Plasmids

Introductory Lectures.- Biological Significance of Drug Resistance Plasmids.- Antibiotic Policy-an All-Nation Computer-assisted Model.- Geographic Differences in Antibiotic Susceptibility Patterns: Staphylococci.- I. Environmental Consequences of Plasmids.- Resistant E.coli of Farm Origin and their possible Danger to Man. (Opening Lecture).- R Plasmids in fish Pathogens.- R Plasmids which Reduce Nitrofuran Sensitivity of Their Host Bacteria; their Role in the Selection of R-Plasmids-Carrying Bacteria.- Drug Resistance in Staphylococcus aureus Strains Isolated from Raw Milk.- Frequency and Some Properties of Methicillin-Resistant Strains of Staphylococcus aureus Isolated from Clinical Sources.- Survey of Drug Resistance in Staphylococcus aureus.- Colonization of the Intestine in New-born Children by R-Plasmid-Carrying Coliforms.- II. Genetics of Plasmids.- Plasmid-Chromosome Interactions in Pseudomonas aeruginosa (Opening Lecture).- Intrinsic Resistance to Aminoglycosides in Pseudomonas aeruginosa.- Drug-Resistance Plasmids in Pseudomonas aeruginosa.- Plasmid-Determined Resistance to Erythromycin and Lincomycin in Streptococcus pyogenes.- Genetic Characterization of Transferable Plasmids Presumed to be Unloaded.- A Physical Analysis of Mating in Escherichia coli.- Studies with ? Transducing Phages Bearing Antibiotic Resistance Genes from the Plasmid R100.- ? Tra Transducing Phages.- Physical Mapping and Molecular Relationship of the R Factors RP1, RP4 and RP8.- Transposition of the Ampicillin Resistance Gene from the RP4 Factor to the Bacteriophage P1 and to the Escherichia coli Fertility Factor.- Identification and Characterization of a New Resistance Transfer Factor Isolated from Escherichia coli.- Transfer of Gentamicin-Tobramycin Resistance and of Hemolytic Toxin Production from Lysogenic, Hospital Strains of Pseudomonas aeruginosa in Mixed Cultures and by Transduction.- Plasmid-Chromosome Interaction in Hfr Strains.- Control of the Replication of an R Plasmid Rtsl.- Hybrid R Plasmids between Temperature-Sensitive Rtsl and a Transfer-Deficient Derivative of NR1: Integrative Suppression of the Temperature-Sensitive Replication of Rtsl.- Plasmids in Streptomycetes.- Genetical and Biochemical Aspects of Replication of the Bacteriocinogenic Plasmid Clo DF 13.- In vivo and in vitro Synthesized Gene Products of the Bacteriocinogenic Plasmid Clo DF 13.- The Action of Colicins in other Cells than Rod-Shaped Enteric Bacteria.- III. Molecular Biology of Plasmids.- A) Replication of DNA.- Dissociation and Replication of Segments of a Composite R Plasmid in Proteus mirabilis and Escherichia coli.- Replication of R Plasmid DNA in Proteus mirabilis.- A Technique for the Analysis of Non-Replicating and Replicating Forms of R6K Plasmid DNA in Escherichia coli: Relationship to the Folded Chromosome.- Various Types of Mutant R Plasmids that Specify Hypersynthesis of ? -Lactamase.- Recombination Sequences and the Amplification of the Tetracycline-Resistance Determinant in Plasmid pM?l of Streptococcus faecalis.- Generation of Small Ampicillin-Resistant Plasmids (Rsc) and their Mode of Replication.- Relaxation Complexes Affecting Plasmids in Staphylococcus aureus Encoding Streptomycin and Chloramphenicol Resistance.- In vitro Translation of R-factor DNA.- B) Mechanism of Resistance to Antibiotics.- Oxacillin-Hydrolyzing Penicillinase of Aeromonas hydrophyla.- Anion Effect on Oxacillin-Hydrolyzing Penicillinase of an R Plasmid.- Adenosine 3?, 5?-Cyclic Monophosphate-Dependent and Independent Production of Chloramphenicol Acetyltransferase in Escherichia coli Carrying R plasmids.- ?-Lactamase-Directed Barrier of Escherichia coli Carrying R Plasmids for Penicillins and Cephalosporins.- Phenotypic Expression of Methicillin Resistance in Staphylococcus aureus.- Resistance of Haemophilus to Aminoglycoside Antibiotics.- Mechanism of R-Mediated Streptomycin Resistance in Pseudomonas aeruginosa.- IV. Plasmid Engineering.- Biohazard Assessment of Re