Infected Total Joint Arthroplasty

Mr. Rihard Trebše MD, MSc, Orthopedic hospital Valdoltra

Introduction.- Joint replacements - historical overview.- Biomaterials in artificial joint replacements.- The definition of prosthetic joint infections (PJIs).- Classifications of prosthetic joint infections.- The epidemiology of total joint arthroplasty infections.- Septic complications in arthroplasty.- Perioperative antibiotic prophylaxis in total joint arthroplasty.- Risk factors for prosthetic joint infections.- Pathogenesis of prosthetic joint infections.- Bacteria-biomaterial interactions.- Biomaterial-host interactions in aseptic and septic conditions.- Influence of wear particles on local and systemic immune system.- Diagnostic evaluations.- Sinovial fluid cytology.- Histological analysis of periprosthetic tissue for detecting prosthetic joint infection.- Microbiological diagnosis of  prosthetic joint infection.- Microbiological processing of samples in the investigation of suspected prosthetic joint infections.- Molecular diagnosis of prosthetic joint infection.- Current treatment strategies in prosthetic joint infections.- Total ankle replacement infections.- Periprosthetic Infection Issues With Osseointegrated (OI) Implant Technology in Amputees.- The algorithm for diagnostic evaluation and treatment.- Bone grafts and bone graft substitutes in infected arthroplasty.- Pitfalls of antimicrobial therapy in infected joint artroplasty.