Targeted Therapies in Cancer (eBook)

Preface 5
Contents 6
List of Contributors 9
Prediction of Tumor Behavior 13
Beyond Typing and Grading: Target Analysis in Individualized Therapy as a New Challenge for Tumour Pathology 14
Oncogenic Signaling Pathways and Deregulated Target Genes 18
Predictive Pathology of Cytostatic Drug Resistance and New Anti- cancer Targets 36
Prediction of Response to Neoadjuvant Chemotherapy in Carcinomas of the Upper Gastrointestinal Tract 44
Resistance-Associated Signatures in Breast Cancer 48
Resistance to Chemotherapy in Ovarian Carcinoma 62
Clinical, Biological, and Molecular Aspects of Metastasis in Colorectal Cancer 72
Prediction of Efficacy and Side Effects of Chemotherapy in Colorectal Cancer 92
Proteomic Expression Profiling of Breast Cancer 100
Targeted Therapy and Clinical Applications 132
Targeted Therapy and Blood– Brain Barrier 133
Cetuximab: Appraisal of a Novel Drug Against Colorectal Cancer 144
C- kit, GIST, and Imatinib 153
Antibody Therapy in Non- Hodgkin’s Lymphoma: The Role of Rituximab, 90Y- Ibritumomab Tiuxetan, and Alemtuzumab 160
Molecular and Clinical Aspects of Proteasome Inhibition in the Treatment of Cancer 171
Individualized Target Therapy of Malignant Lymphomas: An Outlook 183
Antiangiogenesis, Anti-VEGF( R) and Outlook 195
Morphological Detection of Hormone and Growth Factor Receptors in Breast Cancer 206
Prospects for Development 215
Antigen- Specific Cancer Vaccines 216
Therapeutic Vaccination for the Treatment of Malignant Melanoma 222
Monoclonal and Recombinant Antibodies with T Cell Receptor- Like Reactivity 231
New Molecular Therapy Targets in Acute Myeloid Leukemia 244