Epigenetic Epidemiology (eBook)

Karin B. Michels (Herausgeber)

eBook Download: PDF
2012 | 2012
XII, 448 Seiten
Springer Netherland (Verlag)
978-94-007-2495-2 (ISBN)

Lese- und Medienproben

Epigenetic Epidemiology -
Systemvoraussetzungen
149,79 inkl. MwSt
  • Download sofort lieferbar
  • Zahlungsarten anzeigen

The exploding field of epigenetics is challenging the dogma of traditional Mendelian inheritance.  Epigenetics plays an  important role in shaping who we are and contributes to our prospects of health and disease.  While early epigenetic research focused on plant and animal models and in vitro experiments, population-based epidemiologic studies increasingly incorporate epigenetic components.  The relevance of epigenetic marks, such as DNA methylation, genomic imprinting, and histone modification for disease causation has yet to be fully explored. This book covers the basic concepts of epigenetic epidemiology, discusses challenges in study design, analysis, and interpretation, epigenetic laboratory techniques, the influence of of age and environmental factors on shaping the epigenome, the role of epigenetics in the developmental origins hypothesis, and provides the state of the art on the epigenetic epidemiology of various health conditions including childhood syndromes, cancer, infectious diseases, inflammation and rheumatoid arthritis, asthma, autism and other neurodevelopmental disorders, psychiatric disorders, diabetes, obesity and metabolic disorders, and atherosclerosis.

With contributions from: Peter Jones, Jean-Pierre Issa, Gavin Kelsey, Robert Waterland, and many other experts in epigenetics!


The exploding field of epigenetics is challenging the dogma of traditional Mendelian inheritance. Epigenetics plays an important role in shaping who we are and contributes to our prospects of health and disease.  While early epigenetic research focused on plant and animal models and in vitro experiments, population-based epidemiologic studies increasingly incorporate epigenetic components. The relevance of epigenetic marks, such as DNA methylation, genomic imprinting, and histone modification for disease causation has yet to be fully explored.This book covers the basic concepts of epigenetic epidemiology, discusses challenges in study design, analysis, and interpretation, epigenetic laboratory techniques, the influence of age and environmental factors on shaping the epigenome, the role of epigenetics in the developmental origins hypothesis, and provides the state of the art on the epigenetic epidemiology of various health conditions including childhood syndromes, cancer, infectious diseases, inflammation and rheumatoid arthritis, asthma, autism and other neurodevelopmental disorders, psychiatric disorders, diabetes, obesity and metabolic disorders, and atherosclerosis.With contributions from: Peter Jones, Jean-Pierre Issa, Gavin Kelsey, Robert Waterland, and many other experts in epigenetics!

Introduction.-1. The Human Epigenome.-2. Considerations in the Design, Conduct, and Interpretation of Studies in Epigenetic Epidemiology.-3. Laboratory methods in epigenetic epidemiology.-4. Biostatistical methods in epigenetic epidemiology.-5. Epigenome changes during development.-6. The role of epigenetics in the developmental origins of health and disease.-7. Epigenetics and assisted reproductive technology.-8. Imprinting disorders of early childhood.-9. The utility of twins for epigenetic analysis.-10. Changes in the epigenetic profile with age.-11. Influence of environmental factors on the epigenome.-12. Epigenetic epidemiology of cancer.-13. Epigenetic epidemiology of infectious diseases.-14. Epigenetic epidemiology of inflammation and rheumatoid arthritis.-15. Asthma epigenetics: Emergence of a new paradigm? -16. Epigenetic epidemiology of autism and other neurodevelopmental disorders.-17. Epigenetic epidemiology of psychiatric disorders.-18. Epigenetic epidemiology of type 1 diabetes.-19. Epigenetic epidemiology of obesity, type 2 diabetes, and metabolic disorders.-20. Epigenetic epidemiology of atherosclerosis. Index.

Erscheint lt. Verlag 2.1.2012
Zusatzinfo XII, 448 p.
Verlagsort Dordrecht
Sprache englisch
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Onkologie
Studium 1. Studienabschnitt (Vorklinik) Biochemie / Molekularbiologie
Studium 2. Studienabschnitt (Klinik) Humangenetik
Studium Querschnittsbereiche Epidemiologie / Med. Biometrie
Schlagworte Basic science • epidemiology • epigenetics • Human Research • prevention
ISBN-10 94-007-2495-0 / 9400724950
ISBN-13 978-94-007-2495-2 / 9789400724952
Informationen gemäß Produktsicherheitsverordnung (GPSR)
Haben Sie eine Frage zum Produkt?
PDFPDF (Wasserzeichen)
Größe: 6,9 MB

DRM: Digitales Wasserzeichen
Dieses eBook enthält ein digitales Wasser­zeichen und ist damit für Sie persona­lisiert. Bei einer missbräuch­lichen Weiter­gabe des eBooks an Dritte ist eine Rück­ver­folgung an die Quelle möglich.

Dateiformat: PDF (Portable Document Format)
Mit einem festen Seiten­layout eignet sich die PDF besonders für Fach­bücher mit Spalten, Tabellen und Abbild­ungen. Eine PDF kann auf fast allen Geräten ange­zeigt werden, ist aber für kleine Displays (Smart­phone, eReader) nur einge­schränkt geeignet.

Systemvoraussetzungen:
PC/Mac: Mit einem PC oder Mac können Sie dieses eBook lesen. Sie benötigen dafür einen PDF-Viewer - z.B. den Adobe Reader oder Adobe Digital Editions.
eReader: Dieses eBook kann mit (fast) allen eBook-Readern gelesen werden. Mit dem amazon-Kindle ist es aber nicht kompatibel.
Smartphone/Tablet: Egal ob Apple oder Android, dieses eBook können Sie lesen. Sie benötigen dafür einen PDF-Viewer - z.B. die kostenlose Adobe Digital Editions-App.

Buying eBooks from abroad
For tax law reasons we can sell eBooks just within Germany and Switzerland. Regrettably we cannot fulfill eBook-orders from other countries.

Mehr entdecken
aus dem Bereich
Das Lehrbuch für das Medizinstudium

von Florian Horn

eBook Download (2020)
Georg Thieme Verlag KG
69,99
Das Lehrbuch für das Medizinstudium

von Florian Horn

eBook Download (2020)
Georg Thieme Verlag KG
69,99