Thrombosis and Thrombolysis

1. Molecular mechanisms of fibrin polymerization and anticoagulant action of fibrinogen and fibrin degradation products.- 2. Nonenzymatic fibrinolysis and its role in the organism.- 3. Mechanisms of enzymatic fibrinolysis.- 4. Leeches Hirudo medicinalis as a source of proteolytic enzyme inhibitors.- 5. Development of biocompatible preparations of immobilized enzymes and clinical results with immobilized streptokinase (streptodecase).- 6. Thrombolytic activity of proteinases immobilized on water-soluble matrices.- 7. Fibrinolytically active polymers.- 8. Microbiological synthesis of proteolytic enzymes possessing fibrinolytic activity.- 9. Prospects of using antivitamins K in the treat-ment of intravascular thrombosis.- 10. Apheresis techniques (gravitation surgery) in the regulation of the hypercoagulable (blood aggregate) state.- 11. Pharmacodynamic characteristics of urokinin.- 12. Plasmakinase: a new thrombolytic preparation from postmortem plasma.- 13. Inhibitors of platelet aggregation.- 14. Platelet spreading and the formation of thrombi- like aggregates on a collagen substrate. Effect of soluble inducers of platelet activity under different hydrodynamic conditions.- 15. Impaired platelet adhesion to collagen-coated surface in patients with bleeding duodenal ulcer (direct measurement of platelet adhesion in a Coulter-type cell counter following elution of adherent platelets).- 16. Biological properties and thrombolytic activity of proteinase from Aspergillus terricola.