Bispecific Antibodies (eBook)

Janice M. Reichert: Foreword.- Roland Kontermann: Bispecific antibodies: developments and current perspectives.- Gerd Moldenhauer: Bispecific antibodies from hybrid hybridoma.- Diego Ellerman & Justin Scheer: Generation of bispecific antibodies by chemical conjugation.- Christoph Stein, Ingo Schubert & Georg Fey: Trivalent and trispecific antibody derivatives for cancer therapy.- Dafne Müller & Roland Kontermann: Diabodies, single-chain diabodies and their derivatives.- Patrick Chames & Daniel Baty: Bispecific single domain antibodies.- John Löfblom & Fredrik Y. Frejd: Alternative scaffolds as bispecific antibody mimetics.- Nico Mertens: Tribodies: building trispecificity by Fab-scFv fusions.- Pei Jin & Zhenping Zhu: The design and engineering of IgG-like bispecific antibodies.- Edit Tarcsa, Wolfgang Fraunhofer, Tariq Ghayur, Jochen Salfeld & Jijie Gu: Dual-variable-domain immunoglobulin (DVD-IgTM) technology: a versatile, novel format for the next generation of dual-targeting biologics.- Patrick Koenig & Germaine Fuh: Two-in-one antibodies.- Chien-Hsing Chang, Edmund A. Rossi, Robert Sharkey & David M. Goldenberg: The Dock-and-Lock (DNL) approach to novel bispecifc antibodies.- Christian Kellner, Matthias Peipp & Thomas Valerius: Effector cell recruitment by bispecific antibodies.- Lawrence Lum & Archana Thakur: Bispecific anibodies for arming activated T cells and other effector cells for tumor therapy.- Patrick Baeuerle, Gerhard Zugmaier & Dominik Rüttinger: Bispecific T cell engager for cancer therapy.- Horst Lindhofer, Jürgen Hess & Peter Ruf: Trifunctional Triomab® antibodies for cancer therapy.- Bruno Robert, Christel Larbouret, David Azria, Jean-Pierre Mach & André Pèlegrin: Bispecific antibodies for the retargeting of cytokines.- Dirk Nettelbeck: Bispecific antibodies and gene therapy.- Archana Parashar, Susmita Sarkar, Advaita Ganguly, Saikiran Sharma & Mavanur R. Suresh: Bispecific antibodies for diagnostic applications.