Hepatic Encephalopathy (eBook)

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2012 | 2012
XIV, 250 Seiten
Humana Press (Verlag)
978-1-61779-836-8 (ISBN)

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Because of the increasing burden of hepatitis C and fatty liver disease, there is an explosion in the prevalence of chronic liver failure and hence its complications. The onset of Hepatic Encephalopathy (HE) in these patients has a significant impact on the quality of life, morbidity and mortality. Unfortunately, the approach observed by most clinicians to this complex disorder is minimalistic.

This book provides a comprehensive review on pathophysiology and clinically important aspects in HE. Topics in basic physiology, nitrogen metabolism, new insights into pathogenesis and brain edema are covered in great detail. The authors have made a special effort by simplifying the complex aspects of pathogenesis and diagnosis so that it can be easily understood and applied clinically. This volume also focuses on recent developments regarding diagnoses of subtle forms of HE, also known as minimal or covert HE as well as on new treatments. Hepatic Encephalopathy will be of great value to gastroenterologists, hepatologists, pathologists, medical residents, fellows, internists and general practitioners who treat patients with hepatic encephalopathy.


Because of the increasing burden of hepatitis C and fatty liver disease, there is an explosion in the prevalence of chronic liver failure and hence its complications. The onset of Hepatic Encephalopathy (HE) in these patients has a significant impact on the quality of life, morbidity and mortality. Unfortunately, the approach observed by most clinicians to this complex disorder is minimalistic.This book provides a comprehensive review on pathophysiology and clinically important aspects in HE. Topics in basic physiology, nitrogen metabolism, new insights into pathogenesis and brain edema are covered in great detail. The authors have made a special effort by simplifying the complex aspects of pathogenesis and diagnosis so that it can be easily understood and applied clinically. This volume also focuses on recent developments regarding diagnoses of subtle forms of HE, also known as minimal or covert HE as well as on new treatments. Hepatic Encephalopathy will be of great value to gastroenterologists, hepatologists, pathologists, medical residents, fellows, internists and general practitioners who treat patients with hepatic encephalopathy.

Ch. 1 Introduction, Nomenclature and Classification of Hepatic EncephalopathyKevin D. Mullen Ravi K. Prakash  Section A: Pathogenesis  Ch. 2: Role of Ammonia in the Pathogenesis of Hepatic EncephalopathyJan Albrecht Ch. 3: Neuro-inflammation in the Pathogenesis of Hepatic Encephalopathy Roger Butterworth  Ch. 4: Inflammation and Hepatic Encephalopathy Debbie Lindsay ShawcrossShabnam S. ShabbirAmit Singh Seyan  Ch. 5: Oxidative Stress in Hepatic EncephalopathyMichael D. NorenbergArumugam R. Jayakumar  Ch. 6: The Role of Natural Benzodiazepines Receptor Ligands in Hepatic Encephalopathy E. Anthony JonesKevin D. Mullen  Section B: Diagnosis  Ch. 7: Diagnosis of Overt Hepatic EncephalopathyKarin Weissenborn Ch. 8: Diagnosis of Minimal Hepatic EncephalopathyJennifer Y. MontgomeryJasmohan S. Bajaj   Ch. 9: The Electroencephalogram in Hepatic EncephalopathyPiero Amodio Ch. 10: Brain Imaging in Hepatic EncephalopathyRita García-MartínezJuan Córdoba  Section C: Treatment  Ch. 11: Disaccharides in the treatment of hepatic encephalopathy Praveen SharmaShiv Kumar Sarin Ch. 12: Antibiotic Treatment for Hepatic EncephalopathyKevin D. MullenRavi K. Prakash  Ch. 13: Ornithine phenylacetate: A novel strategy for the treatment of Hepatic EncephalopathyMaria Jover-Cobos Nathan A. Davies Yalda SharifiRajiv Jalan   Section D: Special Topics  Ch. 14: Sleep Disorders and Hepatic EncephalopathySara Montagnese Ch. 15: Hepatic Encephalopathy and DrivingMatthew R. KappusJasmohan S. Bajaj Ch. 16: Nutrition and Hepatic EncephalopathyManuela MerliMichela GiustoOliviero Riggio Ch. 17:Hepatic Encephalopathy in Patients with Transjugular Intrahepatic Portosystemic Shunt (TIPS)Martin RössleWulf Euringer   Ch. 18: Quality of Life in Hepatic EncephalopathyJillian Kallman PriceZobair M. Younossi  Ch. 19: Liver transplantation and Hepatic EncephalopathyDileep K. AtluriKevin D. Mullen Ch. 20: Future of Hepatic EncephalopathyRavi K. PrakashKevin D. Mullen  Praveen SharmaShiv Kumar Sarin Ch. 12: Antibiotic Treatment for Hepatic EncephalopathyKevin D. MullenRavi K. Prakash  Ch. 13: Ornithine phenylacetate: A novel strategy for the treatment of Hepatic EncephalopathyMaria Jover-Cobos Nathan A. Davies Yalda SharifiRajiv Jalan   Section D: Special Topics  Ch. 14: Sleep Disorders and Hepatic EncephalopathySara Montagnese Ch. 15: Hepatic Encephalopathy and DrivingMatthew R. KappusJasmohan S. Bajaj Ch. 16: Nutrition and Hepatic EncephalopathyManuela MerliMichela GiustoOliviero Riggio Ch. 17:Hepatic Encephalopathy in Patients with Transjugular Intrahepatic Portosystemic Shunt (TIPS)Martin RössleWulf Euringer   Ch. 18: Quality of Life in Hepatic EncephalopathyJillian Kallman PriceZobair M. Younossi  Ch. 19: Liver transplantation and Hepatic EncephalopathyDileep K. AtluriKevin D. Mullen Ch. 20: Future of Hepatic EncephalopathyRavi K. PrakashKevin D. Mullen  Zobair M. Younossi  Ch. 19: Liver transplantation and Hepatic EncephalopathyDileep K. AtluriKevin D. Mullen Ch. 20: Future of Hepatic EncephalopathyRavi K. PrakashKevin D. Mullen  

Erscheint lt. Verlag 30.5.2012
Reihe/Serie Clinical Gastroenterology
Clinical Gastroenterology
Zusatzinfo XIV, 250 p.
Verlagsort New York
Sprache englisch
Themenwelt Medizin / Pharmazie Allgemeines / Lexika
Medizin / Pharmazie Medizinische Fachgebiete Allgemeinmedizin
Medizinische Fachgebiete Innere Medizin Gastroenterologie
Medizinische Fachgebiete Innere Medizin Hepatologie
Medizin / Pharmazie Medizinische Fachgebiete Neurologie
Studium 2. Studienabschnitt (Klinik) Pathologie
Schlagworte brain edema • chronic liver failure • covert hepatic encephalopathy • hepatology • pathogenesis • pathophysiology
ISBN-10 1-61779-836-3 / 1617798363
ISBN-13 978-1-61779-836-8 / 9781617798368
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