Cerebral Hemorrhage (eBook)

Preface 6
Acknowledgments 7
Contents 8
Julian Theodore (Buz) Hoff 1936– 2007 12
Hoff Fellowships 14
Experimental intracerebral hemorrhage – iron, hemoglobin and free radicals 15
Deferoxamine therapy for intracerebral hemorrhage 16
Bilirubin oxidation products, oxidative stress, and intracerebral hemorrhage 20
Deferoxamine reduces brain swelling in a rat model of hippocampal intracerebral hemorrhage 26
The antioxidant effects of melatonin after intracerebral hemorrhage in rats 32
Poly(ADP-ribose) polymerase activation and brain edema formation by hemoglobin after intracerebral hemorrhage in rats 35
Induction of autophagy in rat hippocampus and cultured neurons by iron 40
Effects of superoxide dismutase and catalase derivates on intracerebral hemorrhage- induced brain injury in rats 44
Metallothionein and brain injury after intracerebral hemorrhage 47
Experimental intracerebral hemorrhage – inflammation and thrombin 51
Intracerebral hemorrhage injury mechanisms: glutamate neurotoxicity, thrombin, and Src 52
Increase in brain thrombin activity after experimental intracerebral hemorrhage 56
Microglial activation and intracerebral hemorrhage 60
Concomitant intracerebral infusion of tissue plasminogen activator and thrombin leads to brain injury 63
Microglial activation and brain injury after intracerebral hemorrhage 67
Effects of aging on complement activation and neutrophil infiltration after intracerebral hemorrhage 74
Experimental intracerebral hemorrhage – other mechanisms 78
Blood– brain barrier function in intracerebral hemorrhage 79
Treatment of stroke and intracerebral hemorrhage with cellular and pharmacological restorative therapies 84
Deficiency of CD18 gene reduces brain edema in experimental intracerebral hemorrhage in mice 89
Tissue inhibitor of matrix metalloproteinases-3 (TIMP-3) lacks involvement in bacterial collagenase- induced intracerebral hemorrhage in mouse 92
Radial glia marker expression following experimental intracerebral hemorrhage 97
Long-term effects of melatonin after intracerebral hemorrhage in rats 100
Management of delayed edema formation after fibrinolytic therapy for intracerebral hematomas: preliminary experimental data 102
Erythropoietin attenuates intracerebral hemorrhage by diminishing matrix metalloproteinases and maintaining blood– brain barrier integrity in mice 106
Hyperbaric oxygen for experimental intracerebral hemorrhage 114
Effect of amantadine sulphate on intracerebral hemorrhage-induced brain injury in rats 119
Experimental intracerebral hemorrhage – model development and characterization 122
Long-term behavioral characterization of a rat model of intracerebral hemorrhage 123
Neurological deficits and brain edema after intracerebral hemorrhage in Mongolian gerbils 125
Rat model of intracerebellar hemorrhage 129
A rat model of pontine hemorrhage 133
Human intracerebral hemorrhage 136
The optimal time-window for surgical treatment of spontaneous intracerebral hemorrhage: result of prospective randomized controlled trial of 500 cases 137
Preliminary findings of the minimally-invasive surgery plus rtPA for intracerebral hemorrhage evacuation ( MISTIE) clinical trial 142
Pediatric cerebrovascular diseases: report of 204 cases 147
Xenon-CT study of regional cerebral blood flow around hematoma in patients with basal ganglia hemorrhage 154
Preliminary application of pyramidal tractography in evaluating prognosis of patients with hypertensive intracerebral hemorrhage 158
Experimental intracranial hemorrhage (non-intracerebral hemorrhage) 164
Mechanisms and markers for hemorrhagic transformation after stroke 165
The clinical significance of acute brain injury in subarachnoid hemorrhage and opportunity for intervention 171
Development of a cerebral microvascular dysplasia model in rodents 177
Hyperbaric oxygen preconditioning protects against traumatic brain injury at high altitude 182
Human intracranial hemorrhage (non-intracerebral hemorrhage) 188
Genetic considerations relevant to intracranial hemorrhage and brain arteriovenous malformations 189
Vasospasm after aneurysmal subarachnoid hemorrhage: need for further study 197
Regional cerebral blood flow and oxygen metabolism in aneurysmal subarachnoid hemorrhage: positron emission tomography evaluation of clipping versus coiling 201
Preliminary report of the clot lysis evaluating accelerated resolution of intraventricular hemorrhage ( CLEAR- IVH) clinical trial 206
Leptin plays a role in ruptured human brain arteriovenous malformations 210
Novel treatments for cerebral vasospasm following aneurysmal subarachnoid hemorrhage 214
Relationship between serum sodium level and brain ventricle size after aneurysmal subarachnoid hemorrhage 218
Lack of association between apolipoprotein E promoters in e4 carriers and worsening on computed tomography in early stage of traumatic brain injury 222
Author index 226
Index of keywords 228