Advances in Clinical Chemistry (eBook)

Front Cover 1
Advances in Clinical Chemistry 4
Copyright Page 5
Contents 6
Contributors 10
Preface 12
Chapter 1: Heat-shock proteins in cardiovascular disease 14
Abbrevations 14
1. Abstract 16
2. Introduction 16
3. Atherogenesis and Possible Stimuli of Inducible HSPs 17
4. HSPs/Anti-HSPs as Biomarkers of Atherothrombosis 21
5. Molecular Mechanisms: Bystanders or Actors? 28
6. HSP as Therapeutic Targets in CVD/Atherothrombosis 38
7. Conclusions 41
Acknowledgments 41
References 42
Chapter 2: Polyamines in cancer 58
Abbrevations 58
1. Abstract 59
2. Introduction 59
3. Overview of Polyamine Regulation 60
4. Deregulation of Polyamines in Cancer 63
5. Genetic Variability in ODC Affecting Carcinogenesis 67
6. EIF5A and Cancer 69
7. Chemoprevention Strategies Within Polyamine Pathway 73
Acknowledgments 76
References 76
Chapter 3: Acquired hemophilia A 84
1. Abstract 84
2. Introduction 85
3. Pathogenesis 85
4. Laboratory Diagnosis 86
5. Conclusions 91
Acknowledgments 92
References 92
Chapter 4: Hypobetalipoproteinemia: Genetics, biochemistry, and clinical spectrum 94
Abbrevations 95
1. Abstract 95
2. Introduction 96
3. Pathways of apoB-Containing Lipoproteins Production 96
4. Dominant Forms of Primary HBL 100
5. Recessive Forms of Primary HBL 104
6. Primary Orphan FHBL 105
7. Spectrum of Clinical Manifestations in Primary HBL 105
8. Main Clinical Issues of FHBL 107
9. Secondary Hypobetalipoproteinemias 109
10. Conclusions 110
Addendum 112
Acknowledgment 114
References 114
Chapter 5: Sm peptides in differentiation of autoimmune diseases 122
1. Abstract 122
2. Introduction 123
3. Systemic Lupus Erythematosus 123
4. Mixed Connective Tissue Disease 125
5. Biochemical Aspects of the Sm Antigen 125
6. Characteristics of Anti-Sm Antibodies 126
7. Detection of Anti-Sm Antibodies 127
8. Clinical Association of Anti-Sm Antibodies 131
9. Meta-Analysis of Anti-Sm Antibodies 131
10. Genesis of Anti-Sm Antibodies 132
11. (Sm) Peptides as Antigens 132
12. Summary and Conclusion 135
13. Take Home Messages 135
References 135
Chapter 6: Aromatase activity and bone loss 142
1. Abstract 142
2. Introduction 143
3. Aromatase and Sources of Estrogen Production 144
4. The Aromatase Gene and Its Tissue-Specific Regulation 146
5. Aromatase Deficiency and the Bone 147
6. Skeletal Consequences of Aromatase Excess 158
7. Threshold Estradiol Hypothesis for Skeletal Sufficiency 159
8. Variability in the Level of Aromatase Activity: Effects on Bone Metabolism 161
9. Summary and Conclusions 166
References 167
Chapter 7: Biochemistry of adolescent idiopathic scoliosis 178
1. Abstract 179
2. Introduction 179
3. Bone Biochemical Parameters 181
4. Hormones 181
5. Trace Elements 184
6. Hematological Parameters-Platelets 184
7. Melatonin 185
8. Conclusions 191
References 192
Index 196