediyne DNA Cutter.- Bleomycin: the paradigm of DNA cleavers based on metal complexes.- Polynucleotide Cleavage and the Expression of Antitumor Activity by Bleomycin.- Bleomycin Reaction Pathways: Kinetic Approaches.- Selected Generation and Cleavage of C4’-Modified Oligonucleotides.- Site-specific DNA cleavage.- Site Specific Oxidative Scission of Nucleic Acids and Proteins.- Sequence Selective DNA Cleavage by PNA-NTA Conjugates.- The Synthesis and DNA/RNA Hybridization Properties of DNG, a Putative Antisense Agent with an Attractive Polycationic Guanidinium Backbone.- Design of Photoactivatable DNA-Cleaving Amino Acids with High Sequence Selectivity.- Rational Design of a New Class of DNA Cleaver Based on Prediction of Minor Groove Binding Interactions and NMR Structural Studies.- Binary Systems of Oligonucleotide Conjugates for Sequence Specific Energy-Transfer Sensitized Photomodification of Nucleic Acids.- Mechanism of oxidative DNA cleavage.- Targeted Oxidative DNA Cleavage Mediated by Oligonucleotide-Cationic Metalloporphyrin Conjugates.- Pulse Radiolysis and Laser Photolysis Studies on Nucleotide Radicals. The Protonation State of the Radicals.- Redox Regulation of the Human Immunodeficiency Virus Type 1 (HIV-1).- RNA cleavage by RNase H.- Ribonuclease H: from Enzymes to Antisense Effects of Oligonucleotides.- Hydrolysis of RNA byribozymes and metal complexes.- Structure, Activity and Application of Chemically Modified Hammerhead Ribozymes.- The Hairpin Ribozyme.- Sequence-Specific Cleavage of RNA Using Lanthanide Complexes Linked to Oligonucleotides.- Synergism of Two Metal Ions for the Hydrolysis of DNA and RNA.- Texaphyrin-Based Nuclease Analogues. Rationally Designed Approaches to the Catalytic Cleavage of RNA and DNA Targets.- Ribozyme Mimics for Catalytic Antisense Strategies.