Interferon: The 50th Anniversary (eBook)

Preface 5
List of Contents 7
List of Contributors 9
Part I: Reflections 10
How to Chase a Red Herring and Come up with a Smallmouth Bass 11
Interferon Research BC (Before Cloning) 16
Purification and Cloning of Interferon Alpha 30
Part II: Interferons and Their Signaling Pathways 45
Type I Interferon: The Ever Unfolding Story 46
The Receptor of the Type I Interferon Family 76
IFN-. : Recent Advances in Understanding Regulationof Expression, Biological Functions, and Clinical Applications 101
Cell Type-Specific Signaling in Response to Interferon-y 122
Interferon Research: Impact on Understanding Transcriptional Control 158
Part III: Recognition of Pathogens, Molecular Mechanism of Interferon Beta Induction 167
TLR-Mediated Activation of Type I IFN During Antiviral Immune Responses: Fighting the Battle to Win the War 168
Regulation of Antiviral Innate Immune Responses by RIG- I Family of RNA Helicases 194
Beyond Double-Stranded RNA-Type I IFN Induction by 3pRNA and Other Viral Nucleic Acids 207
Part IV: Interferon-Induced Genes 231
The Interferon-Stimulated Genes: Targets of Direct Signaling by Interferons, Double- Stranded RNA, and Viruses 232
Part IV: Interferon-Induced Genes 250
Structure and Function of the Protein Kinase R 251
Part V: Virus Defense 291
Viral Regulation and Evasion of the Host Response 292
Pathogenic Viruses: Smart Manipulators of the Interferon System 311
Part VI: Role of Interferon in Viral Infection and Autoimmunity 331
Type I Interferon During Viral Infections: Multiple Triggers for a Multifunctional Mediator 332
Type I Interferon in Systemic Lupus Erythematosus 353
Index 381