Tumor Prevention and Genetics III (eBook)

Contents 5
Lifestyle and Medical Approaches to Cancer Prevention 7
Application of Genetics to the Prevention of Colorectal Cancer 22
Genetics and Prevention of Oesophageal Adenocarcinoma 39
Preclinical Models Relevant to Diet, Exercise, and Cancer Risk 51
Individualizing Interventions for Cancer Prevention 66
Can Animal Models Help Us Select Specific Compounds for Cancer Prevention Trials? 73
Problems with Using Biomarkers as Surrogate End Points for Cancer: A Cautionary Tale 90
Can a Marker Be a Surrogate for Development of Cancer, and Would We Know It if It Exists? 100
How Should We Move the Field of Chemopreventive Agent Development Forward in a Productive Manner? 114
The Problems with Risk Selection Scientific and Psychosocial Aspects
Chemoprevention of Lung Cancer 146
Anti-nicotine Vaccination: Where Are We? 167
Primary Prevention of Colorectal Cancer: Lifestyle, Nutrition, Exercise 176
Chemoprevention of Colorectal Cancer: Ready for Routine Use? 211
Screening of Colorectal Cancer: Progress and Problems 229
The Role of Endogenous Hormones in the Etiology and Prevention of Breast Cancer: The Epidemiological Evidence 243
Innovative Agents in Cancer Prevention 255
The IARC Commitment to Cancer Prevention: The Example of Papillomavirus and Cervical Cancer 274
Health Economics in the Genomic Age 295
Screening for Cancer: Are Resources Being Used Wisely? 310