Comparative Pathophysiology and Toxicology of Cycl ooxygenases

A key ingredient in common pain relievers such as aspirin and Tylenol, cyclooxygenase (COX) inhibitors can pose potential risks as evidenced by Merck's highly publicized 2004 withdrawal of their drug Vioxx. This book addresses the need in the medical and scientific communities for an up-to-date resource on drug safety and the comparative aspects of prostanoids research and COX inhibitors. It offers a thorough review of COX inhibitors, their toxicity mechanisms, and clinical risks, helping scientists advance research and discovery of COX drugs, while avoiding adverse pathological and toxicological effects.