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Arsenic Exposure and Health Effects IV (eBook)

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2001 | 1. Auflage
492 Seiten
Elsevier Science (Verlag)
978-0-08-052305-7 (ISBN)
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167,69 inkl. MwSt
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This collected volume of authoritative articles represents the state-of-the-art in arsenic research. Arsenic experts from around the world, participants in the Fourth International Conference on Arsenic Exposure and Health Effects organized by the Society of Environmental Geochemistry and Health in 2000, present their critical findings.



A vital contribution to arsenic study and policy making, this volume examines the global impact of the toxin and discusses arsenic in the environment, mechanisms of arsenic metabolism and carcinogenesis, water treatment technology, and medical care. Arsenic Exposure and Health Effects offers informed, challenging insights into a highly important and controversial topic.


This collected volume of authoritative articles represents the state-of-the-art in arsenic research. Arsenic experts from around the world, participants in the Fourth International Conference on Arsenic Exposure and Health Effects organized by the Society of Environmental Geochemistry and Health in 2000, present their critical findings.A vital contribution to arsenic study and policy making, this volume examines the global impact of the toxin and discusses arsenic in the environment, mechanisms of arsenic metabolism and carcinogenesis, water treatment technology, and medical care. Arsenic Exposure and Health Effects offers informed, challenging insights into a highly important and controversial topic.

Cover 1
Title Page 2
Copyright Page 5
Contents 8
Preface 6
List of Contributors 12
Obituary: Kurt J. Irgolic 1938–1999 22
PART I: OCCURRENCE AND EXPOSURE 26
Chapter 1. Arsenic: the ‘King of Poisons’ in Antiquity – a Possible Threat to Future Sustainability 26
Chapter 2. International Perspective on Naturally Occurring Arsenic Problems in Groundwater 34
Chapter 3. Characterization of Arsenic-bearing Sediments in the Gangetic Delta of West Bengal, India 52
Chapter 4. Geochemical and Palaeohydrological Controls on Pollution of Groundwater by Arsenic 78
Chapter 5. Progresses on Researches of Endemic Arsenism in China: Population at Risk, Intervention Actions, and Related Scientific Issues 104
Chapter 6. Arsenic in Latin America: Occurrence, Exposure, Health Effects and Remediation 112
Chapter 7. Impacts of Historic Arsenical Pesticide Use on Residential Soils in Denver, Colorado 122
Chapter 8. Arsenic Speciation in Fresh-Water Fish and Bivalves 140
Chapter 9. Determination of Organoarsenic Compounds in Finishing Chicken Feed and Chicken Litter by HPLC–ICP–MS 150
PART II: HEALTH EFFECTS EPIDEMIOLOGY 160
Chapter 10. Individual Susceptibility to Arseniasis 160
Chapter 11. Bayesian Model Averaging with Applications to the Risk Assessment for Arsenic in Drinking Water 170
Chapter 12. Epidemiological Study on Various Non-carcinomatous Manifestations of Chronic Arsenic Toxicity in a District of West Bengal 178
Chapter 13. Possible Effects of Arsenic on Visual Perception and Visual–Motor Integration of Children in Thailand 190
Chapter 14. Interactions between Arsenic and Other Factors in Relation to Carcinogenicity 198
Chapter 15. Arsenic in Drinking Water from Groundwater in Transylvania, Romania: an Overview 206
Chapter 16. Preliminary Analysis of Lung Cancer Incidence in Arsenic Exposed Population 210
Chapter 17. Arsenic Ingestion and Health Effects in Bangladesh: Epidemiological Observations 218
Chapter 18. Occurrence of Cancer in Arsenic Contaminated Area, Ronpibool District, Nakorn Srithmmarat Province, Thailand 226
PART III: BIOMARKERS 232
Chapter 19. Arsenic Exposure, Null Genotypes of Glutathione S-Transferase M1, T1 and P1, and Risk of Carotid Atherosclerosis among Residents in the Lanyang Basin of Taiwan 232
Chapter 20. Chronic Inorganic Arsenic Exposure Alters Heme Metabolism in Humans 246
Chapter 21. Mutations in C57Bl/6J and Metallothionein Knock-out Mice Induced by Chronic Exposure of Sodium Arsenate in Drinking Water 256
PART IV: MECHANISMS 268
Chapter 22. Arsenite Exposure Causes both Hypomethylation and Hypermethylation in Human Cell Lines in Culture at Low Concentrations 268
Chapter 23. Induction of Proliferative Lesions of the Uterus, Testes and Liver in Swiss Mice Given Repeated Injections of Sodium Arsenate 280
Chapter 24. Sub-Toxic Arsenite Induces a Multi-Component Protective Response against Oxidative Stress in Human Cells 290
Chapter 25. The Carcinogenicity of Dimethylarsinic Acid (DMA) in Rats 302
Chapter 26. Human Cell Models for Arsenic Carcinogenicity and Toxicity: Transformation and Genetic Susceptibility 310
Chapter 27. Research Requirements for a Biologically Realistic Cancer Risk Assessment for Arsenic 322
PART V: METABOLISM 330
Chapter 28. The Discovery, Importance and Significance of Monomethylarsonous Acid (MMAIII) in Urine ofHumans Exposed to Inorganic Arsenic 330
Chapter 29. The Impact of Selenium Status on the Metabolism and Disposition of Arsenic and its Implications for Epidemiologic Investigations 340
Chapter 30. Trivalent Methylated Arsenicals: Toxic Products of the Metabolism of Inorganic Arsenic 350
Chapter 31. Speciation of Human Urinary Arsenic Including the Trivalent Methylation Metabolites 364
Chapter 32. Dose–Response Relationships for the Metabolism and Urinary Excretion of Arsenicals in Humans 378
Chapter 33. Arsenic Methylation and the S-Adenosylmethionine-Mediated Transmethylation/ Transsulfuration Pathway 392
PART VI: INTERVENTION ANDMEDICAL TREATMENT 406
Chapter 34. An Overview of the UNICEF Supported Arsenic Mitigation Programme in Bangladesh 406
Chapter 35. Seventeen Years Experience of Arsenicosis inWest Bengal, India 412
Chapter 36. Arsenic Mobilization by DMPS 422
Chapter 37. Arsenic Mitigation and Water Supply in Bangladesh 432
Chapter 38. Community-Based Management of Arsenic-Affected Patients 438
Chapter 39. A Comprehensive Review of Low-Cost, Tubewell Water Treatment Technologies for ArsenicRemoval 444
Chapter 40. Surface Properties of an Advanced Adsorbent Developed for Arsenic Removal from Drinking Water 456
Chapter 41. Critical Evaluation of a Simple Arsenic Removal Method for Groundwater Bangladesh 466
Chapter 42. Innovative Technologies for Remediation of Arsenic in Soil and Groundwater 478
Author Index 488
Keyword Index 490

Erscheint lt. Verlag 27.11.2001
Sprache englisch
Themenwelt Studium 2. Studienabschnitt (Klinik) Pharmakologie / Toxikologie
Studium Querschnittsbereiche Prävention / Gesundheitsförderung
Technik Umwelttechnik / Biotechnologie
Wirtschaft
ISBN-10 0-08-052305-6 / 0080523056
ISBN-13 978-0-08-052305-7 / 9780080523057
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