Epigenetics in Human Disease
Academic Press Inc (Verlag)
978-0-12-388415-2 (ISBN)
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Epigenetics is one of the fastest growing fields of sciences, illuminating studies of human diseases by looking beyond genetic make-up and acknowledging that outside factors play a role in gene expression. The goal of this volume is to highlight those diseases or conditions for which we have advanced knowledge of epigenetic factors such as cancer, autoimmune disorders and aging as well as those that are yielding exciting breakthroughs in epigenetics such as diabetes, neurobiological disorders and cardiovascular disease. Where applicable, attempts are made to not only detail the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, but also novel epigenetic approaches to the treatment of these diseases. Chapters are also presented on human imprinting disorders, respiratory diseases, infectious diseases and gynecological and reproductive diseases. Since epigenetics plays a major role in the aging process, advances in the epigenetics of aging are highly relevant to many age-related human diseases. Therefore, this volume closes with chapters on aging epigenetics and breakthroughs that have been made to delay the aging process through epigenetic approaches. With its translational focus, this book will serve as valuable reference for both basic scientists and clinicians alike.
Dr. Tollefsbol is a Distinguished Professor of Biology and a Senior Scientist in the O’Neal Comprehensive Cancer Center, Integrative Center for Aging Research, Nutrition Obesity Research Center, University Wide Microbiome Center, and the Comprehensive Diabetes Center at the University of Alabama at Birmingham (UAB). He is Director of the UAB Cell Senescence Culture Facility which he established in 1999. Dr. Tollefsbol trained as a Postdoctoral Fellow and Assistant Research Professor with members of the National Academy of Science at Duke University and the University of North Carolina. He earned doctorates in molecular biology and osteopathic medicine from the University of North Texas Health Sciences Center and his bachelor’s degree in Biology from the University of Houston. He has received prior funding from the NCI, NHLBI, NIMH and other federal institutes as well as the Glenn Foundation for Medical Research, Susan G. Komen for the Cure, the American Federation for Aging Research (AFAR), and the American Institute for Cancer Research (AICR) among many other sources.
Epigenetics of Human Disease
Methods and Strategies to Determine Epigenetic Variation in Human Disease
DNA Methylation Alterations in Human Cancers
Alterations of Histone Modifications in Cancer
MicroRNA in Oncogenesis
Epigenetic Approaches to Cancer Therapy
Epigenomics in Neurobehavioral Diseases
Emerging Role of Epigenetics in Human Neurodevelopmental Disorders
The Epigenetics of Alzheimer’s Disease
Epigenetic Modulation of Human Neurobiological Disorders
Epigenetic Basis of Autoimmune Disorders in Humans
Approaches to Autoimmune Diseases Using Epigenetic Therapy
Epigenetic Mechanisms of Human Imprinting Disorders
Epigenomic Factors in Human Obesity
Epigenetic Approaches to Control Obesity
Epigenetics of Diabetes in Humans
The Potential of Epigenetic Compounds in Treating Diabetes
Epigenetic Aberrations in Human Allergic Diseases,
Therapy of Airway Disease: Epigenetic Potential
The Role of Epigenetics in Cardiovascular Disease
Epigenetics and Human Infectious Diseases
The Epigenetics of Endometriosis
Aberrant DNA Methylation in Endometrial Cancer
Stem Cell Epigenetics and Human Disease
Non-Coding RNA Regulatory Networks, Epigenetics, and Programming Stem Cell Renewal and Differentiation: Implications for Stem Cell Therapy
Aging and Disease: The Epigenetic Bridge
Early-Life Epigenetic Programming of Human Disease and Aging
| Erscheint lt. Verlag | 14.9.2012 |
|---|---|
| Reihe/Serie | Translational Epigenetics |
| Verlagsort | San Diego |
| Sprache | englisch |
| Maße | 216 x 276 mm |
| Gewicht | 1890 g |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete |
| Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik | |
| Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie | |
| ISBN-10 | 0-12-388415-2 / 0123884152 |
| ISBN-13 | 978-0-12-388415-2 / 9780123884152 |
| Zustand | Neuware |
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