Tumors of the Brain and Spine (eBook)
XII, 364 Seiten
Springer US (Verlag)
978-0-387-29202-1 (ISBN)
Tumors of the Brain and Spine focuses primarily on approaches to the treatment of benign, primary low-grade to high-grade, and metastatic tumors in the brain and spine, as practiced by surgeons and clinicians at the University of Texas M. D. Anderson Cancer Center. The book is written mainly for the primary care oncologist, general neurologist, and general neurosurgeon. Discussion of treatment coverage focuses on neurosurgery, chemotherapy, and radiation therapy, singly and in combination. Also included are chapters on symptom management, molecular genetics and neuropathology of intracranial tumors, leptomeningeal dissemination of systemic cancer, epidemiology of brain tumors, and innovative treatment strategies.
It is frequently stated that progress in the management of tumors of the brain and spine has not occurred in the past 25 years. Such statements seriously underestimate and misrepresent progress in managing various central nervous system tumors, the tremendous technologic enhancements that have revolutionized the imaging of the tumors and the host organ, the multitude of surgical adjuncts such as computerized imaging guidance and functional mapping of the brain and its tracts that are routinely used in the modern neurosurgical operating room, and the highly conformal delivery of radiation to the tumor mass with remarkable sparing of the surrounding nervous tissue. Underlying these technologic improvements are the changes in philosophy that have resulted in a true multidisciplinary approach. Equally significant is the molecular revolution that is identifying key markers behind the genesis of brain tumors, their proliferation, and their resistance to therapy. These molecular discoveries have ushered in the era of molecular targeted therapy, as first demonstrated by the extraordinary success story in chronic myelogenous leukemia of imatinib (Gleevec). The rational combination of targeted agents will revolutionize the way che- therapy is given, either alone or in conjunction with radiotherapy. Lastly, focused attention to patients' well-being has emphasized all measures of quality of life, has encouraged greater participation by patients and their caregivers in the decision-making process, and has encouraged the development of a variety of quality-of-life measurement tools to ensure that adverse effects of treatment are recognized and addressed.
Epidemiology of Brain Tumors.- Neuropathology and Molecular Biology of Intracranial Tumors.- Radiology of Brain Tumors: Structure and Physiology.- Surgically Curable Brain Tumors of Adults.- Low-Grade Gliomas: Evidence-Based Treatment Options.- Surgical Strategies for High-Grade Gliomas.- Radiation Oncology for Tumors of the Central Nervous System: Improving the Therapeutic Index.- Cytotoxic Chemotherapy for Diffuse Gliomas.- Innovative Treatment Strategies for High-Grade Gliomas.- Pituitary Tumors in Oncology.- Management of Lung Cancer, Breast Cancer, and Melanoma Metastatic to the Brain.- Neoplastic Meningitis.- Lymphoma Affecting the Central Nervous System.- Tumors of the Extradural Spine.- Tumors of the Spinal Cord and Intradural Space.- Symptom Management for Patients with Brain Tumors: Improving Quality of Life.
Erscheint lt. Verlag | 10.5.2007 |
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Reihe/Serie | MD Anderson Cancer Care Series | MD Anderson Cancer Care Series |
Vorwort | R. Sawaya, W.K.A. Yung |
Zusatzinfo | XII, 364 p. 87 illus. |
Verlagsort | New York |
Sprache | englisch |
Themenwelt | Medizin / Pharmazie ► Allgemeines / Lexika |
Medizin / Pharmazie ► Medizinische Fachgebiete ► Chirurgie | |
Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie | |
Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie | |
Schlagworte | brain • Glioma • low-grade glioma • moleculargenetics • nervous system • Neuropathology • neurosurgery • spine • Surgery • surgical oncology • Tumors |
ISBN-10 | 0-387-29202-0 / 0387292020 |
ISBN-13 | 978-0-387-29202-1 / 9780387292021 |
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