Breast Cancer Management and Molecular Medicine (eBook)

Foreword 5
Contents 10
Contributors 35
Section 1 54
1 Role of Modeling in Pharmacotherapeutics 55
Section 2 80
2 PET and Nuclear Medicine Imaging of the Breast 82
3 Functional Radiologic Imaging in Breast Cancer 93
Section 3 111
4 Prevention of Breast Cancer 113
Section 4 145
5 DCIS: Pathology and Molecular Markers 148
6 Ductal Carcinoma In Situ: a Modern Approach to Patient Management 173
7 Ductal Carcinoma In Situ: Systemic Treatment 184
Section 5 204
8 Tailored Surgery for Early Breast Cancer: Surgical Techniques 207
9 Tailored Surgery for Early Breast Cancer: Biological Aspects 228
10 Tailored Surgery for Early Breast Cancer: the Very Young Woman 244
11 Tailored Surgery for Older Women with Breast Cancer 259
Section 6 273
12 Tailored Radiotherapy for Breast Cancer Stages I and II: Technical Aspects 278
13 Breast Cancer Management in the Era of Molecular Medicine: Tailored Radiotherapy – Clinical and Biological Aspects 300
14 Early Breast Cancer (Stage I and II): Tailored Radiotherapy for Very Young Women 322
15 The Elderly and Breast Cancer Radiotherapy 333
Section 7 348
16 Early Breast Cancer (Stage I and Stage II): Tailored Systemic Therapy for Endocrine- Resistant Breast Cancer 350
17 Early Breast Cancer (Stage I and Stage II): Tailored Systemic Therapy for Endocrine- Responsive Breast Cancer 368
18 Tailored Therapy for Breast Cancer in Very Young Women 390
19 Tailored Systemic Therapy for the Elderly Woman 416
Section 8 438
20 Locoregional Therapy Following Neoadjuvant Chemotherapy: an Evolving Paradigm of Treatment Individualization 441
21 Medical Therapy of Locally Advanced Breast Cancer 467
Section 9 488
22 Metastatic Breast Cancer: Tailored Endocrine Therapy for Premenopausal Women 489
23 Metastatic Breast Cancer: Tailored Endocrine Therapy for Postmenopausal Women 503
24 Metastatic Breast Cancer: Tailored Chemotherapy for the Elderly Woman 516
Section 10 540
25 Treatment of Brain Metastases from Breast Cancer 541
26 Surgical Management of Breast Cancer Liver Metastases 560
27 Individualization of Bisphosphonate Therapy 579
28 Breast Cancer Metastases to the Eye 599
29 Organ-Specific Approaches: Pain Management 602
Section 11 625
30 Genomic and Molecular Classification of Breast Cancer 626
31 Applications of Proteomics to Clinical Questions in Breast Cancer 653
Section 12 670
32 Targeting the HER Family of Receptors in the Treatment of Advanced Breast Cancer 671
33 Biological Therapies for Metastatic Breast Cancer: Antiangiogenesis 699
34 Breast Cancer Gene Therapy 733
35 Innovative Rational-Derived, Target- Based and Cytotoxic Therapies for Breast Cancer and Other Malignancies 769
Section 13 809
36 Mechanisms of Breast Cancer Resistance to Chemotherapy 810
37 Mechanisms of Resistance to Hormone Therapy 831
38 Novel Signaling Pathways in Breast Cancer 848
39 Mechanisms of Apoptosis Resistance In Breast Cancer 865
Section 14 883
40 Breast Cancer and Pregnancy 886
41 Hormone Replacement Therapy After Breast Cancer 902
42 Male Breast Cancer 926
43 Patients’ Preferences: What Makes Treatments Worthwhile? 947
44 Breast Cancer: the Impact of Depression and its Treatment 967
45 Molecular Profiling in Breast Cancer 998
46 Clinical Trials in the Era of Treatment Tailoring 1028
Subject Index 1042