Pediatric Inflammatory Bowel Disease (eBook)
XXXIV, 686 Seiten
Springer US (Verlag)
978-0-387-73481-1 (ISBN)
This textbook focuses on the pediatric aspects of Inflammatory Bowel Disease (IBD). It covers diagnostic approaches, special nutrition, growth, and bone density, as well as psychosocial considerations that are specific to the young and may thus not exist in adults. Chapters discuss the full range of topics from IBD genetics right through to nutritional and growth aspects and condition management. The book features many visual aids as well as endoscopy and surgery images.
Pediatric Inflammatory Bowel Diseases (IBD) are the most common and most significant chronic disorders in Pediatric Gastroenterology. The onset of Crohn disease and ulcerative colitis in the first two decades of life presents a number of diagnostic and therapeutic challenges that are unique to pediatric patients. Although the studies available for pediatric diagnosis have improved dramatically in the past three decades, the improvement in technology alone cannot account for the increased frequency of IBD recognized in early childhood. While therapy for older patients has improved dramatically with the use of immunomodulators and the development of exciting biologic strategies, rarely if ever have comprehensive studies of the pharmacokinetics, safety and efficacy of any of the IBD medications been performed in pediatric patients. A number of excellent medications are not available in liquid preparations that can be swallowed by children, and others, such as timed-release formulations, are developed for delivery to an adult gastrointestinal tract. It is unfortunate that the care we provide to children is often an extrapolation of what is known about and available for adults with IBD. Pediatric patients with IBD face a number of unique challenges. The onset of disease before puberty can be devastating. Growth failure is a particularly difficult problem with potentially permanent consequences. Much of the pediatric specific research has focused on the role of nutritional therapy to treat growth failure and induce remission.
Foreword 6
Preface 8
Contents 9
Contributors 20
Etiology and Pathogenesis 31
Genetics of Inflammatory Bowel Diseases 32
Gut Immunity and Inflammatory Bowel Disease 44
Cytokines and Inflammatory Bowel Disease 59
Epidemiology and Clinical Features 70
Epidemiology of Pediatric Inflammatory Bowel Disease 71
Early Onset Inflammatory Bowel Disease- Epidemiology and Clinical Features 87
The Natural History of Pediatric Crohn Disease 92
Natural History of Pediatric Ulcerative Colitis 100
Natural History of Pediatric Indeterminate Colitis 107
Extraintestinal Manifestations of Pediatric Inflammatory Bowel Disease 115
Growth Impairment in Pediatric Inflammatory Bowel Disease 126
Skeletal Health in Pediatric Inflammatory Bowel Disease 141
Puberty and Pediatric-Onset Inflammatory Bowel Disease 155
Classification of Pediatric Inflammatory Bowel Disease 165
Diagnosis 178
The History and Physical Exam in Pediatric Inflammatory Bowel Disease 179
Differential Diagnosis of Pediatric Inflammatory Bowel Disease 184
Laboratory Evaluation of Pediatric Inflammatory Bowel Disease 198
Radiologic Evaluation of Pediatric Inflammatory Bowel Disease 211
Endoscopic Modalities in Pediatric Inflammatory Bowel Disease 228
The Pathology of Chronic Inflammatory Bowel Disease 258
Video Capsule Endoscopy in Pediatric Inflammatory Bowel Disease 280
Bone Health Assessment in Pediatric Inflammatory Bowel Disease 291
Assessment of Growth and Nutritional Status in Pediatric Inflammatory Bowel Disease 311
Medical Therapy 323
Pharmacogenetics in Inflammatory Bowel Disease 324
5-Aminosalicylate Therapy 331
Antibiotic Therapy 343
Nutritional Therapy 351
Probiotic Therapy 365
Corticosteroid Therapy 376
6-Mercaptopurine Therapy 383
Methotrexate Therapy 391
Infliximab Therapy 399
Biologic Therapies 414
Treatment of Perianal Crohn Disease Fistulae 439
Treatment of Fulminant Colitis 457
Surgical Therapy 462
Surgical Management of Crohn’s Disease 463
Surgical Treatment of Ulcerative Colitis 477
Pouchitis After Ileal Pouch-Anal Anastomosis 492
Enteral Feeding Devices and Ostomies 502
Research 511
Clinical Indices for Pediatric Inflammatory Bowel Disease Research 512
Clinical Trials (Clinical Perspective) 536
Clinical Trials (Industry Perspective) 545
Special Considerations 556
Psychological Aspects of Pediatric Inflammatory Bowel Disease 557
Measurement of Quality of Life in Pediatric Inflammatory Bowel Disease 566
Irritable Bowel Syndrome and Functional Gastrointestinal Disorders in Pediatric Inflammatory Bowel Disease 582
Inflammatory Bowel Disease in Pregnancy 593
Malignant Tumors Arising in Inflammatory Bowel Disease 610
Quality Improvement in Inflammatory Bowel Disease 630
Advocacy for Pediatric Patients with Inflammatory Bowel Disease 639
Legislative Advocacy 653
Transition from Pediatric to Adult Care 658
Index 663
| Erscheint lt. Verlag | 24.11.2007 |
|---|---|
| Zusatzinfo | XXXIV, 686 p. 113 illus., 60 illus. in color. |
| Verlagsort | New York |
| Sprache | englisch |
| Themenwelt | Medizinische Fachgebiete ► Chirurgie ► Viszeralchirurgie |
| Medizinische Fachgebiete ► Innere Medizin ► Gastroenterologie | |
| Medizin / Pharmazie ► Medizinische Fachgebiete ► Pädiatrie | |
| Schlagworte | Bone Density • Endoscopy • Genetics • Nutrition • therapeutics |
| ISBN-10 | 0-387-73481-3 / 0387734813 |
| ISBN-13 | 978-0-387-73481-1 / 9780387734811 |
| Haben Sie eine Frage zum Produkt? |
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