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Progestins and Antiprogestins in Clinical Practice

Buch | Hardcover
424 Seiten
1999
Marcel Dekker Inc (Verlag)
978-0-8247-8291-7 (ISBN)
133,40 inkl. MwSt
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Examines the physiological aspects of progestins and their role at the receptor level, focusing on reproductive activity, menopausal treatment, and related areas. This book explains the effects of long-term controlled progestin studies on breast tissue; discusses the nuclear localization of steroid hormone receptors; and more.
This comprehensive ready-reference guide thoroughly examines the physiological aspects of progestins and their role at the receptor level, focusing on reproductive activity, menopausal treatment, and related areas. The book presents vital research findings on the clinical use of progesterone and related derivatives, plus key applications of antiprogestins.
Illuminates progesterone's remarkable power in hormonal contraception and regulation of the hypothalamo-pituitary complex!
Written by more than 25 leading international experts on women's health, Progestins and Antiprogestins in Clinical Practice
explains the effects of long-term controlled progestin studies on breast tissue

discusses the nuclear localization of steroid hormone receptors

covers the relationship of CDK activity and cell proliferation

analyzes production of progesterone metabolites and precursors synthesized locally within the brain and in the endocrine glands

describes cardiovascular effects associated with combined oral contraceptives (COCs), highlighting carbohydrate and lipid metabolism and hematological factors

investigates the epidemiology of estrogen-induced endometrial hyperplasia and/or cancer

demonstrates cases in which minor structural modifications in some steroid molecules can affect biological function

explores several properties of progesterone and its natural derivatives

illustrates instances of cloning of the intracellular progesterone receptor (PR) in several species

assesses direct progesterone action in target tissues and indirect effects of progesterone regulation

surveys properties of widely used contraceptive steroids, such as norethindrone (NET) plus estradiol (E2), levonorgestrel (LNG) plus estradiol (E2), nestorone plus ethinyl estradiol (EE2), and NET acetate plus EE2

reviews the efficacy and safety of newer contraceptive strategies such as Norplant implants and vaginal rings

covers applications of RU486 (mifepristone)

and more!

Physiological Aspects

Structure of the Progesterone Receptor and Mode of Action of Progesterone,
Anne Guiochon-Mantel
Effects of Progesterone and Related Steroids in the Brain,
Martine El-Etr, Michaël Schumacher, and Etienne-Emile Baulieu
Effects of Progestin on the Breast: Regulation of Cell Cycle Progression by Progestins,
Elizabeth A. Musgrove and Robert L. Sutherland
Vaginal Progesterone: Direct Access to the Uterus, Physiological Hormone Replacement in Infertility and Gynecology,
Dominique de Ziegler, Carlo Bulletti, and Ettore Cicinelli

Pharmacology of Synthetic Progestins

Pharmacology of Progestins: 17 -Hydroxyprogesterone Derivatives and Progestins of the First and Second Generation,
Milan Rastislav Henzl and John A. Edwards
Clinical Pharmacology of Third-Generation Gestogens,
Kenneth Fotherby
Pharmacology of New Progestogens: The 19-Norprogesterone Derivatives,
Régine Sitruk-Ware and Kalyan Sundaram
Hybrid Progestins: The Example of Dienogest,
Michael Oettel and Cornelia Holz

Clinical Applications

Contraception

Progestogens in Contraception: Third-Generation Pills,
Ulysse J. Gaspard
Levonorgestrel-Releasing Contraceptive Implants,
C. Wayne Bardin
Progestin-Releasing Intrauterine Devices,
Tapani Luukkainen
Contraceptive Vaginal Rings,
Donna Shoupe and Daniel R. Mishell, Jr.
Progestins for Emergency Contraception,
André Ulmann

Menopause

Progestins in Hormonal Replacement Therapy and Prevention of Endometrial Disease,
Régine Sitruk-Ware
Progestins in Postmenopausal Women: Epidemiological Data on Relationships with Endometrial and Breast Cancer Risk,
Timothy J. Key
Progestins in Hormonal Replacement Therapy and Cardiovascular Risk,
Régine Sitruk-Ware

Breast Diseases

Control of Estrogen's Effects by Progestins in Breast Cancer,
Jorge R. Pasqualini
Epidemiology and Treatment of Benign Breast Disease: Effect of Progestins on Breast Disease,
Régine Sitruk-Ware and Geneviève Plu-Bureau

Other Indications

Therapeutic Use of Progestins: Practical Recommendations,
Régine Sitruk-Ware

Metabolic Effects of Progestins

The Effect of Progestins on Plasma Lipids,
Matti J. Tikkanen
Hormonal Replacement Therapy and Glucose Metabolism in Postmenopausal Women,
Sven O. Skouby

Antiprogestins

Antiprogestins in Clinical Practice,
Irving M. Spitz and Ann Robbins

Pharmacokinetics

Pharmacokinetics of Progesterone Administered Orally and Parenterally,
Frank Z. Stanczyk

Verlagsort New York
Sprache englisch
Maße 216 x 279 mm
Gewicht 680 g
Themenwelt Medizinische Fachgebiete Innere Medizin Endokrinologie
Medizin / Pharmazie Medizinische Fachgebiete Pharmakologie / Pharmakotherapie
ISBN-10 0-8247-8291-7 / 0824782917
ISBN-13 978-0-8247-8291-7 / 9780824782917
Zustand Neuware
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