The Genetic Basis of Human Cancer

Part 1 Basic concepts in genetics: genetics, biochemistry and the molecular basis of variant human phenotypes; the nature and mechanisms of human gene mutation; the Human Genome Project; genetic imprinting in cancer. Part 2 Controls on cell growth: control of the cell cycle; apoptosis and cancer; oncogenes; tumour suppressor genes. Part 3A Inherited mutations - defects in DNA repair: xeroderma pigmentosa; ataxia telangiectasia; Bloom's syndrome; Fanconi anaemia; hereditary non-polyposis colorectal cancer; Werner syndrome. Part 3B defects in growing controlling genes: retinoblastoma; Li-Fraumenni syndrome; Wilms tumour; peripheral neurofibromatosis; central neurofibromatosis; renal carcinoma; multiple endocrine neoplasia; malignant melanoma; breast cancer; colorectal tumours. Part 4 Somatic mutations: chromosome translocations in leukemias and lymphomas; chromosome rearrangements human in solid tumours; gene amplification in human cancers - biological and clinical significance; pancreatic cancer; ovarian cancer; endometrial cancer; cervical cancer; bladder cancer; stomach cancer; prostate cancer; brain tumours; lung cancer; skin cancer; hepatocellular carcinoma; genetic testing for cancer.