Tumor Ablation (eBook)

Principles and Practice
eBook Download: PDF
2008 | 2005
XXIV, 542 Seiten
Springer New York (Verlag)
978-0-387-28674-7 (ISBN)

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There is an enormous sense of excitement in the communities of cancer research and cancer care as we move into the middle third of the ?rst decade of the 21st century. For the ?rst time,there is a true sense of c- ?dence that the tools provided by the human genome project will enable cancer researchers to crack the code of genomic abnormalities that allow tumor cells to live within the body and provide highly speci?c, virtually non-toxic therapies for the eradication,or at least ?rm control of human cancers. There is also good reason to hope that these same lines of inquiry will yield better tests for screening, early detection, and prev- tion of progression beyond curability. While these developments provide a legitimate basis for much op- mism, many patients will continue to develop cancers and suffer from their debilitating effects, even as research moves ahead. For these in- viduals, it is imperative that the cancer ?eld make the best possible use of the tools available to provide present day cancer patients with the best chances for cure, effective palliation, or, at the very least, relief from symptoms caused by acute intercurrent complications of cancer. A modality that has emerged as a very useful approach to at least some of these goals is tumor ablation by the use of physical or physiochemical approaches.
There is an enormous sense of excitement in the communities of cancer research and cancer care as we move into the middle third of the ?rst decade of the 21st century. For the ?rst time,there is a true sense of c- ?dence that the tools provided by the human genome project will enable cancer researchers to crack the code of genomic abnormalities that allow tumor cells to live within the body and provide highly speci?c, virtually non-toxic therapies for the eradication,or at least ?rm control of human cancers. There is also good reason to hope that these same lines of inquiry will yield better tests for screening, early detection, and prev- tion of progression beyond curability. While these developments provide a legitimate basis for much op- mism, many patients will continue to develop cancers and suffer from their debilitating effects, even as research moves ahead. For these in- viduals, it is imperative that the cancer ?eld make the best possible use of the tools available to provide present day cancer patients with the best chances for cure, effective palliation, or, at the very least, relief from symptoms caused by acute intercurrent complications of cancer. A modality that has emerged as a very useful approach to at least some of these goals is tumor ablation by the use of physical or physiochemical approaches.

Foreword I 5
Foreword II 7
Foreword III 8
Preface 10
Contents 12
Contributors 16
Introduction to Ablation 24
History of Ablation 25
Epidemiology: How to Appraise the Ablation Literature Critically 39
Image-Guided Tumor Ablation: Basic Science 45
Tumor Angiogenesis: General Principles and Therapeutic Approaches 63
Operations for Tumor Ablation 78
Image- Guided Tumor Ablation: How to Build a Practice 79
Anesthesia for Ablation 84
Devices, Equipment, and Operation of Ablation Systems 96
Imaging for Tumor Ablation 113
Intraoperative Ultrasound- Guided Procedures 114
Computed Tomography Imaging for Tumor Ablation 123
Positron Emission Tomography Imaging for Tumor Ablation 140
Ultrasound Imaging in Tumor Ablation 154
Magnetic Resonance Imaging Guidance for Tumor Ablation 167
Magnetic Resonance Imaging Guidance of Radiofrequency Thermal Ablation for Cancer Treatment 186
Image Guidance and Control of Thermal Ablation 201
Methods of Ablation 211
Percutaneous Ethanol Injection Therapy 212
Radiofrequency Ablation 222
Microwave Coagulation Therapy for Liver Tumors 235
Microwave Ablation: Surgical Perspective 245
Percutaneous Laser Therapy of Primary and Secondary Liver Tumors and Soft Tissue Lesions: Technical Concepts, Limitations, Results, and Indications 251
Cryoablation: History, Mechanism of Action, and Guidance Modalities 267
Combined Regional Chemoembolization and Ablative Therapy for Hepatic Malignancies 283
Focused Ultrasound for Tumor Ablation 290
New Technologies in Tumor Ablation 302
Combination Therapy for Ablation 318
Organ System Tumor Ablation 325
Ablation of Liver Metastases 326
Ablation for Hepatocellular Carcinoma 337
Radiofrequency Ablation of Neuroendocrine Metastases 347
Tumor Ablation in the Kidney 356
Radiofrequency Ablation for Thoracic Neoplasms 368
Soft Tissue Ablation 384
Image- Guided Palliation of Painful Skeletal Metastases 392
Radiofrequency Ablation of Osteoid Osteoma 404
Image- Guided Prostate Cryotherapy 417
Uterine Artery Embolization for Fibroid Disease 427
Applications of Cryoablation in the Breast 437
Percutaneous Ablation of Breast Tumors 443
Complications of Tumor Ablation 455
Perspectives 471
Tumor Ablation for Patients with Lung Cancer: The Thoracic Oncologist's Perspective 472
Ablative Therapies for Gastrointestinal Malignancies: The Gastrointestinal Oncologist's Viewpoint 479
Treatment of Hepatocellular Carcinoma by Internists 485
The Surgeon's Perspective on Hepatic Radiofrequency Ablation 493
Radiofrequency Tumor Ablation in Children 502
Comments from Patients and Their Families 511
Index 529

Erscheint lt. Verlag 8.9.2008
Mitarbeit Anpassung von: Tito Livraghi, Peter R. Mueller, Stuart G. Silverman
Zusatzinfo XXIV, 542 p.
Verlagsort New York
Sprache englisch
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Chirurgie
Medizin / Pharmazie Medizinische Fachgebiete Onkologie
Medizinische Fachgebiete Radiologie / Bildgebende Verfahren Radiologie
Schlagworte angiogenesis • carcinoma • chemoembolization • Computed tomography (CT) • Imaging • Positron Emission Tomography • Radiaton Oncology • Radiology • Surgery • Tumor • Ultrasound
ISBN-10 0-387-28674-8 / 0387286748
ISBN-13 978-0-387-28674-7 / 9780387286747
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