Methods of Cancer Diagnosis, Therapy and Prognosis (eBook)

PART I GENERAL METHODS AND OVERVIEWS 1.1. METABOLIC TRANSFORMATIONS OF MALIGNANT CELLS (AN OVERVIEW) Leslie C. Costello and Renty B. Franklin INTRODUCTION
DEFINING A MALIGNANT CELL: A PARASITIC EXISTENCE
THE IN SITU ENVIRONMENT OF THE MALIGNANT CELL DICTATES ITS METABOLISM
TUMOR CELL PROLIFERATION: METABOLIC PATHWAYS FOR ITS ACHIEVEMENT
COUPLING OF GLYCOLYSIS VIA CITRATE TO DE NOVO LIPOGENESIS/CHOLESTEROGENESIS
OPERATION OF THE KREBS CYCLE IN TUMOR CELLS
GLUTAMINOLYSIS AS AN ALTERNATE OR ADDITIONAL PATHWAY IN TUMOR CELLS
OPERATION OF THE KREBS CYCLE IN TUMOR CELLS
APPLICATION OF MOLECULAR GENETICS AND PROTEOMICS TO TUMOR CELL INTERMEDIARY METABOLISM
ACKNOWLEDGEMENT
REFERENCES 1.2. IMAGING TO DETECT RECURRENT CANCER S.J. Gwyther INTRODUCTION
LUNG CANCER
BREAST CANCER
COLORECTAL CANCER
LYMPHOMAS
PANCREATIC CANCER
PROSTATE CANCER
GYNECOLOGICAL CANCERS
Ovarian Cancer
Endometrial Cancer
Cervical Cancer
HEAD AND NECK CANCERS
THYROID CANCER
RENAL AND BLADDER TUMORS
PRIMARY INTRACRANIAL TUMORS
CONCLUSIONS
REFERENCES 1.3. TUMOR GENE THERAPY: MAGNETIC RESONANCE IMAGING AND MAGNETIC RESONANCE SPECTROSCOPY Mikko I. Kettunen and Olli H.J. Grohn INTRODUCTION
TUMOR GENE THERAPY
MAGNETIC RESONANCE IMAGING
Endogenous Magnetic Resonance Imaging Contrast
Exogenous Contrast Agents
MAGNETIC RESONANCE SPECTROSCOPY
DETECTION OF TRANSGENE DELIVERY AND EXPRESSION USING
MAGNETIC RESONANCE IMAGING AND SPECTROSCOPY
DETECTION OF GENE THERAPY RESPONSE USING MAGNETIC RESONANCE IMAGING AND SPECTROSCOPY
Volumetric Imaging
Endogenous Contrasts
Sodium Magnetic Resonance Imaging
Molecular Imaging
Magnetic Resonance Spectroscopy of Metabolic Alterations
SUMMARY
REFERENCES 1.4. ASSESSMENT OF GENE TRANSFER: MAGNETIC RESONANCE IMAGING AND 18F-FLUORODEOXYGLUCOSE POSITRON EMISSION TOMOGRAPHY Annette Altman and Uwe Haberkorn INTRODUCTION
MOLECULAR IMAGING MODALITIES FOR GENE EXPRESSION
MOLECULAR IMAGING OF SUICIDE GENE TRANSFER AND THERAPEUTIC EFFECTS
MOLECULAR IMAGING SUBSTRATE UPTAKE AFTER SUICIDE GENE TRANSDUCTION
NONINVASIVE IMAGING OF REPORTER GENE TRANSFER
REFERENCES 1.5. ROLE OF MUTATIONS IN TP53 IN CANCER (AN OVERVIEW) Franck Toledo INTRODUCTION
IMPACT OF TP53 MUTATIONS ON P53 TRANSACTIVATION CAPACITY
OTHER EFFECTS OF TP53 MUTATIONS
TP53 MUTATIONS AND THE ETIOLOGY OF HUMAN CANCERS
PROGNOSTIC AND PREDICTIVE VALUE OF TP53 MUTATIONS
CORRECTION OF P53 PATHWAY IN TUMORS
FUTURE PERSPECTIVES
REFERENCES 1.6. PERSONALIZED CANCER MEDICINE (AN OVERVIEW) Sarah J. Welsh and Garth Powis INTRODUCTION
WHY IS PERSONALIZED MEDICINE IMPORTANT IN CANCER?
TO WHAT EXTENT IS CANCER MEDICINE ALREADY PERSONALIZED?
FUTURE OF PERSONALIZED MEDICINE IN CANCER
CHALLENGES FOR ACHIEVING PERSONALIZED MEDICINE
REFERENCES 1.7. RADIATION DOSES TO PATIENTS USING COMPUTED RADIOGRAPHY, DIRECT DIGITAL RADIOGRAPHY, AND SCREEN-FILM RADIOGRAPHY Gaetano Compagnone INTRODUCTION
RADIATION QUANTITIES USED IN PATIENT DOSIMETRY
CONVENTIONAL SCREEN-FILM SYSTEMS
PATIENT DOSE AND IMAGE QUALITY WITH CONVENTIONAL SCREEN-FILM SYSTEMS
COMPUTED RADIOGRAPHY
PATIENT DOSE AND IMAGE QUALITY WITH COMPUTED RADIOGRAPHY
DIRECT DIGITAL RADIOGRAPHY
PATIENT DOSE AND QUALITY WITH DIRECT DIGITAL RADIOGRAPHY
CONCLUSIONS
REFERENCES 1.8. CANCER VACCINES AND IMMUNE MONITORING (AN OVERVIEW) Zsuzsanna Tabi and Stephen Man INTRODUCTION
PROPHYLACTIC CANCER VACCINES
Vaccines