Peptide Science - Present and Future (eBook)

Contents 5
Preface 35
First International Peptide Symposium 37
Acknowledgements 39
Abbreviations 41
From big molecules to smaller ones 47
Directions for solving the remaining problems in the synthesis of large peptides 52
Theoretical analysis of ßaßaß-type packing motifs formed by alternate intramolecular arrangements of three a-helices and three ß-strands 141
Characterization of sulfhydryl compounds attached to the cysteinyl residue of proteins or peptides by on-line post-column derivatization 198
Regioselective hydrolytic cleavage of N-terminal myristoyl-peptide 200
Determination of the binding-site structure of the atrial natriuretic peptide receptor by stepwise-affinity alkylation 209
A novel type of rat brain d opioid receptors differenciated by cyclopropylphenylalanine-containing enkephalin analog 253
Conformational analysis of peptide fragments corresponding to domains of potassium ion- channel proteins 301
Formation of native disulphide bonds in endothelin-1: evidence for the involvement of a highly specific salt-bridge between the pro-sequence of endothelin-1 and mature sequence 312
Sequence, conformation, and function of peptides, retro peptides and sense and antisense gene products 359
Topological isomers of human uroguanylin: structure determination by nuclear magnetic resonance 370
Circular dichroism and fluorescence study of the interaction of synthetic J protein from bacteriophage fK with DNA 419
Unusual collagen assembly induced by acidic biopolymers in vitro 422
Nociceptin, a novel neuropeptide with multiple functions 434
An anti-HIV peptide T22 is confirmed to be a selective CXCR4/ fusin inhibitor by comparative inhibition study of a chemokine SDF- 1, synthesized by regioselective disulfide bond formation 444
Effect of carnosine and its natural derivatives on apoptosis of neurons induced by excitotoxic compounds 459
Purification of peptide fractions with anticomplementary activity from red ginseng (Panax ginseng, C.A. Meyer) 467
Chemical and biological characterization of neuropeptides in the sinus glands of the kuruma prawn, Penaeus japonicus 499
Macrotorials: synthesis and characterization of model compounds related to PTH (1 – 34) 518
Combined solid-phase and solution approach to protein synthesis 536
Enzymatic peptide synthesis using activated esters as acyl donors in organic media 560
Studies of racemization in peptide synthesis for a phosphoryloxy-benzotriazin-one coupling reagent (DEPBT) 576
Diastereoselective synthesis of glycosyl- a-aminoacids and glycopeptide derivatives 641
Influence of glycation on cis/trans isomerization and tautomerization in novel morphiceptin-related Amadori compounds 646
Design of novel, nonpeptide oxytocin receptor antagonists 664
The substrate specificity of microbial carboxyl proteinases 703
Allophenylnorstatine containing HIV-1 protease inhibitors: design, synthesis and structure – activity relationships for selected P2 and P2' ligands 706
Cell specific gene transfer using galactose-modified peptide 755
Synthesis and biological activities of hPTH(1–34) analogues: modification of the middle part and C-terminal alkylamides 757
Hybridization properties of nucleic acid analogs bearing peptide backbone 791
Physiological role of the delta sleep-inducing peptide (DSIP) 803
Effect of nitroprusside on amyloid ß-peptide induced inhibition of MTT reduction in pheochromocytoma PC12h and C1300 neuroblastoma cells 823
Molecular design of T cell-costimulatory peptides for vaccine development 847
The identification of dominant epitopes of h-FKBP-12 recognized by monoclonal antibodies, 3F4 and 2C1, against h-FK-506 binding protein 12(h-FKBP-12) 849
Conformational and binding studies of the peptide isolated from phage display library by anti- mouse CTLA-4 monoclonal antibody 856
Formation of DNA-anti-DNA antibody immune complex on collagen matrix 859
Natural IgM antibodies against human endogenous retroviruses HERV-H demonstrated by means of synthetic peptides 862
Evaluation of region-specific antibodies for rat and human Chromogranin A with use of synthetic peptide 864
Design of synthetic antigen containing nonimmunogenic T cell epitope core and simple nonnative flanking regions 866
Immune response to newly exposed regions of Band 3 protein of the red blood cell membrane during malaria infections 869
Peptide-induced antibodies as a tool to link genomes and proteomes 871
Porphyrin-peptide conjugates with stabilized helices and sheets 874
Molecular recognition of cyclic HIV protease inhibitors: highly orally-bioavailable DMP851 877
Index 879