Induction Chemotherapy (eBook)

Prof. Dr. med. Karl Reinhard Aigner is Medical Director of the Department of Surgical Oncology in Medias Klinikum Burghausen, Bavaria. He had his surgical training in cardiovascular surgery at Friedrich-Alexander University in Erlangen. At Justus-Liebig University Giessen he specialized in surgical oncology, focusing on vascular techniques of drug delivery such as Implantofix and Jet Port catheters, and in 1981 first performed a technique of isolated perfusion of the liver with heart-lung machine in man. Furtheron he developed various techniques of segmental vascular isolation of body segments and organs, and the stopflow technique with adequately designed catheters. In 1982, together with Prof. Stephens from Sydney, he initiated the biannual International Congress of Regional Cancer Treatment (ICRCT) and from 1987 to 1991 was president of the International Society for Regional Cancer Therapy. From 1985 to 1998 he was managing editor of the International Journal Regional Cancer Treatment. He is author of numerous publications and book chapters, lectured and performed teaching operations on vascular perfusion techniques and oncological surgery in Europe the United States and Asia.Frederick Oscar Stephens (MD, MS FRCS (Ed), FACS, FRACS) is former Professor of Surgical Oncology and Head of Department of Surgery, The University of Sydney, Australia. With other colleagues in Europe, UK, North America, South Africa, India, Japan and Tawain he has been a pioneer in the development of the principles of using integrated treatment modalities in management of locally advanced cancers. Advanced malignancies in limbs that previously required limb amputation can now be treated equally effectively without amputation in about 80% of patients. Oncologists in many cancer clinics worldwide are now achieving similarly improved results from the application of similar techniques and principles. He was the founding president of The International Society for Regional Cancer Therapy (1982) and has lectured extensively on regional cancer treatment and surgical oncology in Germany, Austria, France, England, Scotland, Wales, Ireland, America, Canada, Israel, Greece, Hungary, Japan and New Zealand as well as in his home country of Australia. He is the author of over 200 publications in medical journals, several book Chapters and two theses. Since retirement he has authored 4 books on cancers in general and specific cancers for lay people, and with Professor Aigner and other world experts has written The Basics of Oncology, a text for medical and paramedical practitioners and nurse oncologists. A little known international surgical contribution of Professor Stephens is that when he was a Senior Surgical Registrar in training in Aberdeen Scotland with Professor Hugh Dudley, he published the first paper on Outpatient Surgery under general anaesthesia in adults in Lancet 1961. Outpatient (Day Stay or Ambulatory Surgery) techniques and policy have now become standard practice worldwide making great savings in health budgets the world over.

Introduction: Overview, History, Terminology and Early Clinical Experience.-The Principle of Dose-Response in Antineoplastic Drug Delivery.- Drug Removal Systems and Induction Chemotherapy.- Cryotherapy.- Local and Regional Hyperthermia.- The Role of Hypoxia and Hyperthermia in Chemotherapy.- Induction Chemotherapy in Head and Neck Cancers.- Isolated Thoracic Perfusion with Carotid Artery Infusion for Advanced and Chemoresistant Tumors of the Parotid Gland.- Induction Systemic Chemotherapy for Breast Cancer.- Induction Intra-arterial Chemotherapy (IAC) with Epirubicin and Mitoxantrone in Locally Advanced Breast Cancer.-Induction Bidirectional Chemotherapy for Gastric Cancer with Peritoneal Dissemination.- Gastric Cancer.- Oesophageal Cancer.- Regional Chemotherapy for Recurrent Platin Refractory Ovarian Cancer.- Penile Cancer Treated by Intra-aortic Infusion Chemotherapy.- Isolated Limb Perfusion for Melanoma.- Interventional Radiological Procedures for Port-Catheter Implantation.- Induction Chemotherapy for Hepatocellular Carcinoma.- Systemic Induction Chemotherapy for Advanced Stage Epithelial Ovarian Cancer.- Induction Chemotherapy for Cervical Cancer.- Induction Treatment in Sarcomas.- Induction Chemotherapy in Treatment of Sarcomas.- Liver Metastases.-Isolated Thoracic Perfusion with Chemofiltration (ITP-F) for Advanced and Pre-treated Non-Small-Cell Lung Cancer.-Isolation Perfusion Systems: Lungs.- Metastatic Cancers in Lung: Isolated Lung Perfusion – Clinical Studies.- Systemic and Regional Chemotherapy for Advanced and Metastasized Pancreatic Cancer.- Conclusion.