Oxidants in Biology (eBook)

A Question of Balance

Giuseppe Valacchi (Herausgeber)

eBook Download: PDF
2008 | 2008
VIII, 328 Seiten
Springer Netherland (Verlag)
978-1-4020-8399-0 (ISBN)

Lese- und Medienproben

Oxidants in Biology -
Systemvoraussetzungen
223,63 inkl. MwSt
  • Download sofort lieferbar
  • Zahlungsarten anzeigen

Oxidants, like other aspects of life, involves tradeoffs. Oxidants, whether intentionally produced or by-products of normal metabolism can either mediate a variety of critical biological processes but when present inappropriately cause extensive damage to biological molecules (DNA, proteins, and lipids). These effects can lead to either damage that is a major contributor to aging and degenerative diseases (or to other diseases such as cancer, cardiovascular disease, immune-system decline, brain dysfunction, and cataracts) or normal physiological function- tissue repair, defense against pathogens and cellular proliferation. On the other hand the body is equipped with a complex antioxidant/oxidant handling system which includes both enzymatic and nonenzymatic (i.e. small molecules such as flavonoids, ascorbate, tocopherol, and carotenoids) produced endogenously or derived from the diet. This book focuses on how the same molecules can have favorable or noxious effects depending on location, level and timing.

Each chapter focuses on one particular molecule or oxidant/antioxidant system and provides a state of the art review of the current understanding regarding both positive and negative actions of the system under review.


Oxidants, like other aspects of life, involves tradeoffs. Oxidants, whether intentionally produced or by-products of normal metabolism can either mediate a variety of critical biological processes but when present inappropriately cause extensive damage to biological molecules (DNA, proteins, and lipids). These effects can lead to either damage that is a major contributor to aging and degenerative diseases (or to other diseases such as cancer, cardiovascular disease, immune-system decline, brain dysfunction, and cataracts) or normal physiological function- tissue repair, defense against pathogens and cellular proliferation. On the other hand the body is equipped with a complex antioxidant/oxidant handling system which includes both enzymatic and nonenzymatic (i.e. small molecules such as flavonoids, ascorbate, tocopherol, and carotenoids) produced endogenously or derived from the diet. This book focuses on how the same molecules can have favorable or noxious effects depending on location, level and timing.Each chapter focuses on one particular molecule or oxidant/antioxidant system and provides a state of the art review of the current understanding regarding both positive and negative actions of the system under review.

Preface by Valacchi G and Davis PA; OLD PLAYERS: 1. Hydrogen Peroxide, the good, the bad and the ugly, Henry Forman; 2. Peroxynitrite, a Key Molecule in Skin Tissue Response to Different Types of Stress, Meital Portugal and Ron Kohen; 3. Cellular and Environmental Electrophiles: Balancing Redox Signaling, Inflammation, and Cell Death Pathways, Albert van der Vliet*, Milena Hristova, Sean McCarthy and David Kasahara; 4. The role of reactive nitrogen species (RNS) in the activation of nuclear factor kappa B (NFkB) and its implications for biological systems-the question of balance, Predrag Ljubuncic, Marina Bar-Shai and Abraham Z. Reznick; 5. Neutrophil-derived oxidants as modulators of polyunsaturated fatty acid metabolism, Lukas Kubala and Antonin Lojek; 6. Fatty acids in modulation of reactive oxygen species balance in cancer, Jirina Hofmanová, Karel Soucek, Alena Vaculova and Alois Kozubík; 7. The question of balance: the interaction between blood and ozone, Velio Bocci; 8. Iron and erythrocytes: physiological and pathophysiological aspects, Lucia Ciccoli, Silvia Leoncini, Cinzia Signorini and Mario Comporti; 9. The adventures of superoxide dismutase in health and disease: Superoxide in the balance, Kristy M. Powers, Larry W. Oberley and Frederick E. Domann; 10. Glutathione metabolism: favorable vs unfavorable effects, Cimino Francesco and Saija Antonina; 11. Dual role of oxidative stress in the lungs, Tzipora Goldkorn and Elaine Khan; 12. Antioxidants: how they work, Elisabetta Damiani, Paola Astolfi, Patricia Carloni, Pierluigi Stipa and Lucedio Greci; NEW PLAYERS: 13. The role of DUOX isozymes in the respiratory tract epithelium, Richard Harper; 14. Hypertension, diabetes, oxidative stress and cardiovascular remodeling: making the connection with p66shc, Elisa Pagnin, Angelo Avogaro and Lorenzo A Calò; 15. A role of BRCA1-associated protein BARD1 in oxidative stress response and signaling and proliferation control,Irmgard Irminger-Finger and Shazib Pervais; 16. Postprandial events as a trigger for redox unbalance: role of dietary lipid hydroperoxides and antioxidants, Fausta Natella, Arianna Ramberti and Cristina Scaccini; 17. F2-Isoprostanes: markers and mediators of an imbalanced redox status in the liver, Concetta Gardi, Beatrice Arezzini, Cinzia Signorini, Daniela Vecchio, Barbara Monaco and Mario Comporti; Index

Erscheint lt. Verlag 6.6.2008
Mitarbeit Stellvertretende Herausgeber: Paul A. Davis
Zusatzinfo VIII, 328 p.
Verlagsort Dordrecht
Sprache englisch
Themenwelt Medizin / Pharmazie Gesundheitsfachberufe
Medizin / Pharmazie Medizinische Fachgebiete Pharmakologie / Pharmakotherapie
Medizin / Pharmazie Pharmazie
Naturwissenschaften Biologie
Naturwissenschaften Chemie
Technik
Schlagworte Activation • Diabetes • DNA • Drogen • electrophile • Endoplasmatisches Reticulum • Hydrogen Peroxide • lead • proteins
ISBN-10 1-4020-8399-8 / 1402083998
ISBN-13 978-1-4020-8399-0 / 9781402083990
Haben Sie eine Frage zum Produkt?
PDFPDF (Wasserzeichen)
Größe: 7,6 MB

DRM: Digitales Wasserzeichen
Dieses eBook enthält ein digitales Wasser­zeichen und ist damit für Sie persona­lisiert. Bei einer missbräuch­lichen Weiter­gabe des eBooks an Dritte ist eine Rück­ver­folgung an die Quelle möglich.

Dateiformat: PDF (Portable Document Format)
Mit einem festen Seiten­layout eignet sich die PDF besonders für Fach­bücher mit Spalten, Tabellen und Abbild­ungen. Eine PDF kann auf fast allen Geräten ange­zeigt werden, ist aber für kleine Displays (Smart­phone, eReader) nur einge­schränkt geeignet.

Systemvoraussetzungen:
PC/Mac: Mit einem PC oder Mac können Sie dieses eBook lesen. Sie benötigen dafür einen PDF-Viewer - z.B. den Adobe Reader oder Adobe Digital Editions.
eReader: Dieses eBook kann mit (fast) allen eBook-Readern gelesen werden. Mit dem amazon-Kindle ist es aber nicht kompatibel.
Smartphone/Tablet: Egal ob Apple oder Android, dieses eBook können Sie lesen. Sie benötigen dafür einen PDF-Viewer - z.B. die kostenlose Adobe Digital Editions-App.

Zusätzliches Feature: Online Lesen
Dieses eBook können Sie zusätzlich zum Download auch online im Webbrowser lesen.

Buying eBooks from abroad
For tax law reasons we can sell eBooks just within Germany and Switzerland. Regrettably we cannot fulfill eBook-orders from other countries.

Mehr entdecken
aus dem Bereich