Principles of Diabetes Mellitus (eBook)

Leonid Poretsky (Herausgeber)

eBook Download: PDF
2010 | 2nd ed. 2010
XVI, 852 Seiten
Springer US (Verlag)
978-0-387-09841-8 (ISBN)

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'Principles of Diabetes Mellitus, Second Edition' is an important update to the comprehensive textbook first published in 2002 and reissued in 2004. It is written for physicians of all specialties who, on a daily basis, deal with an illness which has reached epidemic proportions. The book is also intended for medical students and investigators of all aspects of diabetes.

The last five years have witnessed major developments in our understanding of diabetes and in therapeutic approaches to this disease. Thus, in addition to updating all chapters, the authors added eight new chapters to the second edition. 'Principles of Diabetes Mellitus, Second Edition' covers diabetes in all of its aspects - genetics, epidemiology, pathophysiology, clinical manifestations, therapy and prevention.



Leonid Poretsky, Chief, Division of Endocrinology and Metabolism, Beth Israel Medical Center, New York. NY. His experience and excellent cadre of chapter authors will offer an authoritative review of diabetes.


"e;Principles of Diabetes Mellitus, Second Edition"e; is an important update to the comprehensive textbook first published in 2002 and reissued in 2004. It is written for physicians of all specialties who, on a daily basis, deal with an illness which has reached epidemic proportions. The book is also intended for medical students and investigators of all aspects of diabetes.The last five years have witnessed major developments in our understanding of diabetes and in therapeutic approaches to this disease. Thus, in addition to updating all chapters, the authors added eight new chapters to the second edition. "e;Principles of Diabetes Mellitus, Second Edition"e; covers diabetes in all of its aspects - genetics, epidemiology, pathophysiology, clinical manifestations, therapy and prevention.

Leonid Poretsky, Chief, Division of Endocrinology and Metabolism, Beth Israel Medical Center, New York. NY. His experience and excellent cadre of chapter authors will offer an authoritative review of diabetes.

Preface to the Second Edition 5
Preface to the First Edition 6
Contents 7
Contributors 11
Part I 17
The Main Events in the History of Diabetes Mellitus 18
Part II Physiology of Glucose Metabolism 32
Normal Glucose Homeostasis 33
Endocrine Pancreas 50
The Role of Incretins in Insulin Secretion 69
Cellular Mechanisms of Insulin Action 87
The Role of Brain in Glucose Metabolism 100
Part III Diagnosis and Epidemiology of Diabetes 116
Diagnostic Criteria and Classification of Diabetes 117
Epidemiology 126
Diabetes in Culturally Diverse Populations: From Biology to Culture 137
Part IV Genes and Diabetes 153
Genetics of Type 2 Diabetes: From Candidate Genes to Genome- Wide Association Analysis 154
Rodent Models of Diabetes 171
Part V Diabetes Syndromes 185
Type 1 Diabetes Mellitus: Epidemiology, Genetics, Pathogenesis, and Clinical Manifestations 186
Type 2 Diabetes Mellitus: Epidemiology, Genetics, Pathogenesis, and Clinical Manifestations 207
Maturity-Onset Diabetes of the Young: Molecular Genetics, Clinical Manifestations, and Therapy 225
Diabetes in Pregnancy 237
Secondary Causes of Diabetes Mellitus 249
Syndromes of Extreme Insulin Resistance 263
Part VI Complications of Diabetes 282
Acute Hyperglycemic Syndromes: Diabetic Ketoacidosis and the Hyperosmolar State 283
Hypoglycemia in Diabetes Mellitus 298
Intake of Advanced Glycation Endproducts: Role in the Development of Diabetic Complications 314
Diabetic Retinopathy 332
Diabetic Nephropathy 348
Diabetic Neuropathy 357
Peripheral Vascular Disease in Diabetes 371
The Diabetic Foot 380
Male Sexual Dysfunction in Diabetes Mellitus 399
Gastrointestinal Manifestations of Diabetes 416
Dyslipidemia: Pathogenesis and Management 432
Dermatological Complications of Diabetes Mellitus Allergy to Insulin and Oral Agents
Part VII Related Disorders 469
Obesity - Genetics, Pathogenesis, Therapy 470
Hypertension 484
Coronary Artery Disease and Cardiomyopathy 494
Polycystic Ovary Syndrome 509
Insulin Resistance and the Metabolic Syndrome 525
Diabetes and Liver Disease 550
The Increased Risk of Cancer in Obesity and Type 2 Diabetes: Potential Mechanisms 571
Diabetes and Sleep Disorders 592
HIV Infection and Diabetes 607
Part VIII Therapy of Diabetes Mellitus - General Principles 633
Glycemic Goals 634
Behavioral and Educational Approaches to Diabetes Self- Management 648
Dietary Therapy of Diabetes Mellitus 665
Exercise in the Therapy of Diabetes Mellitus 675
Therapy of Type 1 Diabetes Mellitus 697
Treating Type 2 Diabetes Mellitus 718
Prevention of Microvascular Complications of Diabetes - General Overview 735
Psychiatric Care of the Patient with Diabetes 740
Management of Diabetes and Hyperglycemia in the Hospital Setting 757
The Future of Diabetes Therapy 771
Part IX Diabetes Prevention 785
Prevention of Type 1 Diabetes Mellitus 786
Prevention of Type 2 Diabetes Mellitus 804
Part X 816
Resources for Patients with Diabetes 817
Subject Index 827

Erscheint lt. Verlag 24.1.2010
Zusatzinfo XVI, 852 p. 185 illus., 65 illus. in color.
Verlagsort New York
Sprache englisch
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Allgemeinmedizin
Medizinische Fachgebiete Innere Medizin Diabetologie
Medizinische Fachgebiete Innere Medizin Kardiologie / Angiologie
Medizin / Pharmazie Medizinische Fachgebiete Intensivmedizin
Medizin / Pharmazie Pflege
Schlagworte Diabetes • Diabetes mellitus • homeostasis • Hypertension • Insulin • Insulin Secretion • pancreas
ISBN-10 0-387-09841-0 / 0387098410
ISBN-13 978-0-387-09841-8 / 9780387098418
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