Cancer and Aging Handbook

Keith M. Bellizzi, Ph.D, MPH, is Assistant Professor in the Department of Human Development & Family Studies at the University of Connecticut in Storrs, Connecticut. He wastrained in gerontology and epidemiology and he has spent the past several years in the Division of Cancer Control and Population Sciences at the National Cancer Institute, leading a division-wide cancer and aging initiative. Dr. Bellizzi is the current chair of theresearch on cancer and aging interest group of the Gerontological Society of America. He is also a co-investigator on the Medical Health Outcomes Study and Surveillance, Epidemiology and End Results (MHOS/SEER) Program examining the impact of cancer on pre-existing medical conditions in older adults.

Margot Gosney, MD, FRCP , is Professor of Elderly Care Medicine and Director of the Institute of Health Sciences in the University of Reading, UK. She is also a clinician working in Elderly Care at the Royal Berkshire Hospital NHS Foundation Trust inReading. Her research interests lie in the area of aging, and also include oncology, dental science for stroke patients, influenza, incontinence, falls and intellectual decline, and impaired vision and hearing. The association between nutrition and the health of elderly people has been a feature of Dr. Gosney's research and the University group has an international reputation for its findings in this area. She has published widely in peer-reviewed journals, has authored seven book chapters, and recently published Managing Older People in Primary Care: A Practical Guide.

FOREWORD ix

PREFACE xi

CONTRIBUTORS xiii

PART I CANCER AND AGING IN CONTEXT

1. Epidemiology of Cancer in the Older-Aged Person 3
Lodovico Balducci

2. Biological Aspects of Aging and Cancer 13
Gabriel Tinoco, Mya Thein, and William B. Ershler

3. Physiological, Psychological, and Social Aspects of Aging 35
George A. Kuchel, Julie Robison, and Richard Fortinsky

PART II STRATEGIES FOR CANCER PREVENTION IN OLDER ADULTS

4. Overview of Cancer Prevention Strategies in Older Adults 55
Barbara K. Dunn, Peter Greenwald, and Darrell E. Anderson

5. Breast Cancer Prevention 71
Jeanne F. Noe and Hyman B. Muss

6. Colorectal Cancer Prevention and Aging 85
Ernest T. Hawk, Sherri L. Patterson, Lopa Mishra, and Kush K. Patel

7. Prostate Cancer Prevention 97
Barbara Ercole and Ian M. Thompson, Jr.

8. Lung Cancer Prevention 105
Samira Shojaee and Konstantin H. Dragnev

PART III CANCER SCREENING GUIDELINES FOR OLDER ADULTS

9. Cancer in Older People: To Screen or Not to Screen? 117
Catherine Terret and Jean-Pierre Droz

10. Breast Cancer Screening 125
Heidi D. Nelson

11. Colorectal Cancer Screening 139
Catherine Quarini

12. Prostate Cancer Screening 153
Anthony B. Miller

13. Other Screening Opportunities for the Future 163
Catherine Quarini

PART IV CANCER TREATMENT

14. General Principles in Older Adults with Cancer 175
Martine Extermann

15. Surgery for Older Adults with Cancer 183
Lynda Wyld, Malcolm Walter Ronald Reed, and Thompson Gordon Robinson

16. Chemotherapy in Older Adults with Cancer 205
Matti S. Aapro and Hans Wildiers

17. Radiotherapy in Older Adults with Cancer 221
Ian Kunkler

PART V COMMON CANCERS IN THE ELDERLY

18. Breast Cancer 243
Laura Biganzoli, Catherine Oakman, Riccardo A. Audisio, and Ian Kunkler

19. Colon Cancer 269
Demetris Papamichael and Riccardo A. Audisio

20. Lung Cancer 283
Ulrich Wedding

21. Prostate Cancer 315
Nicolas Mottet and Jean-Pierre Droz

22. Ovarian Cancer 335
Claire Falandry, Gilles Freyer, and Eric Pujade-Lauraine

PART VI CANCER SURVIVORSHIP AND AGING

23. Theoretical Perspectives from Gerontology and Lifespan Development 349
Thomas O. Blank

24. Adaptation and Adjustment to Cancer in Later Life: A Conceptual Model 365
Gary T. Deimling, Boaz Kahana, and Karen Bowman

25. Long-Term and Late Physical and Psychosocial Effects of Cancer in Older Adults 385
Kerri M. Clough-Gorr and Rebecca A. Silliman

PART VII END-OF-LIFE CARE

26. Palliative Care for Cancer Patients and Their Families 403
Cardinale Smith and Diane Meier

27. Pain Management 419
Paul Glare, Beatriz Korc-Grodzicki, Nessa Coyle, and Manpreet Boparai

PART VIII EMERGING ISSUES

28. Caregiver Knowledge and Skills 447
Paula R. Sherwood, Barbara A. Given, and Charles W. Given

29. Comprehensive Geriatric Assessment 459
Lazzaro Repetto and Angela Marie Abbatecola

30. Economic Cost of Treating Older Adults with Cancer 475
Ya-Chen Tina Shih and Benjamin D. Smith

31. Multidisciplinary Models of Care 487
Kathleen Tschantz Unroe and Harvey Jay Cohen

INDEX 499

"Although these issues are absent, the book is well written and is an important resource for geriatric oncology clinicians. This book is the first of its kind, filling a gap and furthering the field of geriatric oncology." (Psycho-Oncology, 5 July 2013)