Histopathology of Nodal and Extranodal Non-Hodgkin’s Lymphomas

1 History of Lymphoma Classification.- 1.1 Introduction.- 1.2 The Kiel Classification.- 1.3 The REAL Classification Proposal.- 1.4 The WHO Classification.- References.- 2 Current Status of Lymphoma Classification.- 2.1 Introduction.- 2.2 Small- and Large-Cell Versus Low- and High-Grade.- 2.3 Primary Versus Secondary Lymphoma.- 2.4 Definition of Immunocytoma and Its Border with Marginal Zone B-Cell Lymphoma.- 2.5 Indistinct Border Between Nodal Marginal Zone B-Cell Lymphoma and Follicular Lymphoma with Marginal Zone Differentiation.- 2.6 Grading of Follicular Lymphoma.- 2.7 Distinction Between Diffuse Large B-Cell Lymphoma and Burkit’s Lymphoma: Reproducibility and Value of Subclassification.- 2.8 Problems in Reproducibly Recognizing Anaplastic Large-Cell Lymphoma and Lymphoblastic Lymphoma on Purely Morphological Grounds.- 2.9 Is Peripheral T-Cell Lymphoma, Unspecified a Distinct Clinicopathological Entity or a Catchall Term?.- 2.10 Neither the WHO nor the EORTC Classification of Cutaneous Lymphoma Covers Today’s Knowledge.- References.- 3 Epidemiology.- 3.1 Introduction.- 3.2 Statistical Data of the Kiel Lymphoma Registry.- References.- 4 Nodal B-Cell Lymphoma.- 4.1 Precursor B-Cell Lymphoblastic Leukemia.- 4.2 Peripheral B-Cell Lymphoma.- References.- 5 Nodal and Leukemic NK/T-Cell Lymphoma.- 5.1 Precursor T-Lymphoblastic Leukemia/Lymphoma.- 5.2 Peripheral NK/T-Cell Lymphoma.- References.- 6 Extranodal Lymphoma.- 6.1 Introduction.- 6.2 Gastrointestinal Lymphoma.- 6.3 Lymphoma of the Upper Aerodigestive Tract.- 6.4 Malignant Lymphoma of the Major Salivary Glands.- 6.5 Lymphoma of the Eye, Lachrymal Glands, and Orbit.- 6.6 Lymphoma of the Mediastinum.- 6.7 Lymphoma of the Lung.- 6.8 Lymphoma of the Pleura.- 6.9 Lymphoma of the Heart.- 6.10 Splenic Lymphoma.- 6.11Lymphoma of the Liver.- 6.12 Lymphoma of the Breast, Reproductive, and Urinary Systems.- 6.13 Endocrine Gland Lymphoma.- 6.14 Cutaneous Lymphoma.- 6.15 Lymphoma of Soft Tissues.- 6.16 Lymphoma of the Bone.- 6.17 Lymphoma of the Central Nervous System.- 6.18 Intravascular Large-B-Cell Malignant Lymphoma.- References.- 7 Plasma Cell Proliferations.- 7.1 Plasma Cell Myeloma/Bone Marrow Plasmacytoma.- 7.2 Extraosseous (Extramedullary) Plasmacytoma.- 7.3 Associated Diseases.- 7.4 Heavy-Chain Diseases.- References.- 8 Lymphoma Occurring in a Setting of Immunodeficiency.- 8.1 Lymphoproliferative Disorders Associated with Congenital Immunodeficiencies.- 8.2 Lymphoma and Lymphoproliferative Disorders Associated with Acquired Immunodeficiency.- References.- 9 Practical Guidelines for Lymphoma Diagnosis in Bone Marrow.- 9.1 Patterns of Involvement.- 9.2 Associated Lesions or Modifications.- 9.3 Diagnosis of Bone Marrow Involvement According to the Different Types of Lymphoma.- 9.4 Differential Diagnosis.- References.- 10 Practical Advice: Methods for the Diagnosis of Malignant Lymphoma.- 10.1 The Diagnosis of Malignant Lymphoma.- 10.2 Immunohistochemistry and Molecular Clonality Analysis in the Diagnosis of Lymphoma.- References.