Advances in Clinical Chemistry (eBook)

Front Cover 1
Advances In Clinical Chemistry 4
Copyright 5
Contents 6
Contributors 10
Preface 12
Chapter 1: Amyloidosis 14
1. Abstract 15
2. Historical Perspective 15
3. Pathogenesis 16
4. Diagnosis 27
5. Classification, Clinical Presentation, and Prognosis of Amyloidosis 33
6. Treatment 41
References 49
Chapter 2: Urinary Markers in Colorectal Cancer 58
1. Abstract 58
2. Introduction 59
3. Potential Urinary Markers for Colorectal Cancer 60
4. Analytical Techniques and Data Analysis 63
5. Conclusions 66
References 66
Chapter 3: Effect of Hormone Replacement Therapy on Inflammatory Biomarkers 72
1. Abstract 73
2. Introduction 73
3. Inflammation and Vascular Disease 75
4. Mechanisms of Action of HRT in Vascular Biology 78
5. Effects of HRT on Inflammatory Markers 84
6. Conclusion 95
References 96
Chapter 4: Personalized Clinical Laboratory Diagnostics 108
1. Abstract 109
2. Introduction 109
3. Basic Concepts of Personalized Medicine 109
4. Molecular Diagnostic Technologies for Personalized Medicine 112
5. Role of PCR in Development of Personalized Medicine 112
6. Combined PCR-Enzyme-Linked Immunosorbent Assay (ELISA) 115
7. Non-PCR Methods 116
8. Direct Molecular Analysis Without Amplification 116
9. SNP and Personalized Medicine 116
10. Genetic Variations in the Human Genome Other Than SNPs 118
11. Role of Biomarkers in Personalized Medicine 121
12. Application of Biochip Technology in Developing Personalized Medicine 122
13. Role of Nanobiotechnology-Based Diagnostics in Personalized Medicine 124
14. Role of Cytogenetics in Personalized Medicine 127
15. Integration of Molecular Diagnostics and Therapeutics 129
16. Concluding Remarks and Future Prospects 130
. 131
References 131
Chapter 5: Verification Of Method Performance For Clinical Laboratories 133
1. Abstract 133
2. Introduction 135
3. ISO Quality Management System: The Fundamentals of Quality 136
4. Laboratory Quality Standards in Regulations and Accreditation Guidelines 142
5. Comparison of Quality Requirements 144
6. Performing Method Verification 145
7. Summary 149
References 149
Chapter 6: Interpreting the Proteome and Peptidome in Transplantation 152
1. Abstract 153
2. Introduction 153
3. Application of Proteomics and Peptidomics in Transplantation 168
4. Important Issues 173
5. Conclusion 175
References 176
Chapter 7: Biomarkers in Long-Term Vegetarian Diets 184
1. Introduction 185
2. Possible Nutritional Deficiencies in Association with Long-Term Vegetarian Diets 186
3. Biomarkers of Oxidant/Antioxidant Balance in Association with Vegetarian Diets 199
4. Biomarkers that Reflect Lower Risk of Disease in Long-Term Vegetarians 207
5. Biomarkers to Differentiate the Vegetarian from the Nonvegetarian 220
6. Summary and Recommendations for Clinical Chemistry 222
References 223
Chapter 8: Effect of Caloric Restriction on Oxidative Markers 236
1. Abstract 237
2. Introduction 237
3. Foods and ROS Generation 238
4. Mitochondria as a Source of Reactive Oxygen and Nitrogen Species 239
5. Caloric Restriction and Oxidative Stress 242
6. Oxidative Stress Markers by Caloric Restriction 245
7. Data Interpretation 253
8. Conclusions 254
References 255
Index 262
Colorplate 274