The Complement FactsBook

Scott Barnum received his B.S. in Biology (cum laude) from Loyola University in Maryland and his Ph.D. from the University of Alabama at Birmingham where he worked on the biosynthesis of factor D for his thesis studies. He then pursued postdoctoral studies on the genomic organization of several complement genes in the Department of Immunology at the Scripps Research Institute. He returned to UAB as a member of the faculty in the Department of Microbiology and holds secondary appointments in the Department of Neurology and the Division of Clinical Immunology and Rheumatology. Since returning to UAB, Dr. Barnum’s research has focused primarily on the role of complement in the central nervous system. Through a combination of in vitro and in vivo studies, his lab demonstrated that glia cells and neurons produce a variety of complement proteins and receptors. Subsequently, the lab identified the role of complement in numerous animal models of human disease including, traumatic brain injury, multiple sclerosis, bacterial meningitis, stroke, and cerebral malaria. In addition to numerous teaching awards, he produced the first high quality animated videos for teaching complement activation and biological functions. Dr. Barnum is currently working on the development of complement diagnostics for use in a variety of infectious disease and autoimmune indications.

Abbreviations.
Preface.
Section 1: The Introductory Chapters
B.J. Morley and M. Walport, Introduction.
B.J. Morely and M. Walport, The Complement System.
Section II: The Complement Proteins
Part 1: C1q and the Collectins
F. Petry and M. Loos, C1q.
P. Lawson and K.B.M. Reid, Mannose-binding Lectin.
P. Lawson and K.B.M. Reid, Bovine Conglutinin.
R.B. Sim, SP-A.
R.B. Sim, SP-D.
Part 2: Serine Proteases
N. Thielens and G.J. Arlaud, C1r.
N. Thielens and G.J. Arlaud, C1s.
T. Fujita, MASP-1.
S. Petersen and J. Jensenius, MASP-2.
J. Schifferli and S. Niot, Factor D.
Y. Xu Ma and J.E. Volanakis, C2.
A. Circolo and H.R. Colten, Factor B.
B.J. Morley, Factor I.
Part 3: C3 Family
M. Botto, C3.
R.A. Wetsel, C5.
Part 4: Terminal Pathway Components
M. Hobart, C6.
M. Hobart, C7.
F. Tedesco, M.E. Plumb, and J.M. Sodetz, C8.
B.P. Morgan, C9.
Part 5: Regulations of Complement Activation (RCA)
L.B. Klickstein, CR1.
J.M. Guthridge and V.M. Holers, CR2.
L. Kuttner-Kondo, W.G. Brodbeck, and M.E. Medof, Decay-accelerating Factor.
M.K. Liszewski and J.P. Atkinson, Membrane Cofactor Protein.
S. Rodriguez de Cordoba, O. Criado Garcia, and P. Sanchez-Corral, C4b-binding Protein.
R.G. DiScipio, Factor H.
Part 6: Cell Surface Receptors
A.J. Tenner, C1qRp.
R.S. Ames, C3aReceptor.
A. Klos and W. Bautsch, C5a Receptor.
Y. Xia and G. Ross, CR3.
A. Law, CR4.
Part 7: Miscellaneous Complement Components
R. Zahedi and A.E. Davis III, C1 Inhibitor.
M.E. Rosenberg, Apolipoprotein J (Clusterin).
T. Farries, Properdin.
B.P. Morgan, CD59.
Index.