Haematology at a Glance

Atul B. Mehta and A. Victor Hoffbrand are both at the Royal Free and University College School of Medicine, Royal Free Hospital, London

Preface to the fourth edition 6

Preface to the first edition 6

Glossary 7

Normal values 8

About the companion website 9

Part 1 Basic physiology and practice

1 Haemopoiesis: physiology and pathology 10

2 Normal blood cells I: red cells 14

3 Normal blood cells II: granulocytes, monocytes and the reticuloendothelial system 18

4 Normal blood cells III: lymphocytes 20

5 Lymph nodes, the lymphatic system and the spleen 23

6 Clinical assessment 24

7 Laboratory assessment 26

Part 2 Red cell disorders

8 General aspects of anaemia 30

9 Iron I: physiology and deficiency 33

10 Iron II: overload and sideroblastic anaemia 36

11 Megaloblastic anaemia I: vitamin B 12 (B 12) and folate deficiency – biochemical basis, causes 38

12 Megaloblastic anaemia II: clinical features, treatment and other macrocytic anaemias 40

13 Haemolytic anaemias I: general 42

14 Haemolytic anaemias II: inherited membrane and enzyme defects 44

15 Haemolytic anaemias III: acquired 46

16 Haemolytic anaemias IV: genetic defects of haemoglobin – thalassaemia 48

17 Haemolytic anaemias V: genetic defects of haemoglobin – sickle cell disease 52

Part 3 Benign disorders of white cells

18 Benign disorders of white cells I: granulocytes, monocytes, macrophages 54

19 Benign disorders of white cells II: lymphocytes, lymph nodes, spleen, HIV 56

Part 4 Haematological malignancies

20 Introduction to Haematological malignancy: basic mechanisms 58

21 General aspects of treatment 61

22 Acute leukaemia I: classification and diagnosis 64

23 Acute leukaemia II: treatment and prognosis 68

24 Chronic Myeloid Leukaemia (BCR-ABL1 positive) 70

25 Myelodysplasia (myelodysplastic syndromes) 72

26 Myeloproliferative disorders I: introduction 74

27 Myeloproliferative disorders II: polycythaemia rubra vera 76

28 Myeloproliferative disorders III: essential thrombocythaemia, primary myelofibrosis and systemic mastocytosis 78

29 Chronic lymphocytic leukaemia 80

30 Multiple myeloma and plasma cell disorders 83

31 Lymphoma I: introduction 86

32 Lymphoma II: Hodgkin lymphoma 88

33 Lymphoma III: non-Hodgkin lymphoma – aetiology and classification 90

34 Lymphoma IV: clinical and laboratory features of more common subtypes 92

35 Lymphoma V: treatment and prognosis 94

Part 5 Treatment and procedures

36 Bone marrow failure 96

37 Haematological effects of drugs 98

38 Stem cell transplantation 100

Part 6 Haemostasis

39 Normal haemostasis I: vessel wall and platelets 102

40 Normal haemostasis II: coagulation factors and fibrinolysis 104

41 Disorders of haemostasis I: vessel wall and platelets 106

42 Disorders of haemostasis II: inherited disorders of coagulation 108

43 Disorders of haemostasis III: acquired disorders of coagulation 110

44 Thrombosis and anti-thrombotic therapy 112

45 Anticoagulation 115

Part 7 Haematological aspects of tropical disease

46 Haematological aspects of tropical diseases 118

47 Haematology of pregnancy and infancy 120

Part 8 Blood transfusion

48 Blood transfusion I 122

49 Blood transfusion II 124

Appendix: cluster of differentiation nomenclature system 127

Index 129