Diseases of the Pancreas (eBook)

Preface 5
Contents 6
Contributors 11
Anatomy of the Pancreas 21
Development of the Pancreas and Response to Disease 22
Congenital Anomalies of the Pancreas and the Extrahepatic Bile Ducts 28
Surgical Vascular Anatomy and Histology 37
Physiology and Pathophysiology of the Pancreatic Functions 47
Pancreatic Exocrine Secretion 48
Physiology and Patho-physiology of Endocrine Pancreatic Secretion 53
Sphincter of Oddi Physiology and Pathophysiology 65
Clinical Standards of Diagnostic Measures 75
Ultrasound 76
Contrast-Enhanced CT and MRI 82
Endoscopic Retrograde Cholangiopancreatography 90
Fine-Needle Aspiration Biopsy of the Pancreas 100
FDG-PET and PET/CT in Pancreatic Cancer 111
Laboratory Diagnosis of Exocrine and Endocrine Dysfunctions in Inflammatoryand Neoplastic Lesions 120
Guidelines, Clinical Evaluation, Short Track 132
Acute Pancreatitis 142
Etiology and Epidemiology of Acute Pancreatitis 144
Pathogenesis and Pathophysiology of Acute Pancreatitis 166
Natural Course of Acute Pancreatitis 176
Classification of Severe Acute Pancreatitis 186
Biochemical Diagnosis, Staging, and Prediction 193
Imaging Diagnosis of Acute Pancreatitis 205
Nonsurgical Management of Acute Pancreatitis 215
Indications for the Surgical Management of Necrotizing Pancreatitis 223
Debridement and Closed Packing for the Treatment of Necrotizing Pancreatitis 230
Necrosectomy and Redressing 236
Necrosectomy and Closed Lavage 242
Infected Necrosis – Minimally Invasive Necrosectomy 252
Benefits and Limitations of Necrosectomy 260
Surgical Management of Pancreatic Abscess 264
Surgical Management of Pseudocysts after Acute Pancreatitis 270
Interventional Management of Pancreatic Fluid Collections and Abscesses 282
Pancreatic and Intestinal Fistulas 291
Late Outcome after Necrosectomy 299
Chronic Pancreatitis 303
Mechanisms of Pain in Chronic Pancreatitis 305
Natural Course of Chronic Pancreatitis 310
Chronic Pancreatitis:Inflammatory Mass in the Headof the Pancreas – Pacemakerof Chronic Pancreatitis 319
Diagnosis: Functional Testing, Radiological Work-up of Chronic Pancreatitis 326
Medical Management of Chronic Pancreatitis 338
Tropical Chronic Pancreatitis 355
Hereditary Chronic Pancreatitis: Diagnosis and Management 366
Endoscopic Interventional Treatment 377
Pancreatic Duct Drainage Procedures 389
Duodenum-Preserving Pancreatic Head Resection 401
Pancreaticoduodenctomy for Chronic Pancreatitis– With or Without Pylorus Preservation 415
Central Pancreatectomy 426
Distal Pancreatectomy in Patients with Chronic Pancreatitis 442
Total Pancreatectomy 453
Surgical Treatment of Pseudocysts in Chronic Pancreatitis 458
Late Outcome After Medical and Surgical Treatment of Chronic Pancreatitis 475
Pancreatic Cancer 485
Epidemiology of Pancreatic Cancer 487
Pathology of Pancreatic Cancer 495
Genetic Pathways in Pancreatic Tumorigenesis 510
The Clinical Assessment of Pancreatic Cancer 524
The Staging of Pancreatic Cancer 538
Oncological Management of Pancreatic Cancer in Advanced Stages 546
Indications for Resection of Pancreatic Cancer 555
The Kausch-Whipple Pancreatectomy 562
Pylorus-Preserving Pancreaticoduodenectomy 575
Management of TumorInvasion/Adhesion to the Superior Mesenteric-Portal Vein During Pancreatectomy 586
Subtotal Left Resection for Pancreatic Cancer 616
Total Pancreatectomy for Pancreatic Cancer 630
Laparoscopic Management of Pancreatic Neoplasms 643
Bypass Procedures in the Treatment of Nonresectable Carcinoma of the Head of the Pancreas 655
Resected Pancreatic Cancer 665
Management of Locally Advanced and Recurrent Pancreas Cancer 678
Survival After Medical and Surgical Treatment of Pancreatic Adenocarcinoma 684
Endocrine Tumors of the Pancreas 694
Pancreatic Endocrine Tumors: Epidemiology, Pathology, Pathophysiology, and Diagnosis 695
Surgical Treatment of Insulinomas 702
Surgical Treatment of the Gastrinoma 710
Surgical Treatment of Rare Endocrine Tumors 722
Outcome after Surgical Treatment of Endocrine Pancreatic Tumors 735
Periampullary Tumors 739
Histopathology of Tumors of the Papilla of Vater 740
Clinical Diagnosis of Adenoma of the Papilla of Vater 750
Clinical Diagnosis of Periampullary Carcinoma 756
Endoscopic Management of Adenoma 763
Surgical Management of Adenoma 772
Surgical Treatment of Carcinoma of the Ampulla of Vater 779
Surgical Resection of Distal Common Bile Duct Carcinoma 789
Cancer of the Duodenum – Surgical Treatment 798
Long-Term Outcome After Resection of Periampullary Carcinoma 808
Cystic Neoplasia of the Pancreas 817
Cystic Neoplasms of the Pancreas – Pathological Aspects 818
Clinical Diagnosis and Staging 822
Surgical Treatment of Cystic Tumors of the Pancreas 828
Congenital Anomalies of the Pancreas 849
Congenital Cysts: Diagnosis, Clinical Impact, and Management 850
Pancreas Divisum – Diagnosis and Endoscopic Management 857
Surgical Treatment of Pancreas Divisum 866
Biliopancreatic Maljunction: Classification, Diagnosis, and Treatment 870
Pancreatic Injury 877
Pancreatic Trauma: Diagnosis, Treatment, Complications, and Late Outcome 878
Transplantation of the Pancreas 884
Islet Transplantation and Results 885
Pancreas Transplantation 893
Subject Index 909