Regenerative and Cell Therapy (eBook)

Preface 5
Contents 7
List of Editors and Contriiutors 9
Editors 9
Coeditors 9
Contributors 10
Problems and Hopes with Cell Therapy: The Case of Muscular Dystrophy 13
Introduction 13
Early Attempts with Myoblasts Transplantation 15
Why Bone Marrow Transplantation 16
Multipotent Stem Cells in the Bone Marrow 18
Stem Cells with a Myogenic Potential from Tissues Other than Bone Marrow 22
The Cellular Environment of a Dystrophic Muscle 23
Future Perspectives 26
References 27
Cardiac Myoilasts 33
Introduction 33
Basic Assumptions 34
Skeletal Myoblasts for Cardiac Repair Experimental Studies 35
Skeletal Myoblasts for Cardiac Repair Clinical Studies 39
Skeletal Myoblasts for Cardiac Repair Future Directions 41
References 44
Tissue Engineering Stem Cells and Cloning: Current Concepts and Future Trends 47
Introduction 48
Tissue Engineering Principles 49
Stem Cells 51
Therapeutic Cloning 52
Biomaterials for Regenerative Medicine 54
Tissue Engineering of Specific Structures 57
Cellular Therapies 66
Conclusions 70
References 70
Bone Marrow Cell Therapy for Genetic Disorders of Bone 80
Osteogenesis Imperfecta 81
Overview of Clinical Trials 82
Bone Marrow Transplantation 84
Mesenchymal Cell Transplantation 86
Developmental Outcome 89
Conclusions 89
References 90
Immune Based Cell Therapy for Acute and Chronic Neurodegenerative Disorders 92
Immune Based Therapies for CNS Injuries 92
Spinal Cord Injury and Immune Intervention 94
Protective Autoimmunity A Physiological Response to CNS Insult 95
Regulation of Protective Autoimmunity and the Mechanism Underlying It 98
Dendritic Cells A Therapeutic Immune Cell Based Therapy Linking Adaptive and Innate Immunity 100
A Therapeutic Vaccine for Neurodegenerative Diseases 101
Concluding Remarks 102
References 103
Mesenchymal Stem Cells for the Treatment of Hematological Malignancies 108
Introduction 108
Mesenchymal Stem Cells in HSCT 109
Mesenchymal Stem Cells for Bone Marrow Failure 115
Conclusion 116
References 116
Perspectives in Transfusion Medicine for the Ex Vivo Control of Hematopoiesis 119
In Vitro Control of the Proliferation and Differentiation of Hematopoietic Stem Cells 119
Enucleation A Complex and Poorly Understood Phenomenon 122
In Vivo Fate of the Erythroblast Precursors Produced In Vitro 125
A Quantitative Challenge for Use in Transfusion 126
References 128
T Cell Therapies for EBV-Associated Malignancies 130
Introduction 130
Type Latency Posttransplant Lymphoproliferative Disease 131
Type Latency Hodgkin s Disease 133
Improving the Efficacy of Infused CTL 134
Type Latency Nasopharyngeal Carcinoma 136
Conclusion 137
References 137
Peptide Vaccination of Myeloid Leukemia 140
Introduction 140
Potential Target Antigens 142
Clinical Trial 147
Conclusion 148
References 148
Hematopoietic Cell Transplantation after Nonmyeloailative Conditioning 154
Introduction 155
GVT Effect 156
Preclinical Data from a Canine Model 158
Clinical Application of Nonmyeloablative Conditioning for HCT 165
Reduced Intensity HCT Results from Other Centers 171
References 177