Peptide Nucleic Acids, Morpholinos and Related Antisense Biomolecules (eBook)

EDITORS 10
CONTRIBUTORS 10
PREFACE 15
Part I Research Applications 17
The Many Faces of PNA 18
Modulation of Nucleic Acid Information Processing by PNAs: Potential Use in Anti-Viral Therapeutics 33
Targeted Gene Delivery: The Role of Peptide Nucleic Acid 45
Imaging Gene Expression in the Brain with Peptide Nucleic Acid ( PNA) Antisense Radiopharmaceuticals and Drug Targeting Technology 53
Receptor- Specific Targeting with Complementary Peptide Nucleic Acids Conjugated to Peptide Analogs and Radionuclides 76
Morpholinos and PNAs Compared 104
Chemistiy of Locked Nucleic Acids (LNA): Design, Synthesis and Bio-Physical Properties 129
Recent Applications of RNA Interference ( RNAi) in Mammalian Systems 148
Part II Clinical Applications 163
Peptide Nucleic Acids as Epigenetic Inhibitors ofHIV- 1 164
Therapeutic Uses of Peptide Nucleic Acids ( PNA) in Oncology 184
PNAs as Novel Cancer Therapeutics 194
Medicinal Chemistry of Plasmid DNA with Peptide Nucleic Acids: A New Strategy for Gene Therapy 208
Locked Nucleic Acids (LNA) and Medical Applications 225
Peptide Nucleic Acids as Agents to Modify Target Gene Expression and Function 236
Peptide Nucleic Acids: Cellular Delivery and Recognition of DNA and RNA Targets 249
The Use of PNAs and Their Derivatives in Mitochondrial Gene Therapy 256
Gene Silencing through RNA Interference: Potential for Therapeutics and Functional Genomics 265
Transcriptional Activation of Human CREB Gene Promoter Using Bis- PNA ( Peptide Nucleic Acid) 278
Index 283