Advances in Radiation Oncology in Lung Cancer (eBook)

Foreword 6
Preface 7
Contents 8
1 Pretreatment Considerations 11
1.1 Molecular Biology and Genetics of Lung Cancer 12
1.2 Angiogenesis and Lung Cancer 21
1.3 Contemporary Issues in Staging of Lung Cancer 39
2 Basic Treatment Considerations 53
2.1 Lung Cancer Surgery 54
2.2 Radiation Therapy 66
2.2.1 Radiobiology of Normal Lung Tissue and Lung Tumours 66
2.2.2 Radiation Time, Dose, and Fractionation in the Treatment of Lung Cancer 73
2.2.3 Treatment Planning and Conformal Radiotherapy 82
2.2.4 Target Volumes in Non-Small Cell Lung Cancer 101
2.2.5 Target Volumes in Small Cell Lung Cancer 115
2.2.6 Radioprotectors and Chemoprotectors in the Management of Lung Cancer 126
2.3 Lung Cancer Chemotherapy for Radiation Oncologists 138
2.4 Radiotherapy and Chemotherapy 158
3 Current Treatment Strategies in Non- Small Cell Lung Cancer 170
3.1 Early Stage in Non-Small Cell Lung Cancer 171
3.1.1 Radiotherapy in Early Stage Non-Small Cell Lung Cancer 171
3.1.2 Postoperative Radiotherapy for Non- Small Cell Lung Carcinoma 191
3.1.3 Photodynamic Therapy 201
3.2 Locally Advanced Non-Small Lung Cancer 208
3.2.1 Radiochemotherapy in Locally Advanced Non-Small Cell Lung Cancer 208
3.2.2 Chemotherapy or Chemoradiotherapy Followed by Surgical Resection for Non- Small Cell Lung Cancer 224
3.2.3 Palliative External Beam Thoracic Radiotherapy 248
3.2.4 Intraoperative Electron Beam Radiotherapy in Lung Cancer 256
3.2.5 Intraluminal Radiotherapy 270
4 Treatment of Small- Cell Lung Cancer 276
4.1 Limited-Disease of Small Cell Lung Cancer 277
4.2 Prophylactic Cranial Irradiation in Small Cell Lung Cancer 287
5 Radiation Therapy for Recurrent Lung Cancer 296
6 Radiotherapy for Lung Cancer in Elderly Patient 307
7 Advances in Supportive and Palliative Care for Lung Cancer Patients 319
8 Treatment-Related Toxicity 335
8.1 Hematologic Toxicity in Lung Cancer 336
8.2 Radiation-Induced Lung and Heart Toxicity 348
8.3 Spinal Cord 363
8.4 Radiation Therapy-Related Toxicity: Esophagus 369
8.5 Brain Toxicity 379
9 Quality of Life in Radiation Oncology of Lung Cancer 390
10 Prognostic Factors in Lung Cancer 405
11 Future Strategies in Lung Cancer 415
11.1 Intensity-Modulated Radiation Therapy for Lung Cancer 416
11.2 Stereotactic Radiotherapy and Gated Therapy 427
11.3 Novel Substances in the Treatment of Lung Cancer for the Radiation Oncologist 438
11.4 PET Scanning in Staging and Evaluation of Response to Treatment in Lung Cancer 452
11.5 Heavy Particles in Lung Cancer 463
11.6 Translational Research in Radiation Oncology of Lung Cancer 470
12 Pitfalls in the Design, Conduct and Analysis of Randomised Clinical Trials 483
13 New Directions in the Evaluation and Presentation of Clinical Research in Lung Cancer 492
Subject Index 500
List of Contributors 503