The HLA System in Clinical Transplantation

The Life and Times of the Human Major Histocompatibility Complex.- Origins of Mhc Diversity.- Genetics, Chemistry and Expression.- MHC Genes.- Class I and Class II HLA Proteins and Genes: An Overview of Structure, Polymorphism, and Expression.- Assembly and Intracellular Transport of MHC Molecules.- Regulation and Deregulation of HLA Class II Genes.- Minor Transplantation Antigens.- Biological Function of MHC Molecules.- Biological Function of HLA Molecules.- MHC Molecules in Thymic Development and Selection of the T Cell Repertoire.- The Molecular Mechanisms of HLA Associated Autoimmunity.- The Capacity of Class I MHC Molecules to Function as Signal Transduction Elements.- The Major Histocompatibility Complex and Cell Physiology.- MHC Control of Growth and Metastatic Properties of Tumor Cells.- Allorecognition of HLA Molecules.- HLA Molecules in Allorecognition: T Cell Recognition and Typing Methods.- B Cell Recognition and HLA Typing: Current Methods and Future Possibilities. Role of Alloantibodies and Monoclonal Antibodies as Reagents.- HLA Antibodies, Non-HLA Antibodies, and Crossmatch Methods.- Transplantation of the Alloimmunized Patient.- HLA-Matching.- HLA Matching in Clinical Organ Transplantation.- Transplantation Tolerance and Noninherited Maternal HLA Antigens.- What To Do with the Immunized Patient. How to Avoid Humoral Immunization.- Immunosuppression.- Immunosuppressive Therapy.- Selective Depletion of Alloreactive Cells in Transplantation.- Immunological Considerations on the Use of Monoclonal Antibodies for In Vitro and In Vivo Modification of Alloimmunity.- Anti-idiotypic Antibodies in the HLA System.- Rejection.- Cellular and Molecular Mechanism of Rejection and Role of Viral Infection.- Fine-Needle Aspiration Biopsy in Rejection Diagnosis.- Bone Marrow Transplantation.- Bone Marrow Transplantation Using Related Donors.- Marrow Transplantation from Unrelated Donors.- Purging of Bone Marrow.- Xenografting.- Xenografting: Is It Feasible?.- Malignancy after Transplantation.- Tumors in Transplanted Patients.- Addendum.- Nomenclature for the Major Histocompatibility Complexes of Different Species: A Proposal.- Revised Nomenclature of Mouse H-2 Genes.