Modern Hematology (eBook)
XIV, 498 Seiten
Humana Press (Verlag)
978-1-59745-149-9 (ISBN)
Now in its second edition, Modern Hematology: Biology and Clinical Management reflects the major advances in the understanding, diagnosis, and treatment of blood disorders. It describes the latest clinical and scientific developments as well as details targeted and molecular therapies. The book brings together facts, concepts, and protocols important for the practice of hematology. In 23 chapters, all major blood diseases are covered, as well as rare diseases that are of scientific interest. As in the previous edition, each chapter is illustrated by tables, figures, and a selection of color plates.
Over the past few decades the powerful methods of statistical physics and Euclidean quantum field theory have moved closer together, with common tools based on the use of path integrals. The interpretation of Euclidean field theories as particular systems of statistical physics has opened up new avenues for understanding strongly coupled quantum systems or quantum field theories at zero or finite temperatures. Accordingly, the first chapters of this book contain a self-contained introduction to path integrals in Euclidean quantum mechanics and statistical mechanics. The resulting high-dimensional integrals can be estimated with the help of Monte Carlo simulations based on Markov processes. The most commonly used algorithms are presented in detail so as to prepare the reader for the use of high-performance computers as an "e;experimental"e; tool for this burgeoning field of theoretical physics. Several chapters are then devoted to an introduction to simple lattice field theories and a variety of spin systems with discrete and continuous spins, where the ubiquitous Ising model serves as an ideal guide for introducing the fascinating area of phase transitions. As an alternative to the lattice formulation of quantum field theories, variants of the flexible renormalization group methods are discussed in detail. Since, according to our present-day knowledge, all fundamental interactions in nature are described by gauge theories, the remaining chapters of the book deal with gauge theories without and with matter. This text is based on course-tested notes for graduate students and, as such, its style is essentially pedagogical, requiring only some basics of mathematics, statistical physics, and quantum field theory. Yet it also contains some more sophisticated conceptswhich may be useful to active researchers in the field. Each chapter ends with a number of problems - guiding the reader to a deeper understanding of some of the material presented in the main text - and, in most cases, also features some listings of short, useful computer programs.
FOREWORD 6
PREFACE 7
CONTENTS 8
CONTRIBUTORS 10
COLOR PLATES 11
1 Basic Biology of Hemopoiesis 12
CONTENTS 12
1. INTRODUCTION 12
2. COMPONENTS OF BLOOD AND BONE MARROW 13
3. ERYTHROPOIESIS 16
3.1. Hemoglobin 17
3.2. Iron Metabolism 18
3.3. The Red Blood Cell 19
4. MYELOPOIESIS 20
4.1. Eosinophils 21
4.2. Basophils 21
4.3. Mast Cells 21
4.4. Monocytes 22
4.5. Macrophages 22
4.6. Dendritic Cells 22
5. MEGAKARYOPOIESIS 23
6. LYMPHATIC TISSUES AND IMMUNE RESPONSE 6.1. Development and Organs of the Lymphoid System 23
6.1. Development and Organs of the Lymphoid System 23
6.2. B-Lymphocytes 24
6.3. T-Lymphocytes 25
6.4. Natural Killer Cells 25
7. PLASMA COMPONENTS 26
8. DIAGNOSTIC PROCEDURES IN HEMATOLOGY 26
8.1. Bone Marrow Aspiration 26
8.2. Bone Marrow Biopsy 28
8.3. Peripheral Blood Film 29
SUGGESTED READING 29
2 Molecular Biology and Cytokines 30
CONTENTS 30
1. INTRODUCTION 30
2. RECOMBINANT DNA TECHNOLOGY 31
3. CLONALITY OF TUMORS 31
3.1. Cytogenetics 32
3.2. Molecular Cytogenetics 33
3.3. Rearrangement of Immunoglobulin Genes or of the T- Cell Receptor 33
3.4. Light-Chain Restriction 34
3.5. Loss of Heterozygosity 34
3.6. X-Inactivation Assays 34
3.7. Small RNA Molecules in Hematology 35
4. DIAGNOSTIC APPLICATIONS OF MOLECULAR BIOLOGY AND GENE THERAPY 36
4.1. Viral Vectors and Gene Delivery Systems 37
4.2. Nonviral Vector Systems 38
4.3. Clinical Gene Therapy Protocols 38
5. CYTOKINES 40
5.1. Colony- Stimulating Factors 40
5.2. Pegfilgrastim 43
5.3. Thrombopoietin 43
5.4. Erythropoietin 44
5.5. Darbepoietin- 45
5.6. Stem Cell Factor 48
5.7. FLT3 Ligand 48
5.8. Tumor Necrosis Factor- 49
5.9. Fas Ligand 49
5.10. TNF-Related Apoptosis-Inducing Ligand 49
5.11. Transforming Growth Factor- 49
5.12. Interleukins 50
5.13. Interferons 50
SUGGESTED READING 51
3 Supportive Care in Hematology 52
CONTENTS 52
1. INTRODUCTION 52
2. DIAGNOSING SUSPECTED INFECTION IN NEUTROPENIC PATIENTS 53
3. TREATING INFECTIONS IN NEUTROPENIC PATIENTS 55
3.1. Empirical Treatment 57
3.2. Documented Bacterial Infections 59
3.3. Documented Fungal Infections 60
4. PROPHYLAXIS OF INFECTIONS IN NEUTROPENIC PATIENTS 65
5. VENOUS ACCESS 67
6. FURTHER CONSIDERATIONS 68
REFERENCES 69
4 Transplantation of Stem Cells From Bone Marrow, Peripheral Blood, and the Umbilical Cord 73
CONTENTS 73
1. DEFINITIONS AND INTRODUCTION 73
2. INDICATIONS FOR SCT 74
3. SELECTION OF A TRANSPLANT TYPE 75
4. STEM CELL DONOR SELECTION AND EVALUATION 76
5. UMBILICAL CORD BLOOD STEM CELLS 77
6. STEM CELL COLLECTION 78
7. CONDITIONING THERAPY 79
8. BLOOD PRODUCT ADMINISTRATION 80
9. PREVENTION AND TREATMENT OF POSTTRANSPLANT INFECTIONS 82
10. GRAFT FAILURE 84
11. GRAFT-VS-HOST DISEASE 85
12. POSTTRANSPLANT PNEUMONIA 88
13. HEPATIC VENO-OCCLUSIVE DISEASE 90
14. THROMBOTIC MICROANGIOPATHY 91
SUGGESTED READING 92
5 Anemias 93
CONTENTS 93
1. INTRODUCTION 93
2. ANEMIAS DUE TO ACUTE BLEEDING 94
3. ANEMIAS DUE TO CHRONIC BLOOD LOSS 94
4. IRON DEFICIENCY ANEMIA 97
4.1. Pathophysiology 97
4.2. Clinical Signs and Diagnosis 98
4.3. Treatment 99
5. ANEMIAS OF CHRONIC DISEASES AND OTHER TYPES OF ANEMIAS 100
5.1. Anemias of Chronic Diseases 100
5.2. Anemias Due to Malnutrition 101
5.3. Anemias Due to Liver Diseases 101
5.4. Anemia of Pregnancy 101
5.5. Anemia of Renal Failure 101
5.6. Anemia of Endocrine Disorders 102
5.7. Thalassemia Minor 102
5.8. Sideroblastic Anemia 102
5.9. Lead Poisoning 103
5.10. Pure Red Cell Aplasia 103
6. MEGALOBLASTIC ANEMIAS 104
6.1. Physiology of Vitamin B12 104
6.2. Physiology of Folate (Pteroyl Glutamic Acid) 105
6.3. Pernicious Anemia 105
6.4. Other Causes of Vitamin B12 Deficiencies 108
6.5. Megaloblastic Anemias Due to Folate Deficiency 108
SUGGESTED READING 109
6 Hemolytic Anemias 110
CONTENTS 110
1. INTRODUCTION 110
2. INHERITED MEMBRANE DEFECTS 111
2.1. Hereditary Spherocytosis 111
2.2. Hereditary Elliptocytosis 112
2.3. Hereditary Pyropoikilocytosis 112
3. INHERITED ENZYME DEFECTS 114
3.1. G6PD Deficiency 114
3.2. Pyruvate Kinase Deficiency 115
3.3. Other Red Cell Enzyme Deficiencies Associated With Hemolytic Anemia 116
4. HEMOGLOBINOPATHIES 116
4.1. Sickle Cell Anemia 116
4.2. Thalassemias 124
4.3. HbC Disease 126
4.4. HbE Syndromes 126
4.5. Methemoglobinemia 126
5. ACQUIRED HEMOLYTIC ANEMIAS 127
5.1. Autoimmune Hemolytic Anemias 127
5.2. Paroxysmal Nocturnal Hemoglobinuria 129
5.3. Hemolytic Disease of the Newborn 130
5.4. Special Forms of Acquired Hemolytic Anemias 132
SUGGESTED READING 135
7 Leukocytosis, Leukopenia, and Other Reactive Changes of Myelopoiesis 136
CONTENTS 136
1. DEFINITIONS AND PATHOPHYSIOLOGY 136
2. DIFFERENTIAL DIAGNOSIS OF LEUKOCYTOSIS ( NEUTROPHILIC LEUKOCYTOSIS) 137
3. DIFFERENTIAL DIAGNOSIS OF LEUKOPENIA ( GRANULOCYTOPENIA) 139
4. DRUG-INDUCED NEUTROPENIA (AGRANULOCYTOSIS) 140
5. CYCLIC NEUTROPENIA 142
6. DIFFERENTIAL DIAGNOSIS OF EOSINOPHILIA 142
7. DIFFERENTIAL DIAGNOSIS OF BASOPHILIA 143
8. DIFFERENTIAL DIAGNOSIS OF MONOCYTOSIS 144
SUGGESTED READING 144
8 The Myeloproliferative Syndromes 145
CONTENTS 145
1. INTRODUCTION 145
2. CHRONIC MYELOGENOUS LEUKEMIA 145
2.1. Basic Biology 146
2.2. Clinical Manifestations 147
2.3. Laboratory Abnormalities 147
2.4. Treatment 148
3. POLYCYTHEMIA VERA 152
3.1. Basic Biology 154
3.2. Clinical Manifestations 154
3.3. Diagnosis 155
3.4. Differential Diagnosis 155
3.5. Treatment 156
4. ESSENTIAL THROMBOCYTHEMIA 157
4.1. Basic Biology 157
4.2. Clinical Manifestations 158
4.3. Diagnosis 158
4.4. Treatment 158
4.5. Prognosis 159
5. IDIOPATHIC MYELOFIBROSIS 159
5.1. Basic Biology 159
5.2. Clinical Manifestations 160
5.3. Diagnosis 160
5.4. Differential Diagnosis 160
5.5. Treatment 160
6. OTHER MYELOPROLIFERATIVE SYNDROMES 161
SUGGESTED READING 162
9 Acute Myelogenous Leukemias 163
CONTENTS 163
1. INTRODUCTION 163
2. ETIOLOGY, BIOLOGY, AND PATHOPHYSIOLOGY OF AML 163
3. CLINICAL MANIFESTATIONS 166
4. DIAGNOSIS AND CLASSIFICATION OF AML 167
4.1. Differential Diagnosis of AML 169
4.2. Laboratory Features of AML and Further Laboratory Investigations 169
5. PROGNOSTIC FACTORS IN AML 171
6. TREATMENT STRATEGIES 174
6.1. Induction Treatment 174
6.2. Complications of Treatment 175
6.3. Consolidation Treatment 175
6.4. Role of Allogeneic Bone Marrow Transplantation 176
6.5. Role of Autologous Transplantation 176
6.6. Treatment of Relapsed or Refractory AML 177
6.7. Treatment of APL 177
6.8. Treatment of Secondary Leukemias 178
6.9. Treatment of AML in Older Patients, Antibody Conjugates 178
6.10. New Treatment Strategies and Outlook 179
SUGGESTED READING 179
10 Acute Lymphoblastic Leukemias 181
CONTENTS 181
1. INTRODUCTION 181
2. MOLECULAR BIOLOGY OF ALL 182
3. CLINICAL MANIFESTATIONS 186
4. DIAGNOSIS AND CLASSIFICATION OF ALL 186
5. PROGNOSTIC FACTORS AND COMPLICATIONS IN ALL 191
6. TREATMENT STRATEGIES 192
6.1. Induction Treatment 192
6.2. Consolidation Treatment 192
6.3. Continuation or Maintenance Treatment 194
6.4. Prophylaxis of Meningeal Leukemia 196
6.5. Supportive Treatment and Prevention of Early Complications 196
6.6. Cure Rates and Late Complications in ALL 197
6.7. Treatment of Relapsed or Refractory ALL and Indications for BMT 198
6.8. Treatment of B-ALL 198
6.9. Treatment of ALL in Older Patients 199
6.10. Use of Monoclonal Antibodies in the Treatment of ALL 199
6.11. Current Treatment Approaches for Ph+ (BCR/ABL+) ALL 199
6.12. Future Perspectives 200
SUGGESTED READING 200
11 Myelodysplastic Syndromes 202
CONTENTS 202
1. DEFINITION 202
2. ETIOLOGY 202
3. PATHOPHYSIOLOGY 203
4. CLINICAL AND LABORATORY MANIFESTATIONS 205
5. PROGNOSIS 207
6. MDS IN CHILDREN AND YOUNG ADULTS 207
7. TREATMENT 208
SUGGESTED READING 212
12 Aplastic Anemias 213
CONTENTS 213
1. DEFINITION 213
2. ETIOLOGY 213
3. PATHOPHYSIOLOGY 215
4. CLINICAL MANIFESTATIONS 216
5. DIAGNOSIS AND CLASSIFICATION 216
6. TREATMENT 219
7. LATE COMPLICATIONS 221
SUGGESTED READING 222
13 Lymphocytosis, Lymphocytopenia, Lymphadenopathy, and Splenomegaly 223
CONTENTS 223
1. INTRODUCTION AND DEFINITIONS 223
2. DIFFERENTIAL DIAGNOSIS OF A LYMPHOCYTOSIS 224
3. DIFFERENTIAL DIAGNOSIS OF LYMPHOCYTOPENIA 224
4. DIFFERENTIAL DIAGNOSIS OF LYMPHADENOPATHY 225
5. DIFFERENTIAL DIAGNOSIS OF SPLENOMEGALY 227
14 Hodgkin’s Lymphoma 230
CONTENTS 230
1. INTRODUCTION 230
2. EPIDEMIOLOGY 231
3. PATHOGENESIS AND ETIOLOGY 231
4. CLINICAL FEATURES 232
5. DIAGNOSIS AND DIFFERENTIAL DIAGNOSIS, STAGING OF HL 232
6. TREATMENT OPTIONS AND RESULTS 6.1. Treatment 236
6.2. Prognosis 239
7. TREATING RELAPSED HL 240
8. LATE EFFECTS OF TREATMENT 240
SUGGESTED READING 241
15 The Non- Hodgkin’s Lymphomas 242
CONTENTS 242
1. INTRODUCTION 242
2. ETIOLOGY OF NHLs 243
3. CLASSIFICATION 244
4. CLINICAL FEATURES AND DIAGNOSTIC STRATEGIES 246
5. DIFFUSE LARGE B-CELL LYMPHOMA 248
5.1. Prognostic Factors in High-Grade NHL 249
5.2. Gene Expression Profiling in Diffuse Large B-Cell Lymphoma 249
5.3. Treatment 250
6. FOLLICULAR LYMPHOMA 253
6.1. Clinical Symptoms 253
6.2. Prognosis 254
6.3. Treatment 255
6.4. Novel Strategies 257
7. MANTLE CELL LYMPHOMA 257
8. CHRONIC LYMPHOCYTIC LEUKEMIA 258
9. LYMPHOPLASMACYTOID/-IC LYMPHOMA/ IMMUNOCYTOMA ( INCLUDING WALDENSTRÖM’S DISEASE) 263
10. BURKITT’S LYMPHOMAS, BURKITT-LIKE LYMPHOMAS, AND LYMPHOBLASTIC LYMPHOMAS 264
11. MYCOSIS FUNGOIDES (CUTANEOUS T-CELL LYMPHOMA) AND SÉZARY SYNDROME 265
12. SPECIAL FORMS OF NHL 266
12.1. Hairy Cell Leukemia 266
12.2. Gastric and MALT Lymphomas 269
12.3. Angioimmunoblastic T-Cell Lymphoma 271
12.4. Anaplastic Large-Cell Lymphoma 271
12.5. Lymphomas in Children 272
12.6. Lymphomas in HIV-Infected Individuals 272
12.7. Cerebral Lymphomas 273
12.8. Splenic Marginal Zone Lymphoma 274
SUGGESTED READING 274
16 Multiple Myeloma and Related Paraproteinemias 284
CONTENTS 284
1. INTRODUCTION 284
2. EPIDEMIOLOG Y OF MM 285
3. PLASMA CELL DYSCRASIAS 285
4. BIOLOGY OF MM 287
5. DIAGNOSIS AND STAGING OF MM 290
6. THERAPY OF MM 297
7. COMPLICATIONS OF MM 302
8. AMYLOIDOSIS 306
SUGGESTED READING 307
17 Congenital and Acquired Immunodeficiencies 308
CONTENTS 308
1. INTRODUCTION 308
2. CONGENITAL IMMUNODEFICIENCIES 309
2.1. Severe Combined Immunodeficiencies 315
2.2. Antibody Deficiencies 316
2.3. B-Cell Defects of Unknown Cause 317
2.4. Cellular Deficiencies 318
2.5. Field Defects That Lead to T-Cell Dysfunction 319
2.6. Combined Deficiencies 320
2.7. Defects in Pathways of T-Cell Death and Regulation 320
2.8. Defects of T-Cell Regulation 321
2.9. Defects of DNA Repair 321
2.10. Congenital Defects of Complement Components 322
3. ACQUIRED OR SECONDARY IMMUNODEFICIENCIES 322
4. HEMATOLOGICAL ASPECTS OF AIDS 323
SUGGESTED READING 326
18 Infections Relevant to Hematology 327
CONTENTS 327
1. INTRODUCTION 327
2. INFECTIOUS MONONUCLEOSIS AND OTHER EPSTEIN- BARR VIRUS SYNDROMES 328
3. CMV INFECTIONS 330
4. PARVOVIRUS B19 INFECTIONS 331
5. PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY 332
6. TOXOPLASMOSIS 333
7. PNEUMOCYSTIS CARINII PNEUMONIAS 334
8. INFECTIONS CAUSED BY HUMAN HERPESVIRUS-6 335
9. INFECTIONS CAUSED BY HUMAN HERPESVIRUS-8 335
9.1. Introduction 335
9.2. Biology of HHV-8 335
9.3. Diagnosis and Epidemiology of HHV-8 Infections 336
9.4. Treatment of HHV-8-Associated Disorders 337
SUGGESTED READING 337
19 Basic Principles of Hemostasis 338
CONTENTS 338
1. NORMAL HEMOSTATIC MECHANISMS 338
2. ENDOTHELIUM AND THE VASCULAR SYSTEM 339
3. THE ROLE OF PLATELETS 339
4. THE ROLE OF BLOOD COAGULATION 342
5. INHIBITORS OF THE PLASMATIC COAGULATION SYSTEM 345
5.1. Antithrombin 345
5.2. Protein C and Protein S 346
6. ROLE OF FIBRINOLYSIS 347
7. CLINICAL EVALUATION OF HEMORRHAGIC DISORDERS 349
8. LABORATORY EVALUATION OF HEMOSTATIC DISORDERS 350
8.1. Screening Tests 351
8.2. Interpretation the Screening Tests of Hemostasis 352
8.3. Specific Assays of Coagulation 354
8.4. Tests of Hypercoagulability and Fibrinolysis 355
SUGGESTED READING 356
20 Bleeding Disorders 357
CONTENTS 357
1. VASCULAR DISORDERS ASSOCIATED WITH BLEEDING 357
1.1. Hereditary Vascular Malformations 357
1.2. Acquired Vascular Disorders 358
2. PLATELET DISORDERS 360
2.1. Quantitative Disorders of Platelets 360
2.2. Investigation of Thrombocytopenia 360
2.3. Thrombocytopenia Due to Decreased Platelet Production 361
2.4. Thrombocytopenia Due to Increased Platelet Destruction 362
2.5. Immune Thrombocytopenia 362
2.6. Idiopathic Thrombocytopenic Purpura 362
2.7. Treatment in Adults 363
2.8. Other Autoimmune Conditions 365
2.9. Drug-Induced Thrombocytopenia 365
2.10. Posttransfusion Purpura 365
2.11. Neonatal Purpura 366
2.12. Nonimmune Thrombocytopenia 366
2.13. Thrombotic Thrombocytopenic Purpura (Moschcowitz’s Disease) and Hemolytic- Uremic Syndrome ( Gasser’s Syndrome) 366
2.14. Cavernous Hemangioma (Kasabach-Meritt Syndrome) 368
2.15. Cardiopulmonary Bypass 368
2.16. Hypersplenism 369
2.17. Thrombocytosis 369
3. QUALITATIVE PLATELET DISORDERS 369
3.1. Bernard-Soulier Syndrome (BSS) 370
3.2. Thrombasthenia (Glanzmann Disease) 370
3.3. Abnormalities of Platelet Secretion 371
3.4. -Granule Deficiency (Gray Platelet Syndrome, -Storage Pool Disease) 371
3.5. Dense Granule Deficiency ( 372
3.6. Acquired Disorders of Platelet Function 372
4. INHERITED DISODERS OF BLOOD COAGULATION 374
4.1. Hemophilias A and B 374
4.2. Von Willebrand Disease 379
4.3. Other Inherited Disorders of Coagulation Factors 381
5. ACQUIRED COAGULATION DISORDERS 382
5.1. Vitamin K Deficiency 382
5.2. Liver Disease 384
5.3. Disseminated Intravascular Coagulation 384
5.4. Acquired Inhibitors 387
5.5. Massive Transfusions 388
REFERENCES 389
SUGGESTED READING 389
21 Thrombophilia, Thromboembolic Disease, and Antithrombotic Therapy 391
CONTENTS 391
1. THROMBOPHILIA (HYPERCOAGULABILITY) 391
1.1. Inherited Hypercoagulable States 392
1.2. Acquired Hypercoagulable States 395
1.3. Management of Thrombophilia 396
2. THROMBOEMBOLIC DISEASE 396
2.1. Venous Thrombosis 397
2.2. Pulmonary Embolism 399
2.3. Arterial Thrombosis 399
3. ANTITHROMBOTIC THERAPY 401
3.1. Unfractionated Heparin 402
3.2. Low-Molecular-Weight Heparins 402
3.3. Complications of Heparin Therapy 403
3.4. Oral Anticoagulants 404
3.5. Complications and Interactions 404
3.6. Direct Thrombin Inhibitors (Hirudin) 406
3.7. New Antithrombotic Drugs 406
3.8. Fibrinolytic Therapy 407
3.9. Antiplatelet Drugs 409
REFERENCES 409
SUGGESTED READING 409
22 Transfusion Medicine and Immunohematology 411
CONTENTS 411
1. INTRODUCTION 411
2. RED CELL SEROLOGY 412
2.1. The ABO, Hh, and Sese Systems 412
2.2. The Rhesus System 413
2.3. Other Red Cell Systems 415
2.4. Diagnostic Methods in Blood Group Serology 416
3. LEUKOCYTE ANTIGENS 416
4. BLOOD PRODUCTS AND INDICATIONS FOR BLOOD TRANSFUSION 421
4.1. Whole Blood 421
4.2. Red Blood Cells 421
4.3. Platelets 422
4.4. Granulocytes 423
4.5. Fresh-Frozen Plasma 424
4.6. Cryoprecipitated Antihemophilic Factor 424
4.7. Immunoglobulins 424
5. ADVERSE REACTIONS TO BLOOD TRANSFUSION 425
5.1. Acute Hemolytic Transfusion Reactions 425
5.2. Delayed Hemolytic Transfusion Reaction 427
5.3. Febrile Nonhemolytic Transfusion Reactions 428
5.4. Allergic Reactions 428
6. DISEASES TRANSMITTED BY BLOOD TRANSFUSION 429
6.1. Bacterial Infections Transmitted by Blood Transfusion 430
6.2. Viral Diseases Transmitted by Blood Transfusion 431
6.3. Parasites Transmitted by Blood Transfusion 438
7. OTHER ADVERSE EFFECTS OF BLOOD TRANSFUSION 439
7.1. Iron Overload 439
7.2. Transfusion-Associated GVHD 439
7.3. Transfusion-Related Acute Lung Injury 440
8. AUTOLOGOUS BLOOD TRANSFUSION 440
SUGGESTED READING 441
23 Storage Disorders in Hematology 443
CONTENTS 443
1. GAUCHER DISEASE 443
2. HEREDITARY HEMOCHROMATOSIS 445
3. SECONDARY IRON OVERLOAD 447
SUGGESTED READING 448
Glossary of Cytostatic Drugs and Targeted Therapies 450
Laboratory Values 470
Program Requirements for Residency Education in Hematology 472
RECOMMENDATIONS OF THE ACCREDITATION COUNCIL FOR GRADUATE MEDICAL EDUCATION ( ACGME) 472
RECOMMENDATIONS FOR TRAINING BY ASH AND ASCO 473
Databases in Hematology 474
I. TEXTBOOKS OF HEMATOLOGY AND RELATED DISCIPLINES A. MAJOR TEXTBOOKS (> 1000 PAGES)
II) PERIODICALS SPECIALIZING IN HEMATOLOGY OR PUBLISHING MAJOR HEMATOLOGIC ARTICLES ( IMPACT FACTOR GIVEN FOR 2004) 477
III. ELECTRONIC DATABASES AND SOURCES OF INFORMATION 477
IV. SPECIALIZED WEBSITES AND ORGANIZATIONS 478
V. PROFESSIONAL ASSOCIATIONS OF HEMATOLOGISTS AND RELATED SPECIALISTS OR SCIENTISTS 480
VI. PATIENT-ORIENTED DATABASES AND SOURCES OF INFORMATION 481
Index 482
| Erscheint lt. Verlag | 6.11.2007 |
|---|---|
| Reihe/Serie | Contemporary Hematology |
| Zusatzinfo | XIV, 498 p. 62 illus., 18 illus. in color. |
| Verlagsort | Totowa |
| Sprache | englisch |
| Themenwelt | Medizinische Fachgebiete ► Innere Medizin ► Hämatologie |
| Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie | |
| Schlagworte | anemia • Blood • Bone marrow • Chemotherapy • cytokines • Hematology • immunotherapy • leukemia • Lymphoma • Molecular Biology • pharmacology • Stem Cells • Transfusion Medicine • Transplantation |
| ISBN-10 | 1-59745-149-5 / 1597451495 |
| ISBN-13 | 978-1-59745-149-9 / 9781597451499 |
| Haben Sie eine Frage zum Produkt? |
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