Epigenetic Contributions in Autoimmune Disease (eBook)

ESTEBAN BALESTAR is head of the Chromatin and Disease Group at the Cancer Epigenetics and Biology Programme (PEBC) of the Bellvitge Biomedical Research Institute (IDIBELL ) in Barcelona, Spain. Ballestar obtained his PhD degree from the University of Valencia under the supervision of Prof. Luis Franco, specialising in chromatin and histone modifications (1997). He then worked as a Postdoctoral Fellow at the National Institutes of Health, (Bethesda, MD, USA) in the laboratory of Dr. Alan Wolffe where he investigated associations between elements of the chromatin machinery and methylated DNA. From 2001 to 2008, Esteban Ballestar has worked at the CNIO Cancer Epigenetics Laboratory, in association with Dr. Manel Esteller, where his principal area of research has been the study of the implication of chromatin factors in epigenetic alterations in human cancer. His current research is devoted to the establishment of different mechanisms of epigenetic deregulation in the context of the hematopoietic system in both autoimmune diseases and hematological malignancies.

AN INTRODUCTION TO EPIGENETICS.- CHROMATIN MECHANISMS REGULATING GENE EXPRESSION IN HEALTH AND DISEASE.- EPIGENETIC CONTROL OF LYMPHOCYTE DIFERENTIATION.- EPIGENETIC CONTROL IN IMMUNE FUNCTION.- DNA METHYLATION AND B‑CELL AUTOR EACTIVITY.- ENVIRONMENTAL AGENTS AND AUTOIMMUNE DISEASES.- EPIGENETIC DYSREGULATION OF EPSTEIN‑BARR VIRUS LATENCY AND DEVELOPMENT OF AUTOIMMUNE DISEASE.- DOES GENOMIC IMPRINTING PLAY A ROLE IN AUTOIMMUNITY?.- A NEW EPIGENETIC CHALLENGE: SYSTEMIC LUPUS ERYTHEMATOSUS.- EPIGENETIC DEREGULATION IN RHEUMATOID ARTHRITIS.- PROSPECTS FOR EPIGENETIC COMPOUNDS IN THE TREATMENT OF AUTOIMMUNE DISEASE.- PROFILING EPIGENETIC ALTERATIONS IN DISEASE.