Autoimmune Diseases (eBook)

front cover 1
copyright 5
table of contents 6
front matter 11
Editorial Advisory Board 11
Contributors 12
Reviewers 16
Acknowledgments 18
Prospectus: The Road to Autoimmune Disease 20
body 28
Section I Immunologic Basis of Autoimmunity 28
1: Autoimmunity: A History of the Early Struggle for Recognition 30
2: Structural and Functional Aspects of the Innate and Adaptive Systems of Immunity 38
3: General Features of Autoimmune Disease 52
4: Antigen Presentation, Dendritic Cells, and Autoimmunity 64
5: Major Histocompatibility Complex and Autoimmunity 74
6: T Cells and Autoimmunity 86
7: Role of Th1 and Th2 Cells in Autoimmunity 110
8: Tolerance and Autoimmunity: T Cells 130
9: Regulatory T Cells 146
10: Peptide-Based Instruction of Suppressor Commitment in Naïve T Cells 160
11: B Cells and Autoimmunity 166
12: Memory B-Cell Development 184
13: Tolerance and Autoimmunity: B Cells 194
14: Generation of T-cell Antigenic Determinants in Autoimmunity and Their Recognition 206
15: Apoptotic Cells as a Source of Autoantigens 220
16: Effector Mechanisms of Autoimmunity: Antibodies and Immune Complexes 230
17: Functional Effects of Autoantibodies 244
18: Adhesion Molecules and Chemoattractants in the Pathogenesis and Treatment of Autoimmune Diseases 264
19: Signaling Pathways in T and B Lymphocytes 276
20: Genetics and Autoimmunity: HLA and MHC Genes 288
21: Genetics and Autoimmunity: Non-MHC Genes 300
22: Infections, Immunity, and Autoimmunity 316
23: Noninfectious Environmental Agents and Autoimmunity 324
24: Vaccines and Autoimmunity 336
25: Sex, Pregnancy, and Autoimmunity 344
26: Animal Models of Autoimmune Disease 356
Section II Autoimmune Diseases - Multisystem Diseases 376
71: Cameos 1022
70: Apoptosis and Autoimmunity: Lymphoproliferative Syndromes 1014
69: Lymphoma and Autoimmune Disease 998
68: Paraneoplastic Neurologic Diseases: Autoimmune Responses to Tumor Antigens 984
67: Idiopathic Bronchiolitis Obliterans, Idiopathic Pulmonary Fibrosis, and Autoimmune Disorders of the Lung 962
66: Large and Medium Vessel Vasculitides 948
65: Necrotizing Arteritis and Small Vessel Vasculitis 926
64: Atherosclerosis: Autoimmunity to Heat-Shock Proteins 916
63: Myocarditis and Dilated Cardiomyopathy 902
62: Rheumatic Heart Disease 890
61: Oophoritis 876
60: Orchitis and Male Infertility 868
59: Kidney Disease: Goodpasture’s Disease, Lupus Nephritis, ANCA-Associated Glomerulonephritis 848
58: Non-Bullous Skin Diseases: Alopecia, Vitiligo Psoriasis, and Urticaria 834
57: Bullous Skin Diseases: Pemphigus Pemphigoid 816
56: Pancreatitis 806
55: Primary Sclerosing Cholangitis 794
54: Primary Biliary Cirrhosis 776
53: Chronic Hepatitis 756
52: Inflammatory Bowel Diseases: Ulcerative Colitis and Crohn’s Disease 740
51: Celiac Disease 720
50: Inner Ear Disease 708
49: Ocular Disease 696
48: Myasthenia Gravis and other Antibody-Associated Neurological Diseases 680
47: Peripheral Neuropathy 660
46: Multiple Sclerosis 642
45: Clotting Disorders 628
44: Aplastic Anemia 618
43: Neutropenia 612
42: Thrombocytopenic Purpura 602
41: Hemolytic Anemia 584
40: Hypophysitis 574
39: Gastritis and Pernicious Anemia 554
38: Polyendocrine Syndromes 542
37: Adrenalitis 528
36: Type 1 Diabetes 510
35: Thyroid Disease 494
34: Polymyositis and Dermatomyositis 480
33: Spondyloarthritis and Chronic Idiopathic Arthropathies 464
32: Rheumatoid Arthritis 444
31: Sjögren Syndrome 428
30: Antiphospholipid Syndrome 408
29: Systemic Sclerosis, Scleroderma 396
28: Systemic Lupus Erythematosus: Immunologic Features 384
27: Systemic Lupus Erythematosus and Related Diseases: Clinical Features 378
Section III Diagnosis, Prevention, and Therapy 1036
72: Autoantibody Assays, Testing, and Standardization 1038
73: T Cell Assays 1050
74: Prediction of Autoimmune Disease 1058
75: Prevention of Autoimmune Disease: Type 1 Diabetes as a Paradigm 1072
76: Emerging Therapies for Autoimmune Diseases 1090
Section IV Epilogue 1110
77: Advocatus Diaboli: What is not known about Autoimmune Disease 1112
index 1122