Kelley's Textbook of Rheumatology

VOLUME I STRUCTURE AND FUNCTION OF BONE, JOINTS, AND CONNECTIVE TISSUE, 1 1 Biology of the Normal Joint, 1 2 Synovium, 20 3 Cartilage and Chondrocytes, 33 4 Biology, Physiology, and Morphology of Bone, 61 5 Muscle: Anatomy, Physiology, and Biochemistry, 67 6 Biomechanics, 79 7 Regenerative Medicine and Tissue Engineering, 90 8 Proteinases and Matrix Degradation, 97 CELLS INVOLVED IN AUTOIMMUNE DISEASES AND INFLAMMATION, 117 9 Dendritic Cells, 117 10 Mononuclear Phagocytes in Rheumatic Diseases, 134 11 Neutrophils, 152 12 Eosinophils, 170 13 T Lymphocytes, 174 14 B Cells, 191 15 Fibroblasts and Fibroblast-like Synoviocytes, 215 16 Mast Cells, 232 17 Platelets, 245 EFFECTOR MECHANISMS IN AUTOIMMUNITY AND INFLAMMATION, 255 18 Innate Immunity, 255 19 Adaptive Immunity and Organization of Lymphoid Tissues, 268 20 Autoimmunity, 281 21 Genetics of Rheumatic Diseases, 299 22 Epigenetics, 316 23 Complement System, 325 24 Prostaglandins, Leukotrienes, and Related Compounds, 340 25 Cell Recruitment and Angiogenesis, 358 26 Cytokines, 369 27 Cell Survival and Death in Rheumatic Diseases , 382 28 Experimental Models for Rheumatoid Arthritis, 400 29 Neural Regulation of Pain and Infl ammation, 413 BROAD ISSUES IN THE APPROACH TO RHEUMATIC DISEASE, 431 30 Principles of Epidemiology in Rheumatic Disease, 431 31 Economic Burden of Rheumatic Diseases, 440 32 Clinical Trial Design and Analysis, 452 33 Assessment of Health Outcomes, 462 34 Biologic Markers, 476 35 Occupational and Recreational Musculoskeletal Disorders, 493 36 Cardiovascular Risk in Rheumatic Disease, 505 37 Cancer Risk in Rheumatic Diseases, 515 38 Introduction to Physical Medicine, Physical Therapy, and Rehabilitation, 528 39 Pregnancy in the Rheumatic Diseases, 540 EVALUATION OF GENERALIZED AND LOCALIZED SYMPTOMS, 559 40 History and Physical Examination of the Musculoskeletal System, 559 41 Acute Monoarthritis, 577 42 Polyarticular Arthritis, 587 43 The Skin and Rheumatic Diseases, 599 44 The Eye and Rheumatic Diseases, 617 DIFFERENTIAL DIAGNOSIS OF REGIONAL AND DIFFUSE MUSCULOSKELETAL PAIN, 625 45 Neck Pain, 625 46 Shoulder Pain, 639 47 Low Back Pain, 665 48 Hip and Knee Pain, 683 49 Foot and Ankle Pain, 700 50 Hand and Wrist Pain, 708 51 Temporomandibular Joint Pain, 721 52 Fibromyalgia, 733 DIAGNOSTIC TESTS AND PROCEDURES IN RHEUMATIC DISEASES, 753 53 Synovial Fluid Analyses, Synovial Biopsy, and Synovial Pathology , 753 54 Arthrocentesis and Injection of Joints and Soft Tissue, 770 55 Antinuclear Antibodies, 789 56 Autoantibodies in Rheumatoid Arthritis, 804 57 Acute Phase Reactants and the Concept of Infl ammation, 818 58 Imaging Modalities in Rheumatic Diseases , 830 PHARMACOLOGY OF ANTIRHEUMATIC DRUGS, 871 59 Prostanoid Biology and Its Therapeutic Targeting, 871 60 Glucocorticoid Therapy, 894 61 Traditional DMARDs: Methotrexate, Lefl unomide, Sulfasalazine, Hydroxychloroquine, and Combination Therapies, 917 62 Immunosuppressive Drugs, 941 63 Anticytokine Therapies, 957 64 Cell-Targeted Biologics and Targets: Rituximab, Abatacept, and Other Biologics, 978 65 Antihyperuricemic Agents, 1001 66 Analgesic Agents in Rheumatic Disease, 1014 67 Psychosocial Management of Rheumatic Diseases, 1034 68 Nutrition and Rheumatic Diseases, 1044 VOLUME II RHEUMATOID ARTHRITIS, 1059 69 Etiology and Pathogenesis of Rheumatoid Arthritis , 1059 70 Clinical Features of Rheumatoid Arthritis , 1109 71 Treatment of Rheumatoid Arthritis, 1137 72 Early Synovitis and Early Undifferentiated Arthritis, 1161 73 Sjogren's Syndrome, 1169 SPONDYLOARTHROPATHIES, 1193 74 Pathogenesis of Ankylosing Spondylitis and Reactive Arthritis, 1193 75 Ankylosing Spondylitis, 1202 76 Reactive Arthritis and Undifferentiated Spondyloarthritis, 1221 77 Psoriatic Arthritis, 1232 78 Enteropathic Arthritis, 1251 SYSTEMIC LUPUS ERYTHEMATOSUS AND RELATED SYNDROMES, 1269 79 Etiology and Pathogenesis of Systemic Lupus Erythematosus, 1269 80 Clinical Features of Systemic Lupus Erythematosus, 1283 81 Treatment of Systemic Lupus Erythematosus, 1304 82 Antiphospholipid Syndrome, 1331 SCLERODERMA, INFLAMMATORY MYOPATHIES, AND OVERLAP SYNDROMES, 1343 83 Etiology and Pathogenesis of Scleroderma, 1343 84 Clinical Features and Treatment of Scleroderma, 1366 85 Infl ammatory Diseases of Muscle and Other Myopathies, 1404 86 Overlap Syndromes, 1431 VASCULITIS, 1453 87 Classifi cation and Epidemiology of Systemic Vasculitis, 1453 88 Giant Cell Arteritis, Polymyalgia Rheumatica, and Takayasu's Arteritis, 1461 89 Antineutrophil Cytoplasm Antibody-Associated Vasculitis, 1481 90 Polyarteritis Nodosa and Related Disorders, 1498 91 Immune Complex-Mediated Small Vessel Vasculitis, 1508 92 Primary Angiitis of the Central Nervous System, 1518 93 Behcet's Disease, 1525 CRYSTAL-INDUCED AND INFLAMMASOME-MEDIATED INFLAMMATION, 1533 94 Etiology and Pathogenesis of Hyperuricemia and Gout , 1533 95 Clinical Features and Treatment of Gout, 1554 96 Calcium Crystal Disease: Calcium Pyrophosphate Dihydrate and Basic Calcium Phosphate , 1576 97 Familial Autoinfl ammatory Syndromes, 1597 CARTILAGE, BONE, AND HERITABLE CONNECTIVE TISSUE DISORDERS, 1617 98 Pathogenesis of Osteoarthritis, 1617 99 Clinical Features of Osteoarthritis, 1636 100 Treatment of Osteoarthritis , 1646 101 Metabolic Bone Disease, 1660 102 Proliferative Bone Diseases, 1680 103 Osteonecrosis, 1692 104 Relapsing Polychondritis , 1712 105 Heritable Diseases of Connective Tissue, 1719 RHEUMATIC DISEASES OF CHILDHOOD, 1741 106 Etiology and Pathogenesis of Juvenile Idiopathic Arthritis, 1741 107 Treatment of Juvenile Idiopathic Arthritis, 1752 108 Pediatric Systemic Lupus Erythematosus, Dermatomyositis, Scleroderma, and Vasculitis, 1771 INFECTION AND ARTHRITIS, 1801 109 Bacterial Arthritis, 1801 110 Lyme Disease, 1815 111 Mycobacterial Infections of Bones and Joints, 1829 112 Fungal Infections of Bones and Joints, 1841 113 Rheumatic Manifestations of Human Immunodefi ciency Virus Infection, 1851 114 Viral Arthritis, 1865 115 Poststreptococcal Arthritis and Rheumatic Fever, 1875 ARTHRITIS ACCOMPANYING SYSTEMIC DISEASE, 1889 116 Amyloidosis, 1889 117 Sarcoidosis , 1898 118 Hemochromatosis, 1907 119 Hemophilic Arthropathy, 1915 120 Rheumatologic Manifestations of Hemoglobinopathies, 1924 121 Endocrine Diseases and the Musculoskeletal System, 1927 122 Musculoskeletal Syndromes in Malignancy, 1934 123 Tumors and Tumor-like Lesions of Joints and Related Structures, 1951