Advances in Immunology

Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian cells, with a focus on the immune and nervous systems. Recently, his group has developed senstive genome-wide approaches to identify mechanisms of DNA breaks and rearrangements in normal and cancer cells. He has been elected to the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the European Molecular Biology Organization. His awards include the Albert Szent-Gyorgyi Prize for Progress in Cancer Research, the Novartis Prize for Basic Immunology, the Lewis S. Rosensteil Prize for Distinugished work in Biomedical Sciences, the Paul Berg and Arthur Kornberg Lifetime Achievement Award in Biomedical Sciences, and the William Silan Lifetime Achievement Award in Mentoring from Harvard Medical School.

The Immunobiology of IL-27Aisling O’Hara Hall, Jonathan S. Silver, and Christopher A. Hunter
Autoimmune Arthritis: The Interface between the Immune System and JointsNoriko Komatsu and Hiroshi Takayanagi
Immunological Tolerance during Fetal Development: From Mouse to ManJeff E. Mold and Joseph M. McCune
Mapping Lupus Susceptibility Genes in the NZM2410 Mouse ModelLaurence Morel
Functional Heterogeneity in the Basophil Cell LineageMark C. Siracusa, Elia D. Tait Wojno & David Artis
An Emerging Role of RNA-Binding Proteins as Multifunctional Regulators of Lymphocyte Development and FunctionMartin Turner and Daniel Hodson
Active and Passive Anti-cytokine Immune Therapies Current Status and DevelopmentHelene Le Buanec, Armand Bensussan, Martine Bagot, Robert C. Gallo, Daniel Zagury