Bone Metastases (eBook)
XVI, 400 Seiten
Springer Netherland (Verlag)
978-1-4020-9819-2 (ISBN)
Bone Metastases: A Translational and Clinical Approach serves as both an introductory and reference book focusing on the field of metastatic bone disease. Featuring contributions from experts in the field, this volume:
- describes the molecular and cellular mechanisms involved in the formation of bone metastases,
- comments on the role of angiogenesis,
- presents the newer advances made in the understanding of the clinical picture and symptoms of patients,
- analyses the role of bone markers in research and clinical practice
- deals with all aspects of imaging modalities applied for the detection and evaluation of bone metastases.
This volume also covers the use of radiotherapy, surgery and systemic treatments for the management of metastatic bone disease and new therapeutic approaches. Moreover it may also serve as a guide for the clinical and therapeutic management of patients with metastatic bone disease.
Overall this volume presents a thorough overview of all aspects of metastatic bone disease and provides a comprehensive and concise information resource for medical researchers, oncologists, orthopaedic surgeons and clinicians.
Bone Metastases: A Translational and Clinical Approach serves as both an introductory and reference book focusing on the field of metastatic bone disease. Featuring contributions from experts in the field, this volume: describes the molecular and cellular mechanisms involved in the formation of bone metastases, comments on the role of angiogenesis, presents the newer advances made in the understanding of the clinical picture and symptoms of patients, analyses the role of bone markers in research and clinical practice deals with all aspects of imaging modalities applied for the detection and evaluation of bone metastases. This volume also covers the use of radiotherapy, surgery and systemic treatments for the management of metastatic bone disease and new therapeutic approaches. Moreover it may also serve as a guide for the clinical and therapeutic management of patients with metastatic bone disease.Overall this volume presents a thorough overview of all aspects of metastatic bone disease and provides a comprehensive and concise information resource for medical researchers, oncologists, orthopaedic surgeons and clinicians.
Preface by Editors 7
Contents 9
Contributors 12
Part I Fundamental Concepts of Bone Metastases 16
BONE ANATOMY, PHYSIOLOGY AND FUNCTION 17
PATHOPHYSIOLOGY OF BONE METASTASES 44
ANGIOGENESIS AND BONE METASTASIS: IMPLICATIONS FOR DIAGNOSIS, PREVENTION AND TREATMENT 64
NATURAL HISTORY, PROGNOSIS, CLINICAL FEATURES AND COMPLICATIONS OF METASTATIC BONE DISEASE 90
BONE BIOMARKERS IN RESEARCH AND CLINICAL PRACTICE 106
Part II Imaging Modalities 130
RADIOLOGIC EVALUATION OF SKELETAL METASTASES: ROLE OF PLAIN RADIOGRAPHS AND COMPUTED TOMOGRAPHY 131
THE CONTRIBUTION OF NUCLEAR MEDICINE IN THE DIAGNOSIS OF BONE METASTASES 149
MAGNETIC RESONANCE IMAGING OF METASTATIC BONE DISEASE 174
Part III Therapeutic Strategies 193
RADIOTHERAPY AND BONE METASTASES 194
BIPHOSPHONATES IN THE MANAGEMENT OF METASTATIC BONE DISEASE 203
COMBINED RADIOTHERAPY AND BISPHOSPHONATES: STATE OF ART 240
BIPHOSPHONATES IN THE TREATMENT OF BONE METASTASES – OSTEONECROSIS OF THE JAW 258
SURGICAL MANAGEMENT OF BONE METASTASES 270
THE ROLE OF CHEMOTHERAPY IN THE TREATMENT OF BONE METASTASES 294
HORMONOTHERAPY OF BONE METASTASES 305
RADIONUCLIDE THERAPY 327
Part IV Assessment of Therapeutic Response 348
ASSESSMENT OF THERAPEUTIC RESPONSE 349
OUTCOME MEASURES IN BONE METASTASES CLINICAL TRIALS 375
Index 399
| Erscheint lt. Verlag | 21.7.2009 |
|---|---|
| Reihe/Serie | Cancer Metastasis - Biology and Treatment | Cancer Metastasis - Biology and Treatment |
| Zusatzinfo | XVI, 400 p. |
| Verlagsort | Dordrecht |
| Sprache | englisch |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie |
| Medizin / Pharmazie ► Medizinische Fachgebiete ► Orthopädie | |
| Medizin / Pharmazie ► Studium | |
| Schlagworte | angiogenesis • Bisphosphonates • Bone Metastases • Chemotherapy • clinical trial • Computed tomography (CT) • hormones • Imaging • Magnetic Resonance Imaging (MRI) • Metastasis • necrosis • pathophysiology • Physiology • prevention • radiotherapy • Surgery |
| ISBN-10 | 1-4020-9819-7 / 1402098197 |
| ISBN-13 | 978-1-4020-9819-2 / 9781402098192 |
| Haben Sie eine Frage zum Produkt? |
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