Genome Integrity (eBook)

Replication.- Chromosomal DNA Replication: On Replicases, Replisomes, and Bidirectional Replication Factories.- Progress Towards the Anatomy of the Eukaryotic DNA Replication Fork.- DNA Polymerases and Diseases.- Replicative Double-Strand Break Repair.- Facing Stalled Replication Forks: The Intricacies of Doing the Right Thing.- Germline Double-Strand Break Repair and Gene Targeting in Drosophila: A Trajectory System throughout Evolution.- Facets of Double-Strand Break Repair.- Structure and Function of Rad50/SMC Protein Complexes in Chromosome Biology.- Mechanisms of Non-Homologous DNA End Joining:Aspects of In Vitro Assays.- Role of p53 in Double-Strand Break Repair.- The Role of Chromatin Structure and Nuclear Architecture in the Cellular Response to DNA Double-Strand Breaks.- DNA Repair and Pleiotropic Interactions.- DNA Base Damage Recognition and Processing.- Inter- and Supramolecular Interactions of Protein Kinase CK2 and their Relevance for Genome Integrity.- Role of Human Topoisomerase I in DNA Repair and Apoptosis.- Genomic Instability in Fanconi Anaemia and Nijmegen Breakage Syndrome.- Radiation and other Genotoxic Stress.- Induction of DNA Repair Genes in Mammalian Cells in Response to Genotoxic Stress.- Pathways of DNA Double-Strand Break Repair in Mammalian Cells after Ionizing Radiation.- Genomic Instability:Signaling Pathways Orchestrating the Responsesto Ionizing Radiation and Cisplatin.- Ion Irradiation as a Tool to Reveal the Spatiotemporal Dynamics of DNA Damage Response Processes.